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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear cap binding complex
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Accession:GO:0005846 term browser browse the term
Definition:A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
Comment:Note that this complex can be found in the cytoplasm as well as the nucleus.
Synonyms:narrow_synonym: NCBP-NIP1 complex;   mRNA cap binding complex;   snRNA cap binding complex
 related_synonym: CBC


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nuclear cap binding complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncbp1 nuclear cap binding protein subunit 1 part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:9933612, PMID:21873635 RGD:9684949, RGD:13792537 NCBI chr 5:61,734,118...61,767,098
Ensembl chr 5:61,734,118...61,766,481
JBrowse link
G Ncbp2 nuclear cap binding protein subunit 2 part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:9933612, PMID:21873635 RGD:9684949, RGD:13792537 NCBI chr11:72,071,838...72,103,087
Ensembl chr11:72,921,282...72,929,003
Ensembl chr11:72,921,282...72,929,003
JBrowse link
G Snupn snurportin 1 TAS RGD PMID:10209022 RGD:1331354 NCBI chr 8:61,614,798...61,654,809
Ensembl chr 8:61,615,650...61,648,390
JBrowse link

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  cellular_component 20011
    protein-containing complex 6011
      intracellular protein-containing complex 769
        nuclear cap binding complex 3
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