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ONTOLOGY REPORT - ANNOTATIONS

Term:multivesicular body
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Accession:GO:0005771 term browser browse the term
Definition:A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
Synonyms:exact_synonym: MVB;   MVE;   multivesicular endosome
 xref: NIF_Subcellular:sao2045955158


show annotations for term's descendants           Sort by:
multivesicular body term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 IDA RGD PMID:977936 RGD:2299977 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 located_in ISO (PMID:24603074), (PMID:25392495) RGD PMID:24603074 PMID:25392495 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
G Bace1 beta-secretase 1 located_in ISO (PMID:24612608) RGD PMID:24612608 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 part_of ISO (PMID:22072966) RGD PMID:22072966 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Cd63 Cd63 molecule located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178 		JBrowse link
G Cd74 CD74 molecule located_in ISO (MGI:3033879|PMID:11854359) RGD PMID:11854359 MGI:3033879 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd79a CD79a molecule located_in ISO (MGI:3033879|PMID:11854359) RGD PMID:11854359 MGI:3033879 NCBI chr 1:80,493,520...80,497,936
Ensembl chr 1:80,493,581...80,497,935 		JBrowse link
G Chmp1a charged multivesicular body protein 1A is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436 		JBrowse link
G Chmp1b2 charged multivesicular body protein 1B2 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,860,409...72,901,232
Ensembl chr  X:72,860,409...72,901,246 		JBrowse link
G Chmp2a charged multivesicular body protein 2A is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Chmp2b charged multivesicular body protein 2B is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:3,338,007...3,364,357
Ensembl chr11:3,337,494...3,385,181 		JBrowse link
G Chmp3 charged multivesicular body protein 3 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp4b charged multivesicular body protein 4B is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Chmp4bl1 chromatin modifying protein 4B-like 1 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:68,049,742...68,050,791
Ensembl chr 4:68,049,705...68,050,676 		JBrowse link
G Chmp4c charged multivesicular body protein 4C is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668 		JBrowse link
G Chmp5 charged multivesicular body protein 5 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Chmp6 charged multivesicular body protein 6 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Chmp7 charged multivesicular body protein 7 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216 		JBrowse link
G Colec10 collectin subfamily member 10 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein IDA RGD PMID:10524337 RGD:5490549 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IDA Purkinje cells beginning postnatal day 3 RGD PMID:12911751 RGD:1626245 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Cst3 cystatin C IDA RGD PMID:10950881 RGD:2306514 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cst7 cystatin F located_in ISO (PMID:22365146) RGD PMID:22365146 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557 		JBrowse link
G Ctsl cathepsin L located_in ISO (PMID:22365146) RGD PMID:22365146 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ecpas Ecm29 proteasome adaptor and scaffold located_in ISO (PMID:20682791) RGD PMID:20682791 NCBI chr 5:73,601,745...73,714,026
Ensembl chr 5:73,604,533...73,713,860 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gja1 gap junction protein, alpha 1 IDA RGD PMID:16162097 RGD:1582681 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 located_in IDA
IEA
ISO		 GO_REF:0000107
(MGI:3033879|PMID:11854359)		 Ensembl
RGD		 PMID:11854359 PMID:7868367 GO_REF:0000107 MGI:3033879, RGD:4892636 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lrat lecithin retinol acyltransferase located_in IDA PMID:18544127 RGD
UniProt		 PMID:18544127 PMID:18544127 RGD:6893660, RGD:6893660 NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619 		JBrowse link
G Mbl1 mannose binding lectin 1 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha located_in ISO (MGI:5293291|PMID:21502359) RGD PMID:21502359 MGI:5293291 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta located_in ISO (MGI:5293291|PMID:21502359) RGD PMID:21502359 MGI:5293291 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family located_in ISO (PMID:15634213) RGD PMID:15634213 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G RT1-Bb RT1 class II, locus Bb located_in ISO (MGI:3033879|PMID:11854359) RGD PMID:11854359 MGI:3033879 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-DMa RT1 class II, locus DMa located_in ISO (MGI:3033879|PMID:11854359) RGD PMID:11854359 MGI:3033879 NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432 		JBrowse link
G Sftpa1 surfactant protein A1 is_active_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:16187065 PMID:21873635 RGD:4143471, RGD:13792537 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Sftpb surfactant protein B is_active_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:16187065 PMID:21873635 RGD:4143471, RGD:13792537 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436 		JBrowse link
G Sftpc surfactant protein C IDA RGD PMID:16187065 RGD:4143471 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777 		JBrowse link
G Sftpd surfactant protein D is_active_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:16187065 PMID:21873635 RGD:4143471, RGD:13792537 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IDA RGD PMID:12388773 RGD:625707 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 IDA RGD PMID:1881917 RGD:2306204 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sorl1 sortilin related receptor 1 located_in IDA
ISO		 (PMID:21385844) RGD PMID:21385844 PMID:16452683 RGD:1581100 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Steap3 STEAP3 metalloreductase located_in ISO (PMID:15319436) RGD PMID:15319436 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 located_in ISO (PMID:15319436) RGD PMID:15319436 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Vta1 vesicle trafficking 1 is_active_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:9,031,226...9,080,654
Ensembl chr 1:9,032,335...9,080,635 		JBrowse link
G Zp2 zona pellucida glycoprotein 2 located_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:3690518|PMID:17047254)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17047254 GO_REF:0000024 GO_REF:0000107 MGI:3690518 NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288 		JBrowse link
multivesicular body membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745 		JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 located_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000044
(PMID:25627919)		 UniProt
RGD		 PMID:25627919 GO_REF:0000024 GO_REF:0000044 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Cd63 Cd63 molecule located_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:26280656)		 UniProt
Ensembl
RGD		 PMID:26280656 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178 		JBrowse link
G Chmp1a charged multivesicular body protein 1A located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436 		JBrowse link
G Chmp1b charged multivesicular body protein 1B located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr18:60,740,349...60,742,879 JBrowse link
G Chmp2a charged multivesicular body protein 2A located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Chmp2b charged multivesicular body protein 2B located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr11:3,338,007...3,364,357
Ensembl chr11:3,337,494...3,385,181 		JBrowse link
G Chmp3 charged multivesicular body protein 3 located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp4b charged multivesicular body protein 4B located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Chmp4c charged multivesicular body protein 4C located_in ISO
IEA		 (PMID:16554368)
GO_REF:0000107		 RGD
Ensembl		 PMID:16554368 GO_REF:0000107 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668 		JBrowse link
G Chmp5 charged multivesicular body protein 5 located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Chmp6 charged multivesicular body protein 6 located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Chmp7 charged multivesicular body protein 7 located_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta located_in ISS
ISO		 GO_REF:0000024
(PMID:25588945), (PMID:26280656)		 UniProt
RGD		 PMID:25588945 PMID:26280656 GO_REF:0000024 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514 		JBrowse link
G Nsg2 neuronal vesicle trafficking associated 2 located_in ISS
ISO		 GO_REF:0000024
(MGI:70373|PMID:7829526)		 UniProt
RGD		 PMID:7829526 GO_REF:0000024 MGI:70373 NCBI chr10:15,601,594...15,661,441
Ensembl chr10:15,601,596...15,661,441 		JBrowse link
G Pmel premelanosome protein located_in ISO (PMID:11694580) RGD PMID:11694580 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family located_in ISO (PMID:19966785) RGD PMID:19966785 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family located_in ISO (PMID:19966785) RGD PMID:19966785 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 located_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:20719963)		 Ensembl
UniProt
RGD		 PMID:20719963 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471 		JBrowse link
G Sorl1 sortilin related receptor 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Tmem9 transmembrane protein 9 located_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832 		JBrowse link
multivesicular body, internal vesicle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E located_in ISO
ISS
IEA		 (PMID:26387950)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:26387950 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Cd63 Cd63 molecule located_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:21962903), (PMID:26280656), (PMID:26387950)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21962903 PMID:26280656 PMID:26387950 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta located_in ISS
ISO		 GO_REF:0000024
(PMID:26280656)		 UniProt
RGD		 PMID:26280656 GO_REF:0000024 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 located_in ISO (PMID:19640926) RGD PMID:19640926 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Pmel premelanosome protein located_in ISO (PMID:26387950) RGD PMID:26387950 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
multivesicular body, internal vesicle lumen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor located_in ISO (PMID:17714434) RGD PMID:17714434 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20075
    cellular anatomical entity 19914
      endomembrane system 4070
        endosome 914
          late endosome 275
            multivesicular body 63
              multivesicular body lumen 0
              multivesicular body membrane + 24
              multivesicular body, internal vesicle + 6
Path 2
Term Annotations click to browse term
  cellular_component 20075
    cellular anatomical entity 19914
      organelle 13187
        membrane-bounded organelle 11706
          vesicle 2141
            intracellular vesicle 1954
              cytoplasmic vesicle 1948
                endosome 914
                  late endosome 275
                    multivesicular body 63
                      multivesicular body lumen 0
                      multivesicular body membrane + 24
                      multivesicular body, internal vesicle + 6
paths to the root