ONTOLOGY REPORT - ANNOTATIONS
Term: actin filament
Accession: GO:0005884
browse the term
Definition: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
Synonyms: exact_synonym: microfilament
xref: FMA:63850; NIF_Subcellular:sao1588493326; Wikipedia:Actin
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ABI2
abl interactor 2
located_in
ISO
(PMID:15572692)
UniProt
PMID:15572692
NCBI chr37:12,162,815...12,278,505
Ensembl chr37:12,162,392...12,282,395
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ACKR2
atypical chemokine receptor 2
located_in
ISO
(PMID:23633677)
UniProt
PMID:23633677
NCBI chr23:11,904,020...11,962,291
Ensembl chr23:11,960,981...11,962,135
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ACTA1
actin alpha 1, skeletal muscle
located_in
ISO
(PMID:12849983)
UniProt
PMID:12849983
NCBI chr 4:9,811,726...9,814,533
Ensembl chr 4:9,811,801...9,814,530
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ACTB
actin beta
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 6:12,421,006...12,424,449
Ensembl chr 6:12,418,932...12,462,845
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ACTC1
actin alpha cardiac muscle 1
located_in
ISO
(PMID:16611632), (PMID:19799913)
UniProt
PMID:16611632 PMID:19799913
NCBI chr30:2,514,825...2,519,398
Ensembl chr30:2,514,824...2,519,382
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ACTG1
actin gamma 1
located_in
ISO
(PMID:28493397)
UniProt
PMID:28493397
NCBI chr 9:635,978...638,328
Ensembl chr 9:635,978...638,328
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ACTN1
actinin alpha 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:42,714,806...42,808,318
Ensembl chr 8:42,712,142...42,808,323
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ACTR3
actin related protein 3
located_in
ISO
RGD
PMID:10209028
RGD:2306208
NCBI chr19:35,097,968...35,133,330
Ensembl chr19:35,098,639...35,169,724
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AFAP1
actin filament associated protein 1
ISO
RGD
PMID:12114187
RGD:625602
NCBI chr 3:59,686,887...59,828,924
Ensembl chr 3:59,689,014...59,829,041
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AIF1
allograft inflammatory factor 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:1,104,350...1,106,179
Ensembl chr12:1,104,394...1,106,177
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AIF1L
allograft inflammatory factor 1 like
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:52,944,925...52,966,953
Ensembl chr 9:52,947,570...52,966,894
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AKAP13
A-kinase anchoring protein 13
located_in
ISO
(MGI:5308772|PMID:20139090)
UniProt
PMID:20139090
MGI:5308772
NCBI chr 3:49,076,313...49,310,564
Ensembl chr 3:49,076,642...49,308,221
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AMOT
angiomotin
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:85,742,610...85,807,557
Ensembl chr X:85,745,207...85,807,353
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ANXA1
annexin A1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
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APC2
APC regulator of WNT signaling pathway 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:57,380,472...57,395,249
Ensembl chr20:57,380,460...57,395,226
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AVIL
advillin
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:1,855,598...1,875,156
Ensembl chr10:1,856,162...1,872,303
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CALD1
caldesmon 1
ISO
RGD
PMID:3384851
RGD:2303065
NCBI chr16:13,087,419...13,279,648
Ensembl chr16:13,084,109...13,279,384
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CD2AP
CD2 associated protein
located_in is_active_in
IEA ISO
(PMID:17606992)
Ensembl MGI
PMID:17606992
GO_REF:0000107
NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011
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COBL
cordon-bleu WH2 repeat protein
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:2,206,957...2,386,333
Ensembl chr18:2,208,260...2,459,206
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CORO1A
coronin 1A
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818
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CORO1B
coronin 1B
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:50,027,274...50,031,601
Ensembl chr18:50,027,275...50,050,907
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CTTN
cortactin
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:47,932,367...47,960,732
Ensembl chr18:47,916,632...47,960,674
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DAPK3
death associated protein kinase 3
ISO
RGD
PMID:10602480
RGD:8554171
NCBI chr20:55,590,199...55,603,883
Ensembl chr20:55,590,223...55,602,682
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DBN1
drebrin 1
located_in
ISO
RGD
PMID:10234022
RGD:10395287
NCBI chr 4:35,899,969...35,913,015
Ensembl chr 4:35,889,392...35,912,507
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DLC1
DLC1 Rho GTPase activating protein
located_in
ISO
RGD
PMID:15506980
RGD:1624304
NCBI chr16:36,531,754...36,943,033
Ensembl chr16:36,531,754...36,943,033
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DMTN
dematin actin binding protein
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr25:35,163,867...35,188,761
Ensembl chr25:35,165,876...35,176,754
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DNAJA3
DnaJ heat shock protein family (Hsp40) member A3
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:36,921,941...36,967,718
Ensembl chr 6:36,917,858...36,967,689
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DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
located_in
ISO
(PMID:24327345)
ARUK-UCL
PMID:24327345
NCBI chr31:32,564,970...32,655,232
Ensembl chr31:32,511,502...32,652,572
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EZR
ezrin
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036
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FLNA
filamin A
located_in
ISO
RGD
PMID:15661894 PMID:22872576
RGD:2312435 RGD:7207404
NCBI chr X:122,058,303...122,083,467
Ensembl chr X:122,061,455...122,083,203
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FMN1
formin 1
located_in
IEA
InterPro
GO_REF:0000002
NCBI chr30:1,782,726...2,215,449
Ensembl chr30:1,815,512...2,184,909
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FMN2
formin 2
located_in
IEA
InterPro
GO_REF:0000002
NCBI chr 7:31,657,371...32,024,777
Ensembl chr 7:31,697,245...32,023,472
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FYN
FYN proto-oncogene, Src family tyrosine kinase
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541
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GAS2L1
growth arrest specific 2 like 1
located_in
ISO
(PMID:24706950)
UniProt
PMID:24706950
NCBI chr26:22,615,531...22,620,605
Ensembl chr26:22,615,319...22,621,311
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GAS2L2
growth arrest specific 2 like 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:37,917,863...37,926,149
Ensembl chr 9:37,918,269...37,927,083
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GAS7
growth arrest specific 7
located_in
ISO
(PMID:11795944)
MGI
PMID:11795944
NCBI chr 5:34,334,477...34,457,189
Ensembl chr 5:34,339,098...34,457,164
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GCK
glucokinase
located_in
ISO
in primary rat hepatocytes and transfected COS-7 cells
RGD
PMID:9109397
RGD:2301953
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GDPD2
glycerophosphodiester phosphodiesterase domain containing 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:54,865,674...54,875,536
Ensembl chr X:54,865,818...54,875,530
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GJB6
gap junction protein beta 6
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr25:17,912,036...17,922,310
Ensembl chr25:17,911,262...17,921,605
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GNG12
G protein subunit gamma 12
located_in
ISO
RGD
PMID:9492299
RGD:2314449
NCBI chr 6:77,316,649...77,378,356
Ensembl chr 6:77,338,685...77,374,937
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HCK
HCK proto-oncogene, Src family tyrosine kinase
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr24:21,473,424...21,513,673
Ensembl chr24:21,473,305...21,513,564
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INPP5D
inositol polyphosphate-5-phosphatase D
ISO
RGD
PMID:15661894
RGD:2312435
NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200
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KEAP1
kelch like ECH associated protein 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:50,651,070...50,661,178
Ensembl chr20:50,650,711...50,658,496
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LCP1
lymphocyte cytosolic protein 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:4,955,453...5,059,654
Ensembl chr22:4,992,347...5,059,636
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LMOD1
leiomodin 1
located_in
ISO
PMID:10520227
UniProt
PMID:10520227
RGD:11344950
NCBI chr 7:1,025,022...1,059,254
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LMOD2
leiomodin 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:11,916,842...11,924,616
Ensembl chr14:11,917,878...11,924,438
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MARK2
microtubule affinity regulating kinase 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:53,101,635...53,125,636
Ensembl chr18:53,101,624...53,151,561
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MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
located_in is_active_in
IEA ISO
(PMID:33393173)
Ensembl UniProt
PMID:33393173
GO_REF:0000107
NCBI chr12:66,350,459...66,358,391
Ensembl chr12:66,350,427...66,360,615
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MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
is_active_in
ISO
(PMID:29343822)
UniProt
PMID:29343822
NCBI chr21:35,153,467...35,290,062
Ensembl chr21:35,154,422...35,373,233
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MISP
mitotic spindle positioning
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:57,839,423...57,847,013
Ensembl chr20:57,838,731...57,843,219
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MYH9
myosin heavy chain 9
ISO
RGD
PMID:21598299
RGD:12798522
NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953
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MYO1B
myosin IB
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr37:1,748,287...1,921,360
Ensembl chr37:1,747,974...1,920,349
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MYO5A
myosin VA
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr30:17,990,521...18,122,160
Ensembl chr30:17,888,419...18,213,061
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MYO6
myosin VI
located_in
ISO
(PMID:12857860)
UniProt
PMID:12857860
NCBI chr12:37,359,200...37,502,342
Ensembl chr12:37,413,570...37,500,724
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MYO9B
myosin IXB
located_in
ISO IEA
RGD Ensembl
PMID:9348541
GO_REF:0000107 RGD:1581711
NCBI chr20:45,512,286...45,582,619
Ensembl chr20:45,512,276...45,582,619
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PAK1
p21 (RAC1) activated kinase 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:21,341,530...21,409,535
Ensembl chr21:21,265,484...21,408,416
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PALLD
palladin, cytoskeletal associated protein
located_in
ISO
(PMID:11598191)
HGNC-UCL
PMID:11598191
NCBI chr25:19,147,310...19,568,712
Ensembl chr25:19,146,898...19,553,679
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PAWR
pro-apoptotic WT1 regulator
located_in
ISO
PMID:16229834
RGD UniProt
PMID:15817164 PMID:16229834
RGD:8554822 RGD:9835355
NCBI chr15:22,114,014...22,159,287
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POF1B
POF1B actin binding protein
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:66,233,225...66,342,297
Ensembl chr X:66,214,255...66,342,904
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PTGES3
prostaglandin E synthase 3
ISO
RGD
PMID:8864660
RGD:5688126
NCBI chr10:885,744...903,814
Ensembl chr10:870,392...909,161
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PTPRCAP
protein tyrosine phosphatase receptor type C associated protein
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:50,031,740...50,034,200
Ensembl chr18:50,027,275...50,050,907
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RAC1
Rac family small GTPase 1
located_in
ISO
(PMID:19625648)
UniProt
PMID:19625648
NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216
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RAC2
Rac family small GTPase 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:27,295,597...27,311,864
Ensembl chr10:27,295,640...27,311,397
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RHOQ
ras homolog family member Q
located_in
ISO
(PMID:10445846)
BHF-UCL
PMID:10445846
NCBI chr10:48,766,623...48,807,198
Ensembl chr10:48,768,191...48,804,129
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SH2B2
SH2B adaptor protein 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:7,795,756...7,820,010
Ensembl chr 6:7,795,373...7,819,843
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SHROOM4
shroom family member 4
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:43,366,921...43,639,525
Ensembl chr X:43,369,472...43,639,302
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SPTBN4
spectrin beta, non-erythrocytic 4
located_in
ISO
(MGI:2181223|PMID:11807096)
BHF-UCL
PMID:11807096
MGI:2181223
NCBI chr 1:113,167,251...113,243,071
Ensembl chr 1:113,168,484...113,240,934
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SRC
SRC proto-oncogene, non-receptor tyrosine kinase
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
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TEK
TEK receptor tyrosine kinase
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:45,278,375...45,377,300
Ensembl chr11:45,278,891...45,409,093
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TFPT
TCF3 fusion partner
located_in
ISO
PMID:16229834
UniProt
PMID:16229834
RGD:8554822
NCBI chr 1:103,090,723...103,098,601
Ensembl chr 1:102,989,360...103,098,573
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TMOD1
tropomodulin 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:54,853,205...54,914,236
Ensembl chr11:54,853,204...54,912,773
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TPM4
tropomyosin 4
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr20:46,354,808...46,376,489
Ensembl chr20:46,355,736...46,376,425
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TSC1
TSC complex subunit 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:51,409,307...51,459,546
Ensembl chr 9:51,425,937...51,454,677
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VCL
vinculin
located_in
ISO
RGD
PMID:15506980
RGD:1624304
NCBI chr 4:24,404,279...24,518,977
Ensembl chr 4:24,404,319...24,518,633
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VPS11
VPS11 core subunit of CORVET and HOPS complexes
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:14,776,975...14,786,736
Ensembl chr 5:14,776,976...14,786,692
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VPS16
VPS16 core subunit of CORVET and HOPS complexes
located_in
ISO
(PMID:14668490)
MGI
PMID:14668490
NCBI chr24:18,401,440...18,424,605
Ensembl chr24:18,399,572...18,424,510
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VPS18
VPS18 core subunit of CORVET and HOPS complexes
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr30:8,027,877...8,036,773
Ensembl chr30:8,027,128...8,036,153
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WAS
WASP actin nucleation promoting factor
located_in
ISO
(PMID:8625410)
CAFA
PMID:8625410
NCBI chr X:41,882,240...41,890,053
Ensembl chr X:41,882,875...41,890,058
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WHRN
whirlin
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:68,617,383...68,699,824
Ensembl chr11:68,617,377...68,699,977
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WIPF1
WAS/WASL interacting protein family member 1
located_in
ISO IEA
RGD Ensembl
PMID:11687573
GO_REF:0000107 RGD:634538
NCBI chr36:18,574,298...18,653,255
Ensembl chr36:18,576,813...18,697,103
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YES1
YES proto-oncogene 1, Src family tyrosine kinase
located_in
ISO
(PMID:17623777)
MGI
PMID:17623777
NCBI chr 7:67,532,790...67,598,285
Ensembl chr 7:67,532,790...67,598,285
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ARPC2
actin related protein 2/3 complex subunit 2
ISO
RGD
PMID:18256280
RGD:2306202
NCBI chr37:24,914,389...24,935,998
Ensembl chr37:24,914,642...24,935,824
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ACTG1
actin gamma 1
part_of
ISO
(PMID:18796539)
MGI
PMID:18796539
NCBI chr 9:635,978...638,328
Ensembl chr 9:635,978...638,328
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APC2
APC regulator of WNT signaling pathway 2
part_of located_in
IEA ISO
(PMID:25753423)
Ensembl UniProt
PMID:25753423
GO_REF:0000107
NCBI chr20:57,380,472...57,395,249
Ensembl chr20:57,380,460...57,395,226
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ARPC2
actin related protein 2/3 complex subunit 2
ISO
RGD
PMID:10797548
RGD:11049163
NCBI chr37:24,914,389...24,935,998
Ensembl chr37:24,914,642...24,935,824
G
ARPC3
actin related protein 2/3 complex subunit 3
ISO
RGD
PMID:10797548
RGD:11049163
NCBI chr26:8,267,123...8,277,779
Ensembl chr26:8,267,196...8,277,688
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BLOC1S6
biogenesis of lysosomal organelles complex 1 subunit 6
part_of
ISO
(PMID:19116644)
MGI
PMID:19116644
NCBI chr30:11,861,119...11,949,451
Ensembl chr30:11,811,339...11,937,353
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CARMIL1
capping protein regulator and myosin 1 linker 1
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr35:23,268,438...23,581,794
Ensembl chr35:23,268,723...23,581,403
G
CD2AP
CD2 associated protein
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011
G
DIAPH3
diaphanous related formin 3
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr22:15,573,485...16,078,580
Ensembl chr22:15,573,629...16,079,031
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DPYSL3
dihydropyrimidinase like 3
part_of
ISO
PMID:16181627
UniProt
PMID:16181627
RGD:8553533
NCBI chr 2:41,687,725...41,809,402
Ensembl chr 2:41,690,845...41,802,376
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DUSP22
dual specificity phosphatase 22
part_of
ISO
(PMID:20018849)
ARUK-UCL
PMID:20018849
NCBI chr35:678,320...733,225
Ensembl chr35:678,155...732,397
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ESPN
espin
part_of
ISO
PMID:8799813
UniProt
PMID:8799813
RGD:632658
NCBI chr 5:60,285,185...60,316,261
Ensembl chr 5:60,285,312...60,315,676
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JAM3
junctional adhesion molecule 3
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:1,082,619...1,165,188
Ensembl chr 5:1,084,560...1,165,121
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KPTN
kaptin, actin binding protein
part_of located_in
IEA ISO
(PMID:24239382)
Ensembl UniProt
PMID:24239382
GO_REF:0000107
NCBI chr 1:108,535,140...108,544,405
Ensembl chr 1:108,535,681...108,543,164
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MAP3K1
mitogen-activated protein kinase kinase kinase 1
part_of
ISO
(PMID:25224220)
MGI
PMID:25224220
NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209
G
MYO18B
myosin XVIIIB
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr26:19,520,287...19,776,007
Ensembl chr26:19,536,778...19,773,326
G
MYO1A
myosin IA
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr10:1,159,816...1,194,452
Ensembl chr10:1,159,812...1,193,153
G
MYO1C
myosin IC
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:45,635,295...45,658,226
Ensembl chr 9:45,636,208...45,658,035
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MYO1F
myosin IF
part_of
ISO
(PMID:17023661)
MGI
PMID:17023661
NCBI chr20:53,054,583...53,088,593
Ensembl chr20:53,054,585...53,089,115
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MYO3A
myosin IIIA
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:7,455,125...7,695,483
Ensembl chr 2:7,455,625...7,696,043
G
MYO6
myosin VI
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr12:37,359,200...37,502,342
Ensembl chr12:37,413,570...37,500,724
G
NCKAP1
NCK associated protein 1
part_of
ISO
(MGI:5897521|PMID:27927633)
BHF-UCL
PMID:27927633
MGI:5897521
NCBI chr36:25,965,243...26,054,775
Ensembl chr36:25,965,938...26,054,760
G
PDLIM4
PDZ and LIM domain 4
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr11:20,570,839...20,587,185
Ensembl chr11:20,570,833...20,585,594
G
RAC3
Rac family small GTPase 3
part_of
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:293,260...295,990
G
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1 like
part_of
IBA
GO_Central
GO_REF:0000033
NCBI chr26:27,994,278...28,127,383
Ensembl chr26:28,025,987...28,125,695
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all