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ONTOLOGY REPORT - ANNOTATIONS


Term:fructose 2,6-bisphosphate metabolic process
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Accession:GO:0006003 term browser browse the term
Definition:The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
Synonyms:exact_synonym: fructose 2,6-bisphosphate metabolism



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fructose 2,6-bisphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gck glucokinase IDA Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate RGD PMID:17553851 RGD:2301905 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 involved_in TAS
ISO
IBA
ISS
IEA
(PMID:2837207)
PMID:21873635
GO_REF:0000024
GO_REF:0000002
RGD
UniProt
InterPro
PMID:2837207 PMID:2549541 PMID:21873635 GO_REF:0000002 GO_REF:0000024, RGD:729562, RGD:13792537 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 involved_in TAS
IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro
RGD
PMID:1652483 PMID:21873635 GO_REF:0000002, RGD:1299004, RGD:13792537 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 involved_in IDA
IEA
IBA
Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate
GO_REF:0000002
PMID:21873635
InterPro
RGD
PMID:17553851 PMID:21873635 GO_REF:0000002, RGD:2301905, RGD:13792537 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 involved_in IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in
acts_upstream_of_or_within
ISO (PMID:19015259)
(MGI:4867601|PMID:20935145)
RGD PMID:19015259 PMID:20935145 MGI:4867601 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      organic substance metabolic process 11020
        organophosphate metabolic process 959
          fructose 2,6-bisphosphate metabolic process 6
Path 2
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      cellular metabolic process 9697
        phosphorus metabolic process 2830
          phosphate-containing compound metabolic process 2810
            fructose 2,6-bisphosphate metabolic process 6
paths to the root