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ONTOLOGY REPORT - ANNOTATIONS

Term:smooth endoplasmic reticulum
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Accession:GO:0005790 term browser browse the term
Definition:The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
Synonyms:exact_synonym: SER;   smooth ER
 xref: NIF_Subcellular:sao710427438;   Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum

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smooth endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Calr calreticulin IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Canx calnexin IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883 		JBrowse link
G Fmr1 FMRP translational regulator 1 IDA RGD PMID:12112448 RGD:11566026 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314 		JBrowse link
G Gabarap GABA type A receptor-associated protein ISO (MGI:1929594|PMID:11146101) RGD PMID:11146101 MGI:1929594 NCBI chr10:56,601,288...56,604,223
Ensembl chr10:56,601,288...56,604,221 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hyou1 hypoxia up-regulated 1 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910 		JBrowse link
G Jph4 junctophilin 4 IEA
ISO		 GO_REF:0000107
(MGI:3714568|PMID:17347645)		 Ensembl
RGD		 PMID:17347645 GO_REF:0000107, MGI:3714568 NCBI chr15:33,767,116...33,777,289
Ensembl chr15:33,768,595...33,775,109 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 IDA RGD PMID:18076085 RGD:7247433 NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 ISO (MGI:3714568|PMID:17347645) RGD PMID:17347645 MGI:3714568 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257 		JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:15623521 RGD:1625439 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 ISO (MGI:3629289|PMID:16606357) RGD PMID:16606357 MGI:3629289 NCBI chr10:14,259,394...14,299,276
Ensembl chr10:14,260,787...14,299,167 		JBrowse link
G Myo1d myosin ID IDA RGD PMID:15809075 RGD:2314421 NCBI chr10:67,866,939...68,142,864
Ensembl chr10:67,866,940...68,142,864 		JBrowse link
G Myo5a myosin VA ISO (MGI:4939562|PMID:21151132) RGD PMID:21151132 MGI:4939562 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652 		JBrowse link
G Plcb4 phospholipase C, beta 4 IEA
ISO		 GO_REF:0000107
(MGI:3603702|PMID:15579147)		 Ensembl
RGD		 PMID:15579147 GO_REF:0000107, MGI:3603702 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746 		JBrowse link
G Ppib peptidylprolyl isomerase B IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 8:71,719,681...71,725,538
Ensembl chr 8:71,719,563...71,725,562 		JBrowse link
G Prdx4 peroxiredoxin 4 IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr  X:43,495,453...43,512,994
Ensembl chr  X:43,497,763...43,512,991 		JBrowse link
G Psen1 presenilin 1 colocalizes_with ISO (PMID:10508860)
(PMID:9632714)		 RGD PMID:9632714, PMID:10508860 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
G Rpl10 ribosomal protein L10 colocalizes_with ISO (PMID:10508860)
(MGI:6316562|PMID:10508860)		 RGD PMID:10508860 MGI:6316562 NCBI chr  X:156,438,251...156,440,461
Ensembl chr  X:156,438,251...156,440,461 		JBrowse link
G Rtn1 reticulon 1 IDA PMID:23454728 MGI PMID:23454728 RGD:8693349 NCBI chr 6:94,951,016...95,177,477
Ensembl chr 6:94,951,020...95,061,174 		JBrowse link
G Ryr1 ryanodine receptor 1 IEA
ISO
IBA		 GO_REF:0000107
(MGI:5519014|PMID:23454728)
PMID:21873635		 Ensembl
RGD		 PMID:23454728, PMID:21873635 GO_REF:0000107, MGI:5519014, RGD:13792537 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101 		JBrowse link
G Ryr2 ryanodine receptor 2 IEA
ISO
IBA		 GO_REF:0000107
(MGI:5519014|PMID:23454728)
PMID:21873635		 Ensembl
RGD		 PMID:23454728, PMID:21873635 GO_REF:0000107, MGI:5519014, RGD:13792537 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606 		JBrowse link
G Ryr3 ryanodine receptor 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:104,117,307...104,665,151
Ensembl chr 3:104,118,063...104,504,204 		JBrowse link
G Sri sorcin IDA RGD PMID:9378856 RGD:7327212 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983 		JBrowse link
G Syvn1 synoviolin 1 ISO (PMID:16186510) RGD PMID:16186510 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886 		JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
smooth endoplasmic reticulum membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B IDA RGD PMID:234468 RGD:2313431 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase ISO (PMID:14697341) RGD PMID:14697341 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IDA PMID:1311032 SynGO PMID:1311032 RGD:13702190 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882 		JBrowse link
G Stx17 syntaxin 17 IDA PMID:10930465 UniProt PMID:10930465 RGD:8553381 NCBI chr 5:63,866,346...63,926,276
Ensembl chr 5:63,870,432...63,922,730 		JBrowse link
G Svip small VCP interacting protein IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:107,368,117...107,373,807
Ensembl chr 1:107,368,117...107,373,807 		JBrowse link
G Ttyh1 tweety family member 1 IBA
ISO		 PMID:21873635
(MGI:4461352|PMID:20568244)		 RGD PMID:20568244, PMID:21873635 MGI:4461352, RGD:13792537 NCBI chr 1:73,734,614...73,753,157
Ensembl chr 1:73,734,624...73,753,128 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      endomembrane system 4011
        endoplasmic reticulum 1760
          smooth endoplasmic reticulum 39
            smooth endoplasmic reticulum cisterna + 0
            smooth endoplasmic reticulum lumen 0
            smooth endoplasmic reticulum membrane + 7
Path 2
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      organelle 13274
        membrane-bounded organelle 11259
          intracellular membrane-bounded organelle 10515
            endoplasmic reticulum 1760
              smooth endoplasmic reticulum 39
                smooth endoplasmic reticulum cisterna + 0
                smooth endoplasmic reticulum lumen 0
                smooth endoplasmic reticulum membrane + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.