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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol-4,5-bisphosphate binding
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Accession:GO:0005546 term browser browse the term
Definition:Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
Synonyms:exact_synonym: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding;   PtdIns(4,5)P2 binding
 broad_synonym: PIP2 binding


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phosphatidylinositol-4,5-bisphosphate binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:16,186,844...16,248,394
Ensembl chrNW_004936484:16,186,642...16,248,400
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 enables ISO PMID:12018390 UniProt PMID:12018390 RGD:1299471 NCBI chrNW_004936538:2,767,489...2,790,080
Ensembl chrNW_004936538:2,765,596...2,790,055
JBrowse link
G Alox15 arachidonate 15-lipoxygenase enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:3,232,183...3,241,307
Ensembl chrNW_004936677:3,232,183...3,241,253
JBrowse link
G Amer1 APC membrane recruitment protein 1 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936635:3,465,473...3,482,311
Ensembl chrNW_004936635:3,478,598...3,482,008
JBrowse link
G Amer2 APC membrane recruitment protein 2 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936688:1,136,060...1,139,078
Ensembl chrNW_004936688:1,136,224...1,138,275
JBrowse link
G Amer3 APC membrane recruitment protein 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936469:41,234,187...41,244,603
Ensembl chrNW_004936469:41,238,646...41,244,623
JBrowse link
G Anxa2 annexin A2 enables ISO
IEA
RGD
TreeGrafter
Ensembl
PMID:14734570 GO_REF:0000107 GO_REF:0000118 RGD:1578381 NCBI chrNW_004936471:21,274,112...21,329,286
Ensembl chrNW_004936471:21,274,027...21,329,503
JBrowse link
G Anxa9 annexin A9 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:1,208,536...1,218,438
Ensembl chrNW_004936580:1,208,120...1,220,173
JBrowse link
G Apba1 amyloid beta precursor protein binding family A member 1 ISO RGD PMID:9395480 RGD:727250 NCBI chrNW_004936503:5,699,580...5,770,920
Ensembl chrNW_004936503:5,699,558...5,771,030
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 enables
NOT|enables
IEA
ISO
(MGI:5758807|PMID:12771146) Ensembl
MGI
PMID:12771146 GO_REF:0000107 MGI:5758807 NCBI chrNW_004936470:18,340,120...18,640,396
Ensembl chrNW_004936470:18,339,616...18,640,624
JBrowse link
G Avil advillin enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936646:1,930,447...1,952,069
Ensembl chrNW_004936646:1,930,656...1,948,991
JBrowse link
G Cadps calcium dependent secretion activator enables ISO PMID:9525942 WB PMID:9525942 RGD:10047153 NCBI chrNW_004936637:3,543,615...4,023,710
Ensembl chrNW_004936637:3,545,211...4,022,630
JBrowse link
G Capg capping actin protein, gelsolin like enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936712:1,793,666...1,803,621
Ensembl chrNW_004936712:1,793,480...1,806,602
JBrowse link
G Cgas cyclic GMP-AMP synthase enables ISO (PMID:30827685) UniProt PMID:30827685 NCBI chrNW_004936859:797,469...807,036 JBrowse link
G Chmp3 charged multivesicular body protein 3 ISO RGD PMID:12878588 RGD:1299526 NCBI chrNW_004936712:1,023,994...1,044,727
Ensembl chrNW_004936712:1,023,989...1,044,728
JBrowse link
G Commd1 copper metabolism domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:7,247,160...7,421,039
Ensembl chrNW_004936491:7,247,140...7,420,921
JBrowse link
G Dab2 DAB adaptor protein 2 enables ISO (MGI:2675568|PMID:12826668) UniProt PMID:12826668 MGI:2675568 NCBI chrNW_004936518:2,915,819...2,936,474
Ensembl chrNW_004936518:2,915,764...2,937,875
JBrowse link
G Dnm1 dynamin 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:15,767,897...15,797,722
Ensembl chrNW_004936487:15,767,897...15,801,211
JBrowse link
G Dnm2 dynamin 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:957,408...1,046,393
Ensembl chrNW_004936659:957,392...1,049,188
JBrowse link
G Exoc1 exocyst complex component 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936482:18,148,672...18,199,481
Ensembl chrNW_004936482:18,148,674...18,199,490
JBrowse link
G Exoc7 exocyst complex component 7 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936594:1,244,545...1,264,211
Ensembl chrNW_004936594:1,244,483...1,264,288
JBrowse link
G Fcho2 FCH and mu domain containing endocytic adaptor 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:3,455,172...3,565,507
Ensembl chrNW_004936549:3,455,172...3,565,558
JBrowse link
G Flii FLII actin remodeling protein enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936741:1,784,802...1,796,176
Ensembl chrNW_004936741:1,783,589...1,796,168
JBrowse link
G Frmpd4 FERM and PDZ domain containing 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:1,923,328...2,469,067
Ensembl chrNW_004936470:1,923,835...2,470,564
JBrowse link
G Fzd7 frizzled class receptor 7 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936726:1,256,684...1,275,324
Ensembl chrNW_004936726:1,256,678...1,275,467
JBrowse link
G Gramd2a GRAM domain containing 2A enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:31,550,506...31,588,377
Ensembl chrNW_004936471:31,550,406...31,587,981
JBrowse link
G Gsdma gasdermin A enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936490:15,105,030...15,115,007
Ensembl chrNW_004936490:15,105,030...15,114,599
JBrowse link
G Gsdmc gasdermin C enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:18,840,455...18,856,022
Ensembl chrNW_004936470:18,843,579...18,855,639
JBrowse link
G Gsdmd gasdermin D enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:8,567,085...8,571,448
Ensembl chrNW_004936470:8,567,091...8,571,467
JBrowse link
G Gsdme gasdermin E enables ISO (PMID:28459430) UniProt PMID:28459430 NCBI chrNW_004936478:1,655,487...1,720,996 JBrowse link
G Gsn gelsolin enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841
JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:22948144 RGD:9686140 NCBI chrNW_004936480:17,051,902...17,416,335
Ensembl chrNW_004936480:17,051,898...17,413,657
JBrowse link
G Hip1 huntingtin interacting protein 1 NOT|enables ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004936543:2,496,301...2,569,019
Ensembl chrNW_004936543:2,522,154...2,565,376
JBrowse link
G Hip1r huntingtin interacting protein 1 related enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:1,778,862...1,804,071
Ensembl chrNW_004936558:1,778,888...1,791,610
JBrowse link
G Jph2 junctophilin 2 enables ISO (PMID:24001019) UniProt PMID:24001019 NCBI chrNW_004936530:2,570,365...2,606,743 JBrowse link
G Kcnj1 potassium inwardly rectifying channel subfamily J member 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936572:3,396,329...3,425,848
Ensembl chrNW_004936572:3,421,557...3,425,276
JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936655:3,447,026...3,459,569
Ensembl chrNW_004936655:3,447,321...3,458,312
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:707,122...994,206
Ensembl chrNW_004936794:707,119...994,778
JBrowse link
G Krit1 KRIT1 ankyrin repeat containing enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:2,088,606...2,128,579
Ensembl chrNW_004936621:2,088,802...2,128,657
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:10,196,228...10,219,137
Ensembl chrNW_004936474:10,196,211...10,221,777
JBrowse link
G LOC101962737 obscurin enables ISO (PMID:28826662) UniProt PMID:28826662 NCBI chrNW_004936864:619...33,574 JBrowse link
G LOC101967251 profilin-2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,992,508...1,993,271 JBrowse link
G Mapkap1 MAPK associated protein 1 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936487:13,511,632...13,743,022
Ensembl chrNW_004936487:13,510,592...13,743,069
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:1,607,480...1,672,591
Ensembl chrNW_004936650:1,605,487...1,667,297
JBrowse link
G Mtss2 MTSS I-BAR domain containing 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:22,948,608...22,967,489
Ensembl chrNW_004936475:22,950,793...22,967,467
JBrowse link
G Myo1b myosin IB enables ISO PMID:20610386 UniProt PMID:20610386 RGD:8554686 NCBI chrNW_004936506:6,832,132...7,004,262
Ensembl chrNW_004936506:6,832,670...7,004,273
JBrowse link
G Myo1g myosin IG enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:19,788,032...19,802,546
Ensembl chrNW_004936478:19,788,031...19,802,501
JBrowse link
G Osbpl2 oxysterol binding protein like 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:9,882,066...9,916,378
Ensembl chrNW_004936514:9,891,258...9,915,416
JBrowse link
G Pard3 par-3 family cell polarity regulator enables ISO PMID:18082612 UniProt PMID:18082612 RGD:8553352 NCBI chrNW_004936574:2,472,064...3,013,590
Ensembl chrNW_004936574:2,473,675...3,013,582
JBrowse link
G Pfn1 profilin 1 enables ISO
IEA
RGD
Ensembl
PMID:16741017 GO_REF:0000107 RGD:2324852 NCBI chrNW_004936677:2,762,971...2,766,038
Ensembl chrNW_004936677:2,762,971...2,766,149
JBrowse link
G Pfn2 profilin 2 enables IEA Ensembl GO_REF:0000107
G Phlda3 pleckstrin homology like domain family A member 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:2,981,632...2,984,906
Ensembl chrNW_004936567:2,981,602...2,984,903
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
JBrowse link
G Pla2g4e phospholipase A2 group IVE enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:5,300,932...5,370,150
Ensembl chrNW_004936471:5,302,688...5,370,182
JBrowse link
G Plcb1 phospholipase C beta 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761
JBrowse link
G Plcd1 phospholipase C delta 1 enables ISO
IEA
RGD
Ensembl
PMID:9804818 GO_REF:0000107 RGD:2301015 NCBI chrNW_004936473:27,364,404...27,387,337
Ensembl chrNW_004936473:27,364,389...27,387,412
JBrowse link
G Plcz1 phospholipase C zeta 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936548:7,522,902...7,573,540
Ensembl chrNW_004936548:7,522,926...7,573,540
JBrowse link
G Plekha4 pleckstrin homology domain containing A4 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936664:2,890,279...2,908,423
Ensembl chrNW_004936664:2,890,463...2,907,871
JBrowse link
G Rab35 RAB35, member RAS oncogene family enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:795,477...812,187
Ensembl chrNW_004936668:800,854...810,128
JBrowse link
G Rag2 recombination activating 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936533:1,801,207...1,807,431
Ensembl chrNW_004936533:1,801,391...1,807,431
JBrowse link
G Rph3a rabphilin 3A ISO RGD PMID:18945677 RGD:2314874 NCBI chrNW_004936668:2,827,574...2,911,955
Ensembl chrNW_004936668:2,857,732...2,911,517
JBrowse link
G Rs1 retinoschisin 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936844:284,938...314,524
Ensembl chrNW_004936844:284,141...314,545
JBrowse link
G Scin scinderin enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936795:418,874...495,990
Ensembl chrNW_004936795:418,436...495,936
JBrowse link
G Sdcbp syndecan binding protein enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:14,331,971...14,347,123
Ensembl chrNW_004936496:14,331,662...14,347,197
JBrowse link
G Sdcbp2 syndecan binding protein 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:17,336,209...17,356,896
Ensembl chrNW_004936485:17,336,417...17,357,027
JBrowse link
G Sestd1 SEC14 and spectrin domain containing 1 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936509:8,225,252...8,303,257
Ensembl chrNW_004936509:8,225,245...8,303,279
JBrowse link
G Sh3pxd2a SH3 and PX domains 2A enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936600:2,343,709...2,513,497
Ensembl chrNW_004936600:2,343,658...2,509,612
JBrowse link
G Snap91 synaptosome associated protein 91 enables ISO
IEA
RGD
TreeGrafter
PMID:9188501 GO_REF:0000118 RGD:13506241 NCBI chrNW_004936510:7,222,200...7,345,138
Ensembl chrNW_004936510:7,223,757...7,343,742
JBrowse link
G Snx18 sorting nexin 18 enables ISO (PMID:23878278) FlyBase PMID:23878278 NCBI chrNW_004936480:13,108,510...13,137,550 JBrowse link
G Snx21 sorting nexin family member 21 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:7,180,533...7,188,201
Ensembl chrNW_004936514:7,180,851...7,186,146
JBrowse link
G Stxbp6 syntaxin binding protein 6 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936494:250,131...494,599
Ensembl chrNW_004936494:250,126...438,956
JBrowse link
G Svil supervillin enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936613:4,391,928...4,540,125
Ensembl chrNW_004936613:4,404,711...4,542,890
JBrowse link
G Syt1 synaptotagmin 1 enables ISO PMID:12860971 RGD
ParkinsonsUK-UCL
PMID:12860971 PMID:22447935 RGD:11079189 RGD:7205653 NCBI chrNW_004936698:65,210...575,538
Ensembl chrNW_004936698:377,179...575,802
JBrowse link
G Syt10 synaptotagmin 10 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:2,940,607...2,995,178
Ensembl chrNW_004936607:2,940,466...2,994,344
JBrowse link
G Syt3 synaptotagmin 3 enables ISO PMID:12860971 ParkinsonsUK-UCL PMID:12860971 RGD:11079189 NCBI chrNW_004936889:404,534...411,885 JBrowse link
G Syt5 synaptotagmin 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936886:451,400...457,093
Ensembl chrNW_004936886:449,194...457,088
JBrowse link
G Syt7 synaptotagmin 7 enables ISO (MGI:5645834|PMID:25860611), (MGI:5780544|PMID:12860971) ParkinsonsUK-UCL PMID:12860971 PMID:25860611 MGI:5645834 MGI:5780544 NCBI chrNW_004936581:1,516,199...1,557,992
Ensembl chrNW_004936581:1,512,855...1,559,679
JBrowse link
G Syt9 synaptotagmin 9 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936841:542,211...706,272
Ensembl chrNW_004936841:542,417...708,797
JBrowse link
G Sytl2 synaptotagmin like 2 enables ISO (PMID:17182843) UniProt PMID:17182843 NCBI chrNW_004936498:13,577,839...13,681,782
Ensembl chrNW_004936498:13,577,795...13,681,808
JBrowse link
G Tirap TIR domain containing adaptor protein enables ISO (MGI:4948831|PMID:16751103) BHF-UCL PMID:16751103 MGI:4948831 NCBI chrNW_004936572:5,926,193...5,938,621
Ensembl chrNW_004936572:5,924,158...5,938,658
JBrowse link
G Ttpa alpha tocopherol transfer protein enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:10,409,948...10,466,722
Ensembl chrNW_004936496:10,454,605...10,465,301
JBrowse link
G Tulp1 TUB like protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:23,744,707...23,757,002
Ensembl chrNW_004936476:23,744,757...23,756,565
JBrowse link
G Twf1 twinfilin actin binding protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:2,280,266...2,293,101
Ensembl chrNW_004936512:2,280,064...2,293,117
JBrowse link
G Vil1 villin 1 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936569:914,511...938,481
Ensembl chrNW_004936569:914,512...938,608
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17084
    binding 15355
      small molecule binding 5005
        ion binding 4776
          anion binding 2197
            phosphatidylinositol-4,5-bisphosphate binding 84
Path 2
Term Annotations click to browse term
  molecular_function 17084
    binding 15355
      lipid binding 763
        phospholipid binding 468
          phosphatidylinositol binding 277
            phosphatidylinositol phosphate binding 185
              phosphatidylinositol bisphosphate binding 109
                phosphatidylinositol-4,5-bisphosphate binding 84
paths to the root