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Term:phosphatidylinositol-3,4,5-trisphosphate binding
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Accession:GO:0005547 term browser browse the term
Definition:Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
Synonyms:exact_synonym: PIP3 binding

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phosphatidylinositol-3,4,5-trisphosphate binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adap1 ArfGAP with dual PH domains 1 ISO RGD PMID:9748531 RGD:632412 NCBI chrNW_004955460:8,635,463...8,674,455 JBrowse link
G Adap2 ArfGAP with dual PH domains 2 ISO (PMID:14690521)
PMID:12018390, PMID:14690521 RGD:1299471 NCBI chrNW_004955481:7,068,217...7,094,946 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:19203586) UniProtKB PMID:19203586 NCBI chrNW_004955538:3,208,711...3,224,386 JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO (PMID:11804589) UniProtKB PMID:11804589 NCBI chrNW_004955414:18,667,108...18,726,259 JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 ISO (PMID:11804589) UniProtKB PMID:11804589 NCBI chrNW_004955443:10,537,763...10,719,329 JBrowse link
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 ISO (PMID:11804589) UniProtKB PMID:11804589 NCBI chrNW_004955415:12,098,009...12,121,722 JBrowse link
G Arhgap9 Rho GTPase activating protein 9 ISO (PMID:17339315) UniProtKB PMID:17339315 NCBI chrNW_004955458:5,193,708...5,201,625 JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO (MGI:MGI:5532922|PMID:10734117) FlyBase PMID:10734117 MGI:MGI:5532922 NCBI chrNW_004955461:4,813,228...5,083,548 JBrowse link
G Btk Bruton tyrosine kinase ISO (PMID:17823121) UniProtKB PMID:17823121 NCBI chrNW_004955503:7,483,819...7,515,085 JBrowse link
G Commd1 copper metabolism domain containing 1 ISO (PMID:18940794) UniProtKB PMID:18940794 NCBI chrNW_004955424:21,962,837...22,067,745 JBrowse link
G Cyth3 cytohesin 3 ISO (MGI:MGI:1913269|PMID:11001876), (MGI:MGI:86705|PMID:9072969)
(PMID:23940353), (PMID:9742223)
PMID:9072969, PMID:9742223, PMID:11001876, PMID:23940353 MGI:MGI:1913269, MGI:MGI:86705 NCBI chrNW_004955460:13,439,634...13,492,767 JBrowse link
G Dapp1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 ISO (PMID:11001876) UniProtKB PMID:11001876 NCBI chrNW_004955496:7,813,540...7,855,754 JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO (PMID:29887380) UniProt PMID:29887380 NCBI chrNW_004955414:18,343,832...18,597,675 JBrowse link
G Fermt2 fermitin family member 2 ISO (PMID:21325030), (PMID:22030399) UniProtKB PMID:21325030, PMID:22030399 NCBI chrNW_004955409:10,285,780...10,327,286 JBrowse link
G Gab2 GRB2 associated binding protein 2 ISO (MGI:MGI:3768863|PMID:16456001) UniProtKB PMID:16456001 MGI:MGI:3768863 NCBI chrNW_004955414:13,640,713...13,754,401 JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 ISO (PMID:22573891) UniProtKB PMID:22573891 NCBI chrNW_004955485:8,006,161...8,126,074 JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:22948144 RGD:9686140 NCBI chrNW_004955446:17,146,915...17,457,843 JBrowse link
G Hip1r huntingtin interacting protein 1 related ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004955482:5,885,807...5,896,386 JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chrNW_004955414:19,146,304...19,163,923 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO (PMID:22493426) UniProtKB PMID:22493426 NCBI chrNW_004955416:14,558,628...14,652,031 JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 ISO (PMID:22493426) UniProtKB PMID:22493426 NCBI chrNW_004955425:24,167,985...24,384,912 JBrowse link
G Jph2 junctophilin 2 ISO (PMID:24001019) UniProtKB PMID:24001019 NCBI chrNW_004955445:13,117,312...13,190,061 JBrowse link
G Kif16b kinesin family member 16B ISO (PMID:15882625), (PMID:17641687) UniProtKB PMID:15882625, PMID:17641687 NCBI chrNW_004955415:25,449,734...25,740,697 JBrowse link
G Mapkap1 MAPK associated protein 1 ISO (PMID:17303383) UniProtKB PMID:17303383 NCBI chrNW_004955419:2,656,662...2,887,505 JBrowse link
G Myo1b myosin IB ISO PMID:20610386 UniProt PMID:20610386 RGD:8554686 NCBI chrNW_004955403:7,826,058...7,966,457 JBrowse link
G Myo1g myosin IG ISO (MGI:MGI:5586792|PMID:23038771) UniProtKB PMID:23038771 MGI:MGI:5586792 NCBI chrNW_004955456:7,289,097...7,300,551 JBrowse link
G Npm1 nucleophosmin 1 ISO RGD PMID:15893727 RGD:1600871 NCBI chrNW_004955408:24,151,070...24,218,783 JBrowse link
G Nrgn neurogranin ISO RGD PMID:8995284 RGD:9835428 NCBI chrNW_004955412:25,809,512...25,818,237 JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (PMID:28826662) UniProt PMID:28826662 NCBI chrNW_004955581:148,571...265,062 JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO (PMID:18288188) UniProtKB PMID:18288188 NCBI chrNW_004955475:11,062,258...11,112,252 JBrowse link
G Pard3 par-3 family cell polarity regulator ISO PMID:18082612 UniProt PMID:18082612 RGD:8553352 NCBI chrNW_004955462:2,930,171...3,457,358 JBrowse link
G Phlda3 pleckstrin homology like domain family A member 3 ISO (PMID:19203586) UniProtKB PMID:19203586 NCBI chrNW_004955406:37,579,006...37,582,230 JBrowse link
G Pirt phosphoinositide interacting regulator of transient receptor potential channels ISO (MGI:MGI:3834285|PMID:18455988) MGI PMID:18455988 MGI:MGI:3834285 NCBI chrNW_004955467:6,375,992...6,391,770 JBrowse link
G Pla2g4e phospholipase A2 group IVE ISO (MGI:MGI:6414707|PMID:24413173) UniProt PMID:24413173 MGI:MGI:6414707 NCBI chrNW_004955416:8,765,620...8,826,184 JBrowse link
G Plekhb2 pleckstrin homology domain containing B2 ISO (PMID:11001876) GO_Central PMID:11001876 NCBI chrNW_004955459:594,794...661,152 JBrowse link
G Racgap1 Rac GTPase activating protein 1 ISO (PMID:23235882) UniProtKB PMID:23235882 NCBI chrNW_004955547:584,885...615,883 JBrowse link
G Rag2 recombination activating 2 ISO (MGI:MGI:4441271|PMID:15964836) UniProtKB PMID:15964836 MGI:MGI:4441271 NCBI chrNW_004955422:9,867,307...9,869,732 JBrowse link
G Washc2c WASH complex subunit 2C ISO (PMID:20498093) UniProtKB PMID:20498093 NCBI chrNW_004955546:2,718,758...2,764,277 JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 ISO (PMID:11804589) UniProtKB PMID:11804589 NCBI chrNW_004955523:2,334,175...2,388,612 JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO (PMID:11433298) UniProtKB PMID:11433298 NCBI chrNW_004955418:29,353,276...29,403,336 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 13781
    binding 13027
      lipid binding 504
        phospholipid binding 328
          phosphatidylinositol binding 200
            phosphatidylinositol phosphate binding 150
              phosphatidylinositol-3,4,5-trisphosphate binding 40
Path 2
Term Annotations click to browse term
  molecular_function 13781
    binding 13027
      ion binding 1602
        anion binding 1110
          phospholipid binding 328
            phosphatidylinositol binding 200
              phosphatidylinositol phosphate binding 150
                phosphatidylinositol-3,4,5-trisphosphate binding 40
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.