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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA cleavage and polyadenylation specificity factor complex
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Accession:GO:0005847 term browser browse the term
Definition:A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
Synonyms:narrow_synonym: CPF complex;   CPSF complex
 related_synonym: CFII complex;   cleavage and polyadenylylation specificity factor activity

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mRNA cleavage and polyadenylation specificity factor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpsf1 cleavage and polyadenylation specific factor 1 part_of ISO (PMID:21102410), (PMID:7590244) UniProt PMID:7590244 PMID:21102410 NCBI chrNW_004624735:12,444,371...12,457,864
Ensembl chrNW_004624735:12,444,386...12,457,864 		JBrowse link
G Cpsf2 cleavage and polyadenylation specific factor 2 part_of IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624734:8,737,023...8,769,088
Ensembl chrNW_004624734:8,736,911...8,768,583 		JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624969:265,457...290,514
Ensembl chrNW_004624969:265,117...290,361 		JBrowse link
G Cpsf4 cleavage and polyadenylation specific factor 4 part_of IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624740:32,860,217...32,876,878
Ensembl chrNW_004624740:32,860,137...32,876,878 		JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 part_of ISO (PMID:23187700) UniProt PMID:23187700 NCBI chrNW_004624948:53,317...83,983
Ensembl chrNW_004624948:56,246...84,051 		JBrowse link
G Cpsf7 cleavage and polyadenylation specific factor 7 part_of ISO (PMID:23187700) UniProt PMID:23187700 NCBI chrNW_004624926:802,033...822,372 JBrowse link
G Csnk1a1 casein kinase 1 alpha 1 located_in ISO (PMID:18305108) UniProt PMID:18305108 NCBI chrNW_004624774:8,815,021...8,862,657
Ensembl chrNW_004624774:8,815,023...8,862,878 		JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624902:1,755,308...1,780,826 JBrowse link
G Cstf2t cleavage stimulation factor subunit 2 tau variant part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624791:11,924,945...11,929,106
Ensembl chrNW_004624791:11,925,197...11,927,188 		JBrowse link
G Fip1l1 factor interacting with PAPOLA and CPSF1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624761:16,067,962...16,145,116
Ensembl chrNW_004624761:16,071,097...16,145,052 		JBrowse link
G Nudt21 nudix hydrolase 21 part_of ISO (PMID:23187700) UniProt PMID:23187700 NCBI chrNW_004624757:115,249...130,775
Ensembl chrNW_004624757:114,844...130,097 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase type 1 alpha located_in ISO (PMID:18305108) UniProt PMID:18305108 NCBI chrNW_004624772:18,616,095...18,658,016
Ensembl chrNW_004624772:18,616,121...18,658,286 		JBrowse link
G Sympk symplekin scaffold protein part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624832:7,351,303...7,394,337
Ensembl chrNW_004624832:7,354,272...7,394,255 		JBrowse link
G Tut1 terminal uridylyl transferase 1, U6 snRNA-specific part_of
located_in 		ISO (PMID:21102410)
(PMID:18305108) 		UniProt PMID:18305108 PMID:21102410 NCBI chrNW_004624926:1,113,331...1,123,930
Ensembl chrNW_004624926:1,112,309...1,123,959 		JBrowse link
G Wdr33 WD repeat domain 33 part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624732:14,183,734...14,280,825
Ensembl chrNW_004624732:14,183,132...14,280,795 		JBrowse link
G Zc3h3 zinc finger CCCH-type containing 3 part_of ISO (PMID:16115198) MGI PMID:16115198 NCBI chrNW_004624735:13,230,576...13,320,068
Ensembl chrNW_004624735:13,230,642...13,319,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18608
    protein-containing complex 6059
      nuclear protein-containing complex 1753
        mRNA cleavage factor complex 20
          mRNA cleavage and polyadenylation specificity factor complex 16
Path 2
Term Annotations click to browse term
  cellular_component 18608
    cellular anatomical structure 18473
      organelle 13034
        membrane-bounded organelle 11918
          intracellular membrane-bounded organelle 11377
            nucleus 7395
              nuclear protein-containing complex 1753
                mRNA cleavage factor complex 20
                  mRNA cleavage and polyadenylation specificity factor complex 16
paths to the root