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ONTOLOGY REPORT - ANNOTATIONS


Term:classical-complement-pathway C3/C5 convertase complex
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Accession:GO:0005601 term browser browse the term
Definition:A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.



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classical-complement-pathway C3/C5 convertase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2 complement C2 located_in
part_of
ISO
IBA
(PMID:6906228)
(PMID:21873635)
ComplexPortal
GO_Central
PMID:6906228 PMID:21873635 NCBI chr 7:24,020,590...24,034,042
Ensembl chr 7:23,995,982...24,033,930
JBrowse link
G C4A complement C4A (Rodgers blood group) located_in ISO (PMID:6906228) ComplexPortal PMID:6906228 NCBI chr 7:24,068,019...24,083,060
Ensembl chr 7:24,068,019...24,083,061
JBrowse link
G CFB complement factor B part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,033,740...24,041,179
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17838
    cellular anatomical entity 17613
      extracellular space 1483
        classical-complement-pathway C3/C5 convertase complex 3
Path 2
Term Annotations click to browse term
  cellular_component 17838
    cellular anatomical entity 17613
      extracellular region 2007
        extracellular space 1483
          classical-complement-pathway C3/C5 convertase complex 3
paths to the root