Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:fructose 2,6-bisphosphate metabolic process
go back to main search page
Accession:GO:0006003 term browser browse the term
Definition:The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
Synonyms:exact_synonym: fructose 2,6-bisphosphate metabolism


show annotations for term's descendants           Sort by:
fructose 2,6-bisphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gck glucokinase IDA Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate RGD PMID:17553851 RGD:2301905 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 involved_in TAS
IEA
ISS
IBA
ISO		 GO_REF:0000002
GO_REF:0000024
PMID:21873635
(PMID:2837207)		 InterPro
UniProt
RGD		 PMID:2837207 PMID:2549541 PMID:21873635 GO_REF:0000002 GO_REF:0000024, RGD:729562, RGD:13792537 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 involved_in TAS
IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro
RGD		 PMID:1652483 PMID:21873635 GO_REF:0000002, RGD:1299004, RGD:13792537 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 involved_in IDA
IBA
IEA		 Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate
PMID:21873635
GO_REF:0000002		 InterPro
RGD		 PMID:17553851 PMID:21873635 GO_REF:0000002, RGD:2301905, RGD:13792537 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 involved_in IBA
IEA		 PMID:21873635
GO_REF:0000002		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19572
    metabolic process 11554
      organic substance metabolic process 10906
        organophosphate metabolic process 903
          fructose 2,6-bisphosphate metabolic process 6
Path 2
Term Annotations click to browse term
  biological_process 19572
    metabolic process 11554
      cellular metabolic process 10141
        phosphorus metabolic process 2069
          phosphate-containing compound metabolic process 2041
            fructose 2,6-bisphosphate metabolic process 6
paths to the root