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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol-3,4,5-trisphosphate binding
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Accession:GO:0005547 term browser browse the term
Definition:Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
Synonyms:exact_synonym: PIP3 binding


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phosphatidylinositol-3,4,5-trisphosphate binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adap1 ArfGAP with dual PH domains 1 IDA RGD PMID:9748531 RGD:632412 NCBI chr12:17,416,327...17,468,212
Ensembl chr12:17,416,327...17,468,212
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 IDA
ISO
PMID:12018390
(PMID:14690521)
RGD PMID:14690521, PMID:12018390 RGD:1299471 NCBI chr10:67,494,851...67,527,582
Ensembl chr10:67,494,984...67,526,426
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:19203586) RGD PMID:19203586 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Anxa8 annexin A8 ISO (PMID:16638567) RGD PMID:16638567 NCBI chr16:10,417,174...10,432,388
Ensembl chr16:10,417,185...10,432,393
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO (PMID:11804589) RGD PMID:11804589 NCBI chr 1:166,459,062...166,525,200
Ensembl chr 1:166,478,005...166,525,255
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 ISO (PMID:11804589) RGD PMID:11804589 NCBI chr14:48,726,033...48,922,809
Ensembl chr14:48,726,045...48,922,983
JBrowse link
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 ISO (PMID:11804589) RGD PMID:11804589 NCBI chr18:31,112,083...31,138,142
Ensembl chr18:31,112,623...31,136,200
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 ISO (PMID:17339315) RGD PMID:17339315 NCBI chr 7:70,612,650...70,620,900
Ensembl chr 7:70,612,103...70,620,890
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO
IEA
(MGI:MGI:5532922|PMID:10734117)
GO_REF:0000107
RGD
Ensembl
PMID:10734117 GO_REF:0000107, MGI:MGI:5532922 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
JBrowse link
G Btk Bruton tyrosine kinase ISO (PMID:17823121) RGD PMID:17823121 NCBI chr  X:105,360,922...105,390,580
Ensembl chr  X:105,360,922...105,390,580
JBrowse link
G Commd1 copper metabolism domain containing 1 ISO (PMID:18940794) RGD PMID:18940794 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Cyth3 cytohesin 3 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:1913269|PMID:11001876), (MGI:MGI:86705|PMID:9072969)
(PMID:23940353), (PMID:9742223)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9072969, PMID:9742223, PMID:11001876, PMID:23940353 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1913269, MGI:MGI:86705 NCBI chr12:12,877,559...12,907,771
Ensembl chr12:12,877,559...12,945,192
JBrowse link
G Dapp1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 ISO (PMID:11001876) RGD PMID:11001876 NCBI chr 2:243,175,346...243,224,883
Ensembl chr 2:243,175,346...243,224,883
JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO (PMID:29887380) RGD PMID:29887380 NCBI chr 1:166,140,025...166,395,915
Ensembl chr 1:166,125,474...166,395,915
JBrowse link
G Fermt2 fermitin family member 2 ISO (PMID:21325030), (PMID:22030399) RGD PMID:21325030, PMID:22030399 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408
JBrowse link
G Gab2 GRB2-associated binding protein 2 ISO
ISS
(MGI:MGI:3768863|PMID:16456001)
GO_REF:0000024
RGD
UniProt
PMID:16456001 GO_REF:0000024, MGI:MGI:3768863 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 ISO (PMID:22573891) RGD PMID:22573891 NCBI chr 1:265,904,616...266,033,107
Ensembl chr 1:265,904,566...266,033,156
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IDA RGD PMID:22948144 RGD:9686140 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hip1r huntingtin interacting protein 1 related ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IDA RGD PMID:12933696 RGD:1626126 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO (PMID:22493426) RGD PMID:22493426 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 ISO (PMID:22493426) RGD PMID:22493426 NCBI chr 2:26,161,628...26,439,067
Ensembl chr 2:26,167,199...26,438,790
JBrowse link
G Jph2 junctophilin 2 ISO
ISS
(PMID:24001019)
GO_REF:0000024
RGD
UniProt
PMID:24001019 GO_REF:0000024 NCBI chr 3:159,709,998...159,776,536
Ensembl chr 3:159,712,325...159,775,643
JBrowse link
G Kif16b kinesin family member 16B ISO (PMID:15882625), (PMID:17641687) RGD PMID:15882625, PMID:17641687 NCBI chr 3:136,596,621...136,936,809
Ensembl chr 3:136,657,480...136,936,674
JBrowse link
G Mapkap1 MAPK associated protein 1 ISO (PMID:17303383) RGD PMID:17303383 NCBI chr 3:13,484,952...13,701,772
Ensembl chr 3:13,484,838...13,701,757
JBrowse link
G Myo10 myosin X ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:77,868,398...78,072,443
Ensembl chr 2:77,868,412...78,071,309
JBrowse link
G Myo1b myosin Ib IDA PMID:20610386 UniProt PMID:20610386 RGD:8554686 NCBI chr 9:54,706,005...54,766,054
Ensembl chr 9:54,558,202...54,766,054
JBrowse link
G Myo1g myosin IG ISO (MGI:MGI:5586792|PMID:23038771) RGD PMID:23038771 MGI:MGI:5586792 NCBI chr14:86,781,243...86,796,393
Ensembl chr14:86,781,202...86,796,378
JBrowse link
G Npm1 nucleophosmin 1 IPI RGD PMID:15893727 RGD:1600871 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nrgn neurogranin IDA RGD PMID:8995284 RGD:9835428 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (PMID:28826662) RGD PMID:28826662 NCBI chr10:45,353,185...45,483,570
Ensembl chr10:45,338,009...45,481,008
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:18288188)
Ensembl
UniProt
RGD
PMID:18288188 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
G Pard3 par-3 family cell polarity regulator IDA PMID:18082612 UniProt PMID:18082612 RGD:8553352 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 ISO
ISS
(PMID:19203586)
GO_REF:0000024
RGD
UniProt
PMID:19203586 GO_REF:0000024 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pirt phosphoinositide-interacting regulator of transient receptor potential channels ISO (MGI:MGI:3834285|PMID:18455988) RGD PMID:18455988 MGI:MGI:3834285 NCBI chr10:53,466,870...53,485,096
Ensembl chr10:53,466,870...53,481,770
JBrowse link
G Pla2g4e phospholipase A2, group IVE ISO
IEA
(MGI:MGI:6414707|PMID:24413173)
GO_REF:0000107
RGD
Ensembl
PMID:24413173 GO_REF:0000107, MGI:MGI:6414707 NCBI chr 3:111,952,396...112,018,470
Ensembl chr 3:111,952,348...111,994,337
JBrowse link
G Plekhb2 pleckstrin homology domain containing B2 ISO (PMID:11001876) RGD PMID:11001876 NCBI chr 9:41,348,447...41,381,096
Ensembl chr 9:41,348,449...41,381,101
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 ISO (PMID:23235882) RGD PMID:23235882 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rag2 recombination activating 2 ISO (MGI:MGI:4441271|PMID:15964836) RGD PMID:15964836 MGI:MGI:4441271 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
JBrowse link
G Rs1 retinoschisin 1 ISO (MGI:MGI:3717560|PMID:17325137) RGD PMID:17325137 MGI:MGI:3717560 NCBI chr  X:35,749,957...35,777,243
Ensembl chr  X:35,749,957...35,777,243
JBrowse link
G Washc2c WASH complex subunit 2C ISO (PMID:20498093) RGD PMID:20498093 NCBI chr 4:148,139,512...148,197,363
Ensembl chr 4:148,139,528...148,197,365
JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 ISO (PMID:11804589) RGD PMID:11804589 NCBI chr 6:107,031,411...107,080,590
Ensembl chr 6:107,031,412...107,080,524
JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO (PMID:11433298) RGD PMID:11433298 NCBI chr 2:22,060,879...22,105,822
Ensembl chr 2:22,062,050...22,105,710
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20457
    binding 17201
      lipid binding 806
        phospholipid binding 474
          phosphatidylinositol binding 274
            phosphatidylinositol phosphate binding 188
              phosphatidylinositol-3,4,5-trisphosphate binding 43
Path 2
Term Annotations click to browse term
  molecular_function 20457
    binding 17201
      ion binding 5660
        anion binding 2895
          phospholipid binding 474
            phosphatidylinositol binding 274
              phosphatidylinositol phosphate binding 188
                phosphatidylinositol-3,4,5-trisphosphate binding 43
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.