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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism



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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 ISO RGD PMID:16476568 RGD:2317620 NCBI chr18:43,164,504...43,195,038
Ensembl chr18:46,512,374...46,542,737
JBrowse link
G ACACA acetyl-CoA carboxylase alpha involved_in ISO (MGI:4840155|PMID:20952656) UniProt PMID:20952656 MGI:4840155 NCBI chr17:19,670,114...19,998,903
Ensembl chr17:19,969,205...20,297,651
JBrowse link
G ACACB acetyl-CoA carboxylase beta involved_in ISO (PMID:20952656) UniProt PMID:20952656 NCBI chr12:106,692,668...106,845,490
Ensembl chr12:110,086,374...110,239,847
JBrowse link
G ACLY ATP citrate lyase ISO RGD PMID:18062843 RGD:2317315 NCBI chr17:15,385,335...15,447,269
Ensembl chr17:15,615,994...15,664,800
JBrowse link
G ACOT12 acyl-CoA thioesterase 12 acts_upstream_of_or_within ISO (MGI:2450440|PMID:12545200) MGI PMID:12545200 MGI:2450440 NCBI chr 5:33,885,302...33,950,075
Ensembl chr 5:34,196,504...34,260,254
JBrowse link
G CS citrate synthase ISO RGD PMID:818082 PMID:938457 PMID:5820645 RGD:2306824 RGD:2306825 RGD:2306828 NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854
JBrowse link
G FASN fatty acid synthase ISO RGD PMID:18062843 RGD:2317315 NCBI chr17:76,483,108...76,503,148
Ensembl chr17:82,187,516...82,205,647
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO (PMID:23751782) UniProt PMID:23751782 NCBI chr 1:82,778,489...82,798,987
Ensembl chr 1:117,775,770...117,796,679
JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chr11:103,008,564...103,034,697
Ensembl chr11:106,483,563...106,509,787
JBrowse link
G ACLY ATP citrate lyase involved_in ISO (PMID:1371749) BHF-UCL PMID:1371749 NCBI chr17:15,385,335...15,447,269
Ensembl chr17:15,615,994...15,664,800
JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 involved_in
acts_upstream_of_or_within
ISO (PMID:16788062)
(MGI:2151932|PMID:11150295)
UniProt
MGI
PMID:11150295 PMID:16788062 MGI:2151932 NCBI chr20:24,946,629...25,001,311
Ensembl chr20:25,293,511...25,349,017
JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 acts_upstream_of_or_within ISO (MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:2151932 NCBI chr20:31,205,104...31,256,263
Ensembl chr20:32,329,721...32,380,526
JBrowse link
G DIP2A disco interacting protein 2 homolog A involved_in ISO (MGI:6478983|PMID:30672040) UniProt PMID:30672040 MGI:6478983 NCBI chr21:32,921,019...33,034,988
Ensembl chr21:46,060,713...46,168,885
JBrowse link
G MLYCD malonyl-CoA decarboxylase involved_in ISO (PMID:10417274), (PMID:10455107), (PMID:9869665) RGD
UniProt
PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 RGD:1600790 NCBI chr16:64,520,860...64,537,955
Ensembl chr16:83,912,793...83,929,162
JBrowse link
G PPCS phosphopantothenoylcysteine synthetase involved_in ISO (PMID:29754768) UniProt PMID:29754768 NCBI chr 1:41,756,403...41,773,430
Ensembl chr 1:43,136,720...43,140,620
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLAT dihydrolipoamide S-acetyltransferase ISO RGD PMID:7487891 RGD:1599112 NCBI chr11:106,910,857...106,950,851
Ensembl chr11:110,756,001...110,792,795
JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chr 7:99,872,020...99,901,884
Ensembl chr 7:112,593,934...112,623,629
JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in ISO (PMID:19081061) RGD
UniProt
PMID:7487891 PMID:19081061 RGD:1599112 NCBI chr  X:11,967,944...11,985,837
Ensembl chr  X:19,330,508...19,348,443
JBrowse link
G PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 ISO RGD PMID:7487891 RGD:1599112 NCBI chr 4:88,213,492...88,216,451
Ensembl chr 4:98,883,109...98,884,853
JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta involved_in ISO (PMID:19081061) RGD
UniProt
PMID:7487891 PMID:19081061 RGD:1599112 NCBI chr 3:58,359,753...58,366,094
Ensembl chr 3:59,776,618...59,782,411
JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chr11:103,008,564...103,034,697
Ensembl chr11:106,483,563...106,509,787
JBrowse link
G NUDT7 nudix hydrolase 7 acts_upstream_of_or_within
involved_in
ISO (MGI:2137102|PMID:11415433)
(MGI:6157214|PMID:29378847), (MGI:6450264|PMID:18799520)
MGI
UniProt
PMID:11415433 PMID:18799520 PMID:29378847 MGI:2137102 MGI:6157214 MGI:6450264 NCBI chr16:58,312,917...58,333,256
Ensembl chr16:77,747,863...77,801,651
JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MVD mevalonate diphosphate decarboxylase ISO RGD PMID:197206 RGD:2316852 NCBI chr16:69,365,070...69,376,149
Ensembl chr16:89,025,572...89,036,964
JBrowse link
G MVK mevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chr12:107,150,477...107,173,978
Ensembl chr12:110,544,991...110,568,524
JBrowse link
G PMVK phosphomevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chr 1:130,273,246...130,286,614
Ensembl chr 1:133,882,840...133,894,818
JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIPOX pipecolic acid and sarcosine oxidase involved_in ISO (PMID:10642506) UniProt PMID:10642506 NCBI chr17:27,717,083...27,820,776
Ensembl chr17:28,225,831...28,240,210
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPC1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:5428352 NCBI chr 6:164,331,604...164,349,747 JBrowse link
G MPC2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558)
(MGI:5576400|PMID:24910426)
MGI PMID:22628558 PMID:24910426 MGI:5428352 MGI:5576400 NCBI chr 1:143,406,611...143,424,508
Ensembl chr 1:147,132,213...147,151,648
JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within ISO (MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:3817854 NCBI chr  X:11,967,944...11,985,837
Ensembl chr  X:19,330,508...19,348,443
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDK1 pyruvate dehydrogenase kinase 1 involved_in ISO (MGI:5487511|PMID:22195962) UniProt PMID:22195962 MGI:5487511 NCBI chr2B:59,841,840...59,958,504
Ensembl chr2B:177,297,840...177,341,113
JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in ISO (MGI:5428826|PMID:22360721) UniProt PMID:22360721 MGI:5428826 NCBI chr17:44,185,463...44,202,221
Ensembl chr17:49,060,030...49,076,115
JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) UniProt PMID:22865452 NCBI chr  X:17,062,278...17,147,489
Ensembl chr  X:24,430,028...24,504,730
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in ISO (PMID:21852536)
(MGI:3692363|PMID:16606348)
UniProt PMID:16606348 PMID:21852536 MGI:3692363 NCBI chr 7:87,540,600...87,553,673
Ensembl chr 7:101,128,060...101,141,157
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYNU kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chr2B:16,792,401...16,947,766
Ensembl chr2B:146,975,995...147,132,634
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase ISO RGD PMID:7236232 RGD:2303721 NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12659
    metabolic process 7935
      organic substance metabolic process 7648
        thioester metabolic process 67
          acyl-CoA metabolic process 67
            acetyl-CoA metabolic process 32
              L-lysine catabolic process to acetyl-CoA + 1
              L-threonine catabolic process to acetyl-CoA 0
              acetyl-CoA biosynthetic process + 18
              acetyl-CoA catabolic process + 2
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
              tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 12659
    cellular process 11795
      cellular metabolic process 7257
        heterocycle metabolic process 3835
          nucleobase-containing compound metabolic process 3724
            nucleobase-containing small molecule metabolic process 387
              nucleoside phosphate metabolic process 345
                nucleotide metabolic process 339
                  ribonucleotide metabolic process 285
                    purine ribonucleotide metabolic process 270
                      acyl-CoA metabolic process 67
                        acetyl-CoA metabolic process 32
                          L-lysine catabolic process to acetyl-CoA + 1
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 18
                          acetyl-CoA catabolic process + 2
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root