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ONTOLOGY REPORT - ANNOTATIONS


Term:eukaryotic translation initiation factor 3 complex
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Accession:GO:0005852 term browser browse the term
Definition:A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Synonyms:exact_synonym: eIF-3;   eIF3


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eukaryotic translation initiation factor 3 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 JBrowse link X 123,081,262 123,143,509 RGD:13508589
G DDX3X DEAD-box helicase 3 X-linked JBrowse link X 35,759,367 35,789,759 RGD:9068941
G EIF3A eukaryotic translation initiation factor 3 subunit A JBrowse link 28 29,290,668 29,326,851 RGD:9068941
G EIF3B eukaryotic translation initiation factor 3 subunit B JBrowse link 6 14,780,318 14,802,938 RGD:13508589
G EIF3D eukaryotic translation initiation factor 3 subunit D JBrowse link 10 27,890,913 27,904,887 RGD:13508589
G EIF3E eukaryotic translation initiation factor 3 subunit E JBrowse link 13 8,834,724 8,887,818 RGD:13508589
G EIF3F eukaryotic translation initiation factor 3 subunit F JBrowse link 21 31,514,930 31,525,651 RGD:9068941
G EIF3G eukaryotic translation initiation factor 3 subunit G JBrowse link 20 50,941,413 50,946,042 RGD:13508589
G EIF3H eukaryotic translation initiation factor 3 subunit H JBrowse link 13 16,105,960 16,201,902 RGD:13508589
G EIF3I eukaryotic translation initiation factor 3 subunit I JBrowse link 2 68,977,359 68,986,004 RGD:9068941
G EIF3J eukaryotic translation initiation factor 3 subunit J JBrowse link 30 11,207,620 11,233,106 RGD:13508589
G EIF3K eukaryotic translation initiation factor 3 subunit K JBrowse link 1 114,433,373 114,443,911 RGD:13508589
G EIF3L eukaryotic translation initiation factor 3 subunit L JBrowse link 10 26,757,639 26,784,908 RGD:13508589
G EIF3M eukaryotic translation initiation factor 3 subunit M JBrowse link 18 34,944,181 35,036,686 RGD:13508589
G LOC479795 eukaryotic translation initiation factor 3 subunit C JBrowse link 6 18,276,824 18,299,336 RGD:13508589
G LOC607979 eukaryotic translation initiation factor 3, subunit L pseudogene JBrowse link 32 12,786,465 12,788,360 RGD:13508589
eukaryotic translation initiation factor 3 complex, eIF3e term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EIF3A eukaryotic translation initiation factor 3 subunit A JBrowse link 28 29,290,668 29,326,851 RGD:13508589
G EIF3E eukaryotic translation initiation factor 3 subunit E JBrowse link 13 8,834,724 8,887,818 RGD:13508589
eukaryotic translation initiation factor 3 complex, eIF3m term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EIF3A eukaryotic translation initiation factor 3 subunit A JBrowse link 28 29,290,668 29,326,851 RGD:13508589
G EIF3B eukaryotic translation initiation factor 3 subunit B JBrowse link 6 14,780,318 14,802,938 RGD:13508589
G EIF3D eukaryotic translation initiation factor 3 subunit D JBrowse link 10 27,890,913 27,904,887 RGD:13508589
G EIF3F eukaryotic translation initiation factor 3 subunit F JBrowse link 21 31,514,930 31,525,651 RGD:13508589
G EIF3H eukaryotic translation initiation factor 3 subunit H JBrowse link 13 16,105,960 16,201,902 RGD:13508589
G EIF3I eukaryotic translation initiation factor 3 subunit I JBrowse link 2 68,977,359 68,986,004 RGD:13508589
G EIF3M eukaryotic translation initiation factor 3 subunit M JBrowse link 18 34,944,181 35,036,686 RGD:13508589
G LOC479795 eukaryotic translation initiation factor 3 subunit C JBrowse link 6 18,276,824 18,299,336 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16224
    protein-containing complex 5105
      eukaryotic translation initiation factor 3 complex 16
        eukaryotic translation initiation factor 3 complex, eIF3e 2
        eukaryotic translation initiation factor 3 complex, eIF3m 8
Path 2
Term Annotations click to browse term
  cellular_component 16224
    intracellular 12304
      cytoplasm 9382
        eukaryotic translation initiation factor 3 complex 16
          eukaryotic translation initiation factor 3 complex, eIF3e 2
          eukaryotic translation initiation factor 3 complex, eIF3m 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.