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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane attack complex
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Accession:GO:0005579 term browser browse the term
Definition:A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
Synonyms:exact_synonym: MAC;   TCC;   terminal complement complex
 narrow_synonym: membrane attack complex protein alphaM chain;   membrane attack complex protein beta2 chain
 xref: Wikipedia:Complement_membrane_attack_complex

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membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C5 complement C5 part_of IEA
ISO		 GO_REF:0000107
(PMID:22832194)		 Ensembl
RGD		 PMID:22832194 GO_REF:0000107 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080 		JBrowse link
G C6 complement C6 part_of ISO
IEA		 (PMID:22832194)
GO_REF:0000107		 RGD
Ensembl		 PMID:22832194 GO_REF:0000107 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797 		JBrowse link
G C7 complement C7 part_of ISO (PMID:22832194) RGD PMID:22832194 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729 		JBrowse link
G C8a complement C8 alpha chain part_of ISO (PMID:12413696), (PMID:22832194) RGD PMID:12413696 PMID:22832194 NCBI chr 5:124,348,536...124,403,117
Ensembl chr 5:124,348,461...124,403,195 		JBrowse link
G C8b complement C8 beta chain part_of ISO (PMID:22832194) RGD PMID:22832194 NCBI chr 5:124,298,269...124,338,055
Ensembl chr 5:124,300,477...124,338,053 		JBrowse link
G C8g complement C8 gamma chain part_of IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:2,724,616...2,727,616
Ensembl chr 3:2,724,616...2,727,616 		JBrowse link
G C9 complement C9 part_of ISO
IEA		 (PMID:22832194), (PMID:26841934)
GO_REF:0000107		 RGD
Ensembl		 PMID:22832194 PMID:26841934 GO_REF:0000107 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20126
    protein-containing complex 6038
      membrane protein complex 1243
        pore complex 36
          membrane attack complex 7
Path 2
Term Annotations click to browse term
  cellular_component 20126
    cellular anatomical entity 19825
      membrane 10001
        intrinsic component of membrane 6769
          integral component of membrane 6627
            integral component of plasma membrane 1344
              membrane attack complex 7
paths to the root