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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex



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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cish cytokine inducible SH2-containing protein part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G P3r3urf PIK3R3 upstream open reading frame part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:129,656,654...129,673,140
Ensembl chr 5:129,656,833...129,672,848
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IDA
ISO
IBA
PR:Q64143 (MGI:84168|PMID:7542745)
PMID:21873635
RGD PMID:7542745 PMID:12882977 PMID:21873635 MGI:84168, RGD:4144086, RGD:13792537 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12882977 PMID:21873635 RGD:4144086, RGD:13792537 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12882977 PMID:21873635 RGD:4144086, RGD:13792537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 part_of TAS
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:8621382 PMID:21873635 PMID:20236230 PMID:12882977 RGD:68289, RGD:13792537, RGD:4107732, RGD:4144086 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 part_of IBA
ISO
PMID:21873635
PR:P42337 (MGI:84168|PMID:7542745)
RGD PMID:7542745 PMID:21873635 MGI:84168, RGD:13792537 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12882977 PMID:21873635 RGD:4144086, RGD:13792537 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243
JBrowse link
G Sla2 Src-like-adaptor 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:145,367,070...145,383,586
Ensembl chr 3:145,368,598...145,382,480
JBrowse link
G Socs1 suppressor of cytokine signaling 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs2 suppressor of cytokine signaling 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Socs3 suppressor of cytokine signaling 3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Socs4 suppressor of cytokine signaling 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494
JBrowse link
G Socs5 suppressor of cytokine signaling 5 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
G Socs6 suppressor of cytokine signaling 6 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219
JBrowse link
G Socs7 suppressor of cytokine signaling 7 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830
JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vac14 VAC14 component of PIKFYVE complex part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:38,590,569...38,691,911
Ensembl chr19:38,590,569...38,691,909
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IBA
ISO
PMID:21873635
(PMID:22402981)
RGD PMID:22402981 PMID:21873635 RGD:13792537 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 part_of ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma part_of IBA
ISO
PMID:21873635
(PMID:12507995)
RGD PMID:12507995 PMID:21873635 RGD:13792537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of ISO
IEA
(PMID:12507995)
GO_REF:0000002
RGD
InterPro
PMID:12507995 GO_REF:0000002 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of ISO (MGI:3574247|PMID:15797027) RGD PMID:15797027 MGI:3574247 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 part_of IBA
ISO
ISS
PMID:21873635
(MGI:5619439|PMID:23332761)
GO_REF:0000024
RGD
UniProt
PMID:23332761 PMID:21873635 GO_REF:0000024 MGI:5619439, RGD:13792537 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Becn1 beclin 1 part_of ISS
ISO
GO_REF:0000024
(MGI:5619439|PMID:23332761)
UniProt
RGD
PMID:23332761 GO_REF:0000024 MGI:5619439 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 colocalizes_with
part_of
ISO
IEA
(PMID:24785657)
(MGI:5634877|PMID:24849286)
GO_REF:0000107
RGD
Ensembl
PMID:24785657 PMID:24849286 GO_REF:0000107 MGI:5634877 NCBI chr20:21,308,606...21,326,878
Ensembl chr20:21,308,576...21,326,818
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of ISS
ISO
GO_REF:0000024
(MGI:5619439|PMID:23332761)
UniProt
RGD
PMID:23332761 GO_REF:0000024 MGI:5619439 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of ISS
ISO
GO_REF:0000024
(MGI:5619439|PMID:23332761)
UniProt
RGD
PMID:23332761 GO_REF:0000024 MGI:5619439 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Becn2 beclin 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:87,843,528...87,892,343
Ensembl chr13:87,844,531...87,845,787
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Becn2 beclin 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:87,843,528...87,892,343
Ensembl chr13:87,844,531...87,845,787
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19896
    cellular anatomical entity 19599
      extrinsic component of membrane 336
        phosphatidylinositol 3-kinase complex 30
          phosphatidylinositol 3-kinase complex, class I + 6
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 19896
    protein-containing complex 5946
      catalytic complex 1450
        transferase complex 792
          transferase complex, transferring phosphorus-containing groups 256
            phosphatidylinositol 3-kinase complex 30
              phosphatidylinositol 3-kinase complex, class I + 6
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root