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ONTOLOGY REPORT - ANNOTATIONS


Term:classical-complement-pathway C3/C5 convertase complex
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Accession:GO:0005601 term browser browse the term
Definition:A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.



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classical-complement-pathway C3/C5 convertase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2 complement C2 located_in ISO (PMID:6906228) RGD PMID:6906228 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G C4a complement C4A located_in ISO (PMID:6906228) RGD PMID:6906228 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
JBrowse link
G C4b complement C4B (Chido blood group) located_in ISO (PMID:6906228) RGD PMID:6906228 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Cfb complement factor B part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19187
    protein-containing complex 5925
      classical-complement-pathway C3/C5 convertase complex 4
Path 2
Term Annotations click to browse term
  cellular_component 19187
    cellular anatomical entity 18928
      extracellular region 2359
        extracellular space 1730
          classical-complement-pathway C3/C5 convertase complex 4
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