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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA polymerase II, core complex
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Accession:GO:0005665 term browser browse the term
Definition:RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
Synonyms:exact_synonym: DNA-directed RNA polymerase II, core complex
 broad_synonym: RNA polymerase II complex;   RNAP II complex


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RNA polymerase II, core complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC109542.1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 1:196,570,210...196,573,077 JBrowse link
G LOC120098305 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr18:1,257,666...1,258,121
Ensembl chr18:1,257,666...1,258,121 		JBrowse link
G Polr2a RNA polymerase II subunit A part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Polr2b RNA polymerase II subunit B part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916 		JBrowse link
G Polr2c RNA polymerase II subunit C part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945 		JBrowse link
G Polr2d RNA polymerase II subunit D part_of ISO
IBA		 (PMID:9528765), (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9528765 PMID:9852112 GO_REF:0000033 NCBI chr18:23,418,097...23,425,228
Ensembl chr18:23,418,097...23,425,228 		JBrowse link
G Polr2e RNA polymerase II, I and III subunit E part_of ISO
ISS
IEA
IBA		 (PMID:9852112)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 RGD
UniProt
Ensembl
GO_Central
TreeGrafter		 PMID:9852112 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643 		JBrowse link
G Polr2f RNA polymerase II, I and III subunit F part_of TAS
ISO
ISS
IBA		 (PMID:9852112)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:9852112 PMID:10393248 GO_REF:0000024 GO_REF:0000033, RGD:1299534 NCBI chr 7:110,712,528...110,724,234
Ensembl chr 7:110,712,572...110,724,234 		JBrowse link
G Polr2g RNA polymerase II subunit G part_of ISO
ISS
IEA
IBA		 (PMID:9852112)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:9852112 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:205,689,160...205,692,686 		JBrowse link
G Polr2h RNA polymerase II, I and III subunit H part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr11:80,192,017...80,197,468
Ensembl chr11:80,192,032...80,197,515
Ensembl chr10:80,192,032...80,197,515 		JBrowse link
G Polr2i RNA polymerase II subunit I part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr 1:85,483,515...85,484,952
Ensembl chr 1:85,483,515...85,484,952 		JBrowse link
G Polr2j RNA polymerase II subunit J part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033
(PMID:9099876)		 RGD
GO_Central		 PMID:9099876 PMID:9852112 GO_REF:0000033 NCBI chr12:20,543,038...20,548,590
Ensembl chr12:20,543,038...20,548,594 		JBrowse link
G Polr2k RNA polymerase II, I and III subunit K part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr 7:67,347,118...67,359,466
Ensembl chr 7:67,356,113...67,357,668 		JBrowse link
G Polr2k-ps2 RNA polymerase II, I and III subunit K, pseudogene 2 part_of IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:208,943,604...208,944,098
Ensembl chr 1:208,943,798...208,944,121
Ensembl chr 1:208,943,798...208,944,121 		JBrowse link
G Polr2l RNA polymerase II, I and III subunit L part_of ISO
IBA		 (PMID:9852112)
GO_REF:0000033		 RGD
GO_Central		 PMID:9852112 GO_REF:0000033 NCBI chr 1:196,570,051...196,572,060 JBrowse link
G Polr2m RNA polymerase II subunit M part_of ISO UniProtKB:P19387|UniProtKB:P24928|UniProtKB:P30876 (PMID:30190596) RGD PMID:30190596 NCBI chr 8:72,131,992...72,139,423
Ensembl chr 8:72,131,530...72,243,036 		JBrowse link
G Polr2sl1 RNA polymerase II, I and III subunit like 1 part_of IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 4:5,743,067...5,743,270
Ensembl chr 4:5,743,067...5,743,270 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21254
    cellular anatomical entity 21098
      nucleoplasm 3608
        RNA polymerase II, holoenzyme 79
          RNA polymerase II, core complex 17
Path 2
Term Annotations click to browse term
  cellular_component 21254
    cellular anatomical entity 21098
      organelle 14217
        membrane-bounded organelle 12815
          intracellular membrane-bounded organelle 12228
            nucleus 7659
              nuclear protein-containing complex 1373
                nuclear DNA-directed RNA polymerase complex 103
                  RNA polymerase II, holoenzyme 79
                    RNA polymerase II, core complex 17
paths to the root