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ONTOLOGY REPORT - ANNOTATIONS

Term:heterotrimeric G-protein complex
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Accession:GO:0005834 term browser browse the term
Definition:Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
Comment:See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'.
Synonyms:narrow_synonym: heterotrimeric G-protein GTPase, alpha-subunit;   heterotrimeric G-protein GTPase, beta-subunit;   heterotrimeric G-protein GTPase, gamma-subunit
 related_synonym: heterotrimeric G-protein GTPase activity

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heterotrimeric G-protein complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07033987.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr11:47,090,245...47,090,448 JBrowse link
G Gna11 G protein subunit alpha 11 part_of IBA
IDA		 PMID:21873635
PMID:21812758		 GO_Central
MGI		 PMID:21873635, PMID:21812758 RGD:13792537, RGD:10448949 NCBI chr 7:11,033,400...11,047,284
Ensembl chr 7:11,033,317...11,047,437 		JBrowse link
G Gna12 G protein subunit alpha 12 part_of TAS
IBA		 PMID:21873635 RGD
GO_Central		 PMID:12623966, PMID:21873635 RGD:730287, RGD:13792537 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212 		JBrowse link
G Gna13 G protein subunit alpha 13 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730 		JBrowse link
G Gna14 G protein subunit alpha 14 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:235,165,775...235,347,986
Ensembl chr 1:235,166,718...235,347,937 		JBrowse link
G Gna15 G protein subunit alpha 15 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251 		JBrowse link
G Gnai1 G protein subunit alpha i1 part_of TAS
IBA		 PMID:21873635 RGD
GO_Central		 PMID:11923410, PMID:21873635 RGD:625670, RGD:13792537 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883 		JBrowse link
G Gnai2 G protein subunit alpha i2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Gnai3 G protein subunit alpha i3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749 		JBrowse link
G Gnal G protein subunit alpha L part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630 		JBrowse link
G Gnao1 G protein subunit alpha o1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578 		JBrowse link
G Gnaq G protein subunit alpha q part_of TAS
IBA
IDA		 PMID:21873635
PMID:21812758		 RGD
GO_Central
MGI		 PMID:12900409, PMID:21873635, PMID:21812758 RGD:1299289, RGD:13792537, RGD:10448949 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786 		JBrowse link
G Gnas GNAS complex locus part_of IDA
IBA		 PMID:18403039
PMID:21873635		 RGD
BHF-UCL
GO_Central		 PMID:15297467, PMID:18403039, PMID:21873635 RGD:1580407, RGD:8553387, RGD:13792537 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Gnat1 G protein subunit alpha transducin 1 part_of IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:11931744, PMID:21873635 RGD:1599009, RGD:13792537 NCBI chr 8:116,433,302...116,438,038
Ensembl chr 8:116,433,302...116,438,038 		JBrowse link
G Gnat2 G protein subunit alpha transducin 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:210,880,754...210,890,765
Ensembl chr 2:210,880,777...210,889,881 		JBrowse link
G Gnat3 G protein subunit alpha transducin 3 part_of IBA
ISO		 PMID:21873635
PR:P62874|PR:Q9JMF3 (MGI:1932393|PMID:10570481)		 RGD PMID:10570481, PMID:21873635 MGI:1932393, RGD:13792537 NCBI chr 4:13,827,764...13,878,126
Ensembl chr 4:13,827,756...13,878,126 		JBrowse link
G Gnaz G protein subunit alpha z part_of TAS
IBA		 PMID:21873635 RGD
GO_Central		 PMID:16157560, PMID:21873635 RGD:1578519, RGD:13792537 NCBI chr20:14,593,072...14,644,020
Ensembl chr20:14,593,819...14,620,019 		JBrowse link
G Gnb1 G protein subunit beta 1 part_of TAS
ISO
IDA
IBA		 PR:Q3V3I2|PR:Q9JMF3 (MGI:1932393|PMID:10570481)
PMID:21812758
PMID:21873635		 RGD PMID:10570481, PMID:9622245, PMID:21812758, PMID:21873635, PMID:11931744 MGI:1932393, RGD:632972, RGD:10448949, RGD:13792537, RGD:1599009 NCBI chr 5:172,914,025...172,981,403
Ensembl chr 5:172,934,990...172,979,986 		JBrowse link
G Gnb2 G protein subunit beta 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096 		JBrowse link
G Gnb3 G protein subunit beta 3 part_of IBA
ISO		 PMID:21873635
PR:Q9JMF3 (MGI:1932393|PMID:10570481)		 RGD PMID:10570481, PMID:21873635 MGI:1932393, RGD:13792537 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262 		JBrowse link
G Gnb4 G protein subunit beta 4 part_of IBA
ISO		 PMID:21873635
PR:Q9JMF3 (MGI:1932393|PMID:10570481)		 RGD PMID:10570481, PMID:21873635 MGI:1932393, RGD:13792537 NCBI chr 2:118,978,965...119,007,877
Ensembl chr 2:118,978,973...119,007,835 		JBrowse link
G Gnb5 G protein subunit beta 5 part_of TAS
IBA		 PMID:21873635 RGD
GO_Central		 PMID:9622245, PMID:21873635 RGD:632972, RGD:13792537 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184 		JBrowse link
G Gng10 G protein subunit gamma 10 part_of IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:9622245, PMID:21873635 RGD:632972, RGD:13792537 NCBI chr 5:76,182,100...76,189,014
Ensembl chr 5:76,182,121...76,189,013 		JBrowse link
G Gng11 G protein subunit gamma 11 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:28,989,170...28,994,610
Ensembl chr 4:28,989,115...28,993,621
Ensembl chr 4:28,989,115...28,993,621 		JBrowse link
G Gng12 G protein subunit gamma 12 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102 		JBrowse link
G Gng13 G protein subunit gamma 13 part_of ISO PR: Q9JMF3|PR:P29387|PR:P62874|PR:Q3V3I2 (MGI:1932393|PMID:10570481) RGD PMID:10570481 MGI:1932393 NCBI chr10:15,088,935...15,090,839
Ensembl chr10:15,088,935...15,090,839 		JBrowse link
G Gng14 G protein subunit gamma 14 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:26,180,749...26,182,197
Ensembl chr19:26,181,143...26,181,449 		JBrowse link
G Gng2 G protein subunit gamma 2 part_of IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:9622245, PMID:21873635 RGD:632972, RGD:13792537 NCBI chr15:4,748,242...4,853,555
Ensembl chr15:4,850,122...4,853,555 		JBrowse link
G Gng3 G protein subunit gamma 3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:225,033,921...225,035,687
Ensembl chr 1:225,033,921...225,035,687 		JBrowse link
G Gng4 G protein subunit gamma 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:90,266,571...90,316,278
Ensembl chr17:90,266,794...90,315,492 		JBrowse link
G Gng5 G protein subunit gamma 5 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:252,359,976...252,368,473
Ensembl chr 2:252,359,976...252,368,473 		JBrowse link
G Gng7 G protein subunit gamma 7 part_of NAS
IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro PMID:7807587, PMID:21873635 GO_REF:0000002, RGD:61610, RGD:13792537 NCBI chr 7:11,565,740...11,629,519
Ensembl chr 7:11,582,984...11,628,929 		JBrowse link
G Gng8 G protein subunit gamma 8 part_of TAS
IBA		 PMID:21873635 RGD
GO_Central		 PMID:7896821, PMID:21873635 RGD:728592, RGD:13792537 NCBI chr 1:78,818,360...78,822,224
Ensembl chr 1:78,818,404...78,822,224 		JBrowse link
G Gngt1 G protein subunit gamma transducin 1 part_of IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:11931744, PMID:21873635 RGD:1599009, RGD:13792537 NCBI chr 4:28,972,339...28,975,419
Ensembl chr 4:28,972,434...28,975,419 		JBrowse link
G Gngt2 G protein subunit gamma transducin 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,654,321...83,658,601
Ensembl chr10:83,655,460...83,658,589 		JBrowse link
G LOC108349548 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:78,545,963...78,546,461
Ensembl chr 1:78,546,012...78,546,218
Ensembl chr 2:78,546,012...78,546,218 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20137
    cellular anatomical entity 19833
      intracellular anatomical structure 14405
        extrinsic component of cytoplasmic side of plasma membrane 107
          heterotrimeric G-protein complex 36
Path 2
Term Annotations click to browse term
  cellular_component 20137
    cellular anatomical entity 19833
      membrane 10004
        side of membrane 774
          cytoplasmic side of membrane 214
            cytoplasmic side of plasma membrane 175
              extrinsic component of cytoplasmic side of plasma membrane 107
                heterotrimeric G-protein complex 36
paths to the root