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ONTOLOGY REPORT - ANNOTATIONS


Term:fructose 2,6-bisphosphate metabolic process
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Accession:GO:0006003 term browser browse the term
Definition:The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
Synonyms:exact_synonym: fructose 2,6-bisphosphate metabolism


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fructose 2,6-bisphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gck glucokinase IDA Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate RGD PMID:17553851 RGD:2301905 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 involved_in TAS
ISO
IBA
ISS
IEA
(PMID:2837207)
PMID:21873635
GO_REF:0000024
GO_REF:0000002
RGD
UniProt
InterPro
PMID:2837207, PMID:2549541, PMID:21873635 GO_REF:0000002 GO_REF:0000024, RGD:729562, RGD:13792537 NCBI chr  X:23,092,143...23,145,923
Ensembl chr  X:23,092,159...23,144,324
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 involved_in TAS
IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro PMID:1652483, PMID:21873635 GO_REF:0000002, RGD:1299004, RGD:13792537 NCBI chr13:47,413,453...47,440,682
Ensembl chr13:47,413,458...47,440,682
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 involved_in IDA
IEA
IBA
Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate
GO_REF:0000002
PMID:21873635
InterPro PMID:17553851, PMID:21873635 GO_REF:0000002, RGD:2301905, RGD:13792537 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 involved_in IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:19015259)
PMID:21873635
(MGI:4867601|PMID:20935145)
RGD PMID:19015259 PMID:20935145, PMID:21873635 MGI:4867601, RGD:13792537 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        organophosphate metabolic process 936
          fructose 2,6-bisphosphate metabolic process 6
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        phosphorus metabolic process 2829
          phosphate-containing compound metabolic process 2807
            fructose 2,6-bisphosphate metabolic process 6
paths to the root