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ONTOLOGY REPORT - ANNOTATIONS

Term:smooth endoplasmic reticulum
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Accession:GO:0005790 term browser browse the term
Definition:The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
Synonyms:exact_synonym: SER;   smooth ER
 xref: NIF_Subcellular:sao710427438;   Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum


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smooth endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein located_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Calr calreticulin located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Canx calnexin located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 IDA RGD PMID:12112448 RGD:11566026 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gabarap GABA type A receptor-associated protein located_in ISO (MGI:1929594|PMID:11146101) RGD PMID:11146101 MGI:1929594 NCBI chr10:54,714,834...54,717,769
Ensembl chr10:54,714,198...54,717,765 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hyou1 hypoxia up-regulated 1 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Jph4 junctophilin 4 located_in ISO (MGI:3714568|PMID:17347645) RGD PMID:17347645 MGI:3714568 NCBI chr15:28,579,579...28,588,903
Ensembl chr15:28,571,568...28,587,573 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 IDA RGD PMID:18076085 RGD:7247433 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 located_in ISO (MGI:3714568|PMID:17347645) RGD PMID:17347645 MGI:3714568 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:15623521 RGD:1625439 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 located_in ISO (MGI:3629289|PMID:16606357) RGD PMID:16606357 MGI:3629289 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Myo1d myosin ID IDA RGD PMID:15809075 RGD:2314421 NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349 		JBrowse link
G Myo5a myosin VA is_active_in ISO (MGI:4939562|PMID:21151132) RGD PMID:21151132 MGI:4939562 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Plcb4 phospholipase C, beta 4 located_in
is_active_in		 IEA
ISO		 GO_REF:0000107
(MGI:3603702|PMID:15579147)		 Ensembl
RGD		 PMID:15579147 GO_REF:0000107 MGI:3603702 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Ppib peptidylprolyl isomerase B located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Prdx4 peroxiredoxin 4 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Psen1 presenilin 1 colocalizes_with
located_in		 ISO (PMID:10508860)
(PMID:9632714)		 RGD PMID:9632714 PMID:10508860 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Rpl10 ribosomal protein L10 colocalizes_with ISO (PMID:10508860)
(MGI:6316562|PMID:10508860)		 RGD PMID:10508860 MGI:6316562 NCBI chr  X:152,054,547...152,056,757
Ensembl chr  X:152,054,452...152,056,761 		JBrowse link
G Rtn1 reticulon 1 located_in IDA PMID:23454728 MGI PMID:23454728 RGD:8693349 NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436 		JBrowse link
G Ryr1 ryanodine receptor 1 located_in
is_active_in		 ISO
IBA		 (MGI:5519014|PMID:23454728)
PMID:21873635		 RGD PMID:23454728 PMID:21873635 MGI:5519014, RGD:13792537 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 located_in
is_active_in		 IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(MGI:5519014|PMID:23454728)		 Ensembl
RGD		 PMID:23454728 PMID:21873635 GO_REF:0000107 MGI:5519014, RGD:13792537 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
G Sri sorcin IDA RGD PMID:9378856 RGD:7327212 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077 		JBrowse link
G Syvn1 synoviolin 1 located_in ISO (PMID:16186510) RGD PMID:16186510 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Th tyrosine hydroxylase located_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
smooth endoplasmic reticulum membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B IDA RGD PMID:234468 RGD:2313431 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase located_in ISO (PMID:14697341) RGD PMID:14697341 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 is_active_in IDA PMID:1311032 SynGO PMID:1311032 RGD:13702190 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682 		JBrowse link
G Stx17 syntaxin 17 located_in IDA PMID:10930465 UniProt PMID:10930465 RGD:8553381 NCBI chr 5:62,446,138...62,506,108
Ensembl chr 5:62,446,187...62,504,451 		JBrowse link
G Svip small VCP interacting protein located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116 		JBrowse link
G Ttyh1 tweety family member 1 located_in
is_active_in		 ISO
IBA		 (MGI:4461352|PMID:20568244)
PMID:21873635		 RGD PMID:20568244 PMID:21873635 MGI:4461352, RGD:13792537 NCBI chr 1:70,053,312...70,071,872
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19189
    cellular anatomical entity 18930
      endomembrane system 4043
        endoplasmic reticulum 1771
          smooth endoplasmic reticulum 39
            smooth endoplasmic reticulum cisterna + 0
            smooth endoplasmic reticulum lumen 0
            smooth endoplasmic reticulum membrane + 7
Path 2
Term Annotations click to browse term
  cellular_component 19189
    cellular anatomical entity 18930
      intracellular anatomical structure 14075
        intracellular organelle 12462
          intracellular membrane-bounded organelle 11100
            endoplasmic reticulum 1771
              smooth endoplasmic reticulum 39
                smooth endoplasmic reticulum cisterna + 0
                smooth endoplasmic reticulum lumen 0
                smooth endoplasmic reticulum membrane + 7
paths to the root