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ONTOLOGY REPORT - ANNOTATIONS

Term:classical-complement-pathway C3/C5 convertase complex
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Accession:GO:0005601 term browser browse the term
Definition:A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.


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classical-complement-pathway C3/C5 convertase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2 complement C2 part_of ISO (PMID:12878586), (PMID:14561755), (PMID:18204047), (PMID:27252379), (PMID:3874204), (PMID:6611150), (PMID:6906228) RGD PMID:3874204 PMID:6611150 PMID:6906228 PMID:12878586 PMID:14561755 More... NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G C3 complement C3 part_of ISS
ISO 		GO_REF:0000024
(PMID:12878586), (PMID:18204047)
(PMID:3874204), (PMID:6611150), (PMID:6906228) 		UniProt
RGD		 PMID:3874204 PMID:6611150 PMID:6906228 PMID:12878586 PMID:18204047 GO_REF:0000024 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G C4a complement C4A (Rodgers blood group) part_of ISO (PMID:14561755), (PMID:27252379)
(PMID:12878586), (PMID:18204047) 		RGD PMID:12878586 PMID:14561755 PMID:18204047 PMID:27252379 NCBI chr20:4,010,306...4,024,707 JBrowse link
G C4b complement C4B part_of ISO (PMID:14561755), (PMID:27252379)
(PMID:12878586), (PMID:18204047) 		RGD PMID:12878586 PMID:14561755 PMID:18204047 PMID:27252379 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19485
    cellular anatomical structure 19353
      extracellular space 1617
        classical-complement-pathway C3/C5 convertase complex 4
Path 2
Term Annotations click to browse term
  cellular_component 19485
    cellular anatomical structure 19353
      extracellular region 2285
        extracellular space 1617
          classical-complement-pathway C3/C5 convertase complex 4
paths to the root