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ONTOLOGY REPORT - ANNOTATIONS

Term:fructose 2,6-bisphosphate metabolic process
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Accession:GO:0006003 term browser browse the term
Definition:The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
Synonyms:exact_synonym: fructose 2,6-bisphosphate metabolism


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fructose 2,6-bisphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gck glucokinase IDA Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate RGD PMID:17553851 RGD:2301905 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 involved_in TAS
IBA
ISO
ISS
IEA		 GO_REF:0000033
(PMID:2837207)
GO_REF:0000024
GO_REF:0000002		 GO_Central
RGD
UniProt
InterPro		 PMID:2837207 PMID:2549541 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:729562 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 involved_in TAS
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:1652483 GO_REF:0000002 GO_REF:0000033, RGD:1299004 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 involved_in IDA
IEA
IBA		 Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate
GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central
RGD		 PMID:17553851 GO_REF:0000002 GO_REF:0000033, RGD:2301905 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO (PMID:20935145) RGD PMID:20935145 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
Ensembl chr 6:159,927,139...159,946,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        carbohydrate derivative metabolic process 1040
          fructose 2,6-bisphosphate metabolic process 6
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        phosphorus metabolic process 2406
          phosphate-containing compound metabolic process 2403
            fructose 2,6-bisphosphate metabolic process 6
paths to the root