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ONTOLOGY REPORT - ANNOTATIONS


Term:classical-complement-pathway C3/C5 convertase complex
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Accession:GO:0005601 term browser browse the term
Definition:A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.



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classical-complement-pathway C3/C5 convertase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2 complement C2 located_in
part_of
IPI
IBA
(PMID:6906228)
(PMID:21873635)
ComplexPortal
ComplexPortal
GO_Central
PMID:6906228 PMID:21873635 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,673
JBrowse link
G C4A complement C4A (Rodgers blood group) located_in IPI (PMID:6906228) ComplexPortal
ComplexPortal
PMID:6906228 NCBI chr 6:31,982,057...32,002,681
Ensembl chr 6:31,982,057...32,002,681
JBrowse link
G C4B complement C4B (Chido blood group) located_in IPI (PMID:6906228) ComplexPortal
ComplexPortal
PMID:6906228 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G C4B_2 complement component 4B (Chido blood group), copy 2 located_in IPI (PMID:6906228) ComplexPortal
ComplexPortal
PMID:6906228
G CFB complement factor B part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20622
    cellular anatomical entity 20234
      extracellular space 3815
        classical-complement-pathway C3/C5 convertase complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20622
    cellular anatomical entity 20234
      extracellular region 4822
        extracellular space 3815
          classical-complement-pathway C3/C5 convertase complex 5
paths to the root