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ONTOLOGY REPORT - ANNOTATIONS


Term:alpha DNA polymerase:primase complex
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Accession:GO:0005658 term browser browse the term
Definition:A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
Synonyms:exact_synonym: heterotetrameric polymerase alpha holoenzyme
 broad_synonym: primosome
 related_synonym: pol-prim



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alpha DNA polymerase:primase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pola1 DNA polymerase alpha 1, catalytic subunit located_in
part_of
IDA
ISO
IBA
IEA
ISS
IC
(MGI:3687659|PMID:10523676)
(PMID:26975377)
(PMID:2175912), (PMID:22465957), (PMID:26975377), (PMID:8026492)
(MGI:1203906|PMID:9584195), (MGI:6478526|PMID:8026492)
PMID:21873635
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:2175912 PMID:8026492 PMID:9584195 PMID:10523676 PMID:22465957 More... GO_REF:0000024 GO_REF:0000107 MGI:1203906 MGI:3687659 MGI:6478526, RGD:1580605, RGD:13792537, RGD:2307013 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit located_in
part_of
TAS
ISO
ISS
IC
IBA
IEA
(MGI:3687659|PMID:10523676)
(PMID:26975377)
GO_REF:0000024
(PMID:22465957), (PMID:26975377), (PMID:8026492)
(MGI:1203906|PMID:9584195), (MGI:6478526|PMID:8026492)
PMID:21873635
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:8026492 PMID:9584195 PMID:10523676 PMID:22465957 PMID:26975377 More... GO_REF:0000024 GO_REF:0000107 MGI:1203906 MGI:3687659 MGI:6478526, RGD:633584, RGD:2307013, RGD:13792537 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
JBrowse link
G Prim1 DNA primase subunit 1 part_of
located_in
IBA
ISO
PMID:21873635
(MGI:3687659|PMID:10523676)
(PMID:26975377)
(PMID:26975377), (PMID:8026492)
(MGI:6478526|PMID:8026492)
RGD PMID:8026492 PMID:10523676 PMID:26975377 PMID:21873635 MGI:3687659 MGI:6478526, RGD:13792537 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
JBrowse link
G Prim2 DNA primase subunit 2 part_of
located_in
IBA
ISO
ISS
PMID:21873635
(MGI:6478526|PMID:8026492)
(PMID:26975377), (PMID:8026492)
GO_REF:0000024
(MGI:3687659|PMID:10523676)
RGD
UniProt
PMID:8026492 PMID:10523676 PMID:26975377 PMID:21873635 GO_REF:0000024 MGI:3687659 MGI:6478526, RGD:13792537 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      intracellular protein-containing complex 776
        DNA polymerase complex 21
          alpha DNA polymerase:primase complex 4
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      intracellular anatomical structure 14364
        intracellular organelle 12730
          intracellular membrane-bounded organelle 11218
            nucleus 7051
              nuclear lumen 3941
                nuclear chromosome 245
                  nuclear replication fork 37
                    nuclear replisome 23
                      alpha DNA polymerase:primase complex 4
paths to the root