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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA polymerase II, core complex
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Accession:GO:0005665 term browser browse the term
Definition:RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
Synonyms:exact_synonym: DNA-directed RNA polymerase II, core complex
 broad_synonym: RNA polymerase II complex;   RNAP II complex


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RNA polymerase II, core complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myzap myocardial zonula adherens protein part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:71,411,629...71,499,642
Ensembl chr 9:71,411,629...71,499,642 		JBrowse link
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463 		JBrowse link
G Polr2b polymerase (RNA) II (DNA directed) polypeptide B part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:77,458,331...77,497,175
Ensembl chr 5:77,457,994...77,497,171 		JBrowse link
G Polr2c polymerase (RNA) II (DNA directed) polypeptide C part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 8:95,584,078...95,590,870
Ensembl chr 8:95,584,078...95,600,163 		JBrowse link
G Polr2d polymerase (RNA) II (DNA directed) polypeptide D part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr18:31,922,178...31,929,762
Ensembl chr18:31,922,212...31,929,754 		JBrowse link
G Polr2e polymerase (RNA) II (DNA directed) polypeptide E part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr10:79,871,787...79,875,493
Ensembl chr10:79,871,783...79,875,629 		JBrowse link
G Polr2f polymerase (RNA) II (DNA directed) polypeptide F part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr15:79,025,525...79,035,974
Ensembl chr15:79,025,209...79,035,974 		JBrowse link
G Polr2g polymerase (RNA) II (DNA directed) polypeptide G part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr19:8,770,493...8,775,921
Ensembl chr19:8,770,491...8,775,941 		JBrowse link
G Polr2h polymerase (RNA) II (DNA directed) polypeptide H part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr16:20,536,552...20,541,015
Ensembl chr16:20,536,415...20,541,017 		JBrowse link
G Polr2i polymerase (RNA) II (DNA directed) polypeptide I part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:29,931,499...29,932,812
Ensembl chr 7:29,931,373...29,932,815 		JBrowse link
G Polr2j polymerase (RNA) II (DNA directed) polypeptide J part_of ISO
IBA
IDA		 (PMID:9099876) MGI
GO_Central		 PMID:9099876 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:136,145,545...136,151,801
Ensembl chr 5:136,145,485...136,151,801 		JBrowse link
G Polr2k polymerase (RNA) II (DNA directed) polypeptide K part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr15:36,174,156...36,177,158
Ensembl chr15:36,174,156...36,177,156 		JBrowse link
G Polr2l polymerase (RNA) II (DNA directed) polypeptide L part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:141,051,773...141,055,066
Ensembl chr 7:141,051,773...141,055,045 		JBrowse link
G Polr2m polymerase (RNA) II (DNA directed) polypeptide M part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:71,385,719...71,393,265
Ensembl chr 9:71,385,719...71,393,217 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 28583
    cellular anatomical entity 19615
      nucleoplasm 3822
        RNA polymerase II, holoenzyme 71
          RNA polymerase II, core complex 14
Path 2
Term Annotations click to browse term
  cellular_component 28583
    cellular anatomical entity 19615
      organelle 13529
        membrane-bounded organelle 12544
          intracellular membrane-bounded organelle 11998
            nucleus 7486
              nuclear protein-containing complex 1285
                nuclear DNA-directed RNA polymerase complex 94
                  RNA polymerase II, holoenzyme 71
                    RNA polymerase II, core complex 14
paths to the root