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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol-4,5-bisphosphate binding
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Accession:GO:0005546 term browser browse the term
Definition:Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
Synonyms:exact_synonym: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding;   PtdIns(4,5)P2 binding
 broad_synonym: PIP2 binding


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phosphatidylinositol-4,5-bisphosphate binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07051501.1 RGD:13792537
G Actn2 actinin alpha 2 JBrowse link 17 66,304,530 66,397,647 RGD:1624291
RGD:1600115
G Adap2 ArfGAP with dual PH domains 2 JBrowse link 10 67,494,851 67,527,582 RGD:1299471
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:1624291
RGD:1600115
G Amer1 APC membrane recruitment protein 1 JBrowse link X 64,686,620 64,702,504 RGD:1624291
RGD:13792537
G Amer2 APC membrane recruitment protein 2 JBrowse link 15 40,663,183 40,667,705 RGD:1624291
RGD:13792537
G Amer3 APC membrane recruitment protein 3 JBrowse link 9 41,089,417 41,101,108 RGD:13792537
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:1578381
RGD:13792537
RGD:1624291
G Anxa8 annexin A8 JBrowse link 16 10,417,174 10,432,388 RGD:1624291
G Anxa9 annexin A9 JBrowse link 2 196,470,318 196,481,568 RGD:13792537
G Apba1 amyloid beta precursor protein binding family A member 1 JBrowse link 1 241,594,565 241,796,512 RGD:727250
G Apba2 amyloid beta precursor protein binding family A member 2 JBrowse link 1 125,367,273 125,547,741 RGD:727250
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 JBrowse link 7 104,670,076 104,951,090 RGD:1600115
RGD:1624291
G Cadps calcium dependent secretion activator JBrowse link 15 15,275,489 15,690,575 RGD:10047153
RGD:11535098
G Cgas cyclic GMP-AMP synthase JBrowse link 8 85,789,515 85,804,008 RGD:1624291
RGD:1600115
G Chmp3 charged multivesicular body protein 3 JBrowse link 4 99,449,213 99,496,156 RGD:1299526
G Commd1 copper metabolism domain containing 1 JBrowse link 14 107,664,321 107,759,974 RGD:1624291
RGD:1600115
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
G Exoc1 exocyst complex component 1 JBrowse link 14 34,132,210 34,192,296 RGD:13792537
G Exoc1l exocyst complex component 1 like JBrowse link 14 34,192,155 34,219,497 RGD:13792537
G Fcho2 FCH and mu domain containing endocytic adaptor 2 JBrowse link 2 28,927,918 29,029,271 RGD:1624291
RGD:1600115
G Frmpd4 FERM and PDZ domain containing 4 JBrowse link X 27,231,648 28,206,890 RGD:1624291
RGD:13792537
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:1624291
RGD:1600115
G Gramd2a GRAM domain containing 2A JBrowse link 8 64,503,058 64,539,149 RGD:1600115
RGD:1624291
G Gsdma gasdermin A JBrowse link 10 86,569,898 86,595,102 RGD:13792537
G Gsdmc gasdermin C JBrowse link 7 104,474,418 104,492,373 RGD:13792537
G Gsdmd gasdermin D JBrowse link 7 116,889,147 116,894,134 RGD:1624291
RGD:13792537
G Gsdme gasdermin E JBrowse link 4 79,934,075 79,999,678 RGD:1624291
RGD:1600115
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 JBrowse link 2 50,099,576 50,499,799 RGD:9686140
G Hip1 huntingtin interacting protein 1 JBrowse link 12 24,180,795 24,315,373 RGD:1624291
G Hip1r huntingtin interacting protein 1 related JBrowse link 12 38,024,517 38,053,184 RGD:1624291
RGD:1600115
G Jph2 junctophilin 2 JBrowse link 3 159,709,998 159,776,536 RGD:1624291
RGD:1600115
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:1624291
RGD:1600115
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 JBrowse link 10 99,429,337 99,442,520 RGD:1624291
RGD:1600115
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 1 216,293,087 216,630,339 RGD:1600115
RGD:1624291
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 4 27,438,609 27,473,150 RGD:1624291
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 JBrowse link 5 152,964,294 152,987,286 RGD:1624291
RGD:1600115
G LOC100909840 profilin-2-like JBrowse link 2 148,044,714 148,050,464 RGD:1600115
G Mapkap1 MAPK associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:1624291
RGD:13792537
G Mark1 microtubule affinity regulating kinase 1 JBrowse link 13 102,808,254 102,942,863 RGD:1624291
RGD:1600115
G Mtss2 MTSS I-BAR domain containing 2 JBrowse link 19 40,904,779 40,925,660 RGD:1624291
RGD:1600115
G Myo1b myosin Ib JBrowse link 9 54,706,005 54,766,054 RGD:8554686
G Myo1g myosin IG JBrowse link 14 86,781,243 86,796,393 RGD:1624291
RGD:1600115
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF JBrowse link 10 45,353,185 45,483,570 RGD:1624291
G Osbpl2 oxysterol binding protein-like 2 JBrowse link 3 175,493,650 175,538,965 RGD:1600115
RGD:1624291
G Pard3 par-3 family cell polarity regulator JBrowse link 19 60,017,746 60,580,628 RGD:8553352
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:2324852
RGD:1624291
G Pfn2 profilin 2 JBrowse link 2 147,953,858 147,959,692 RGD:1600115
RGD:1624291
G Phlda3 pleckstrin homology-like domain, family A, member 3 JBrowse link 13 52,588,917 52,592,002 RGD:1624291
RGD:1600115
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:13210546
RGD:13792537
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G Plcd1 phospholipase C, delta 1 JBrowse link 8 127,753,514 127,782,070 RGD:2301015
RGD:1624291
RGD:1600115
G Plcz1 phospholipase C, zeta 1 JBrowse link 4 174,125,072 174,181,524 RGD:1600115
RGD:1624291
G Plekha4 pleckstrin homology domain containing A4 JBrowse link 1 101,517,702 101,540,802 RGD:1600115
RGD:1624291
G Rab35 RAB35, member RAS oncogene family JBrowse link 12 46,704,274 46,718,404 RGD:1624291
RGD:1600115
G Rag2 recombination activating 2 JBrowse link 3 91,191,837 91,200,134 RGD:1624291
RGD:1600115
G RGD1359449 gasdermin domain containing protein RGD1359449 JBrowse link 7 104,500,564 104,511,236 RGD:13792537
G Rph3a rabphilin 3A JBrowse link 12 41,073,296 41,149,799 RGD:2314874
G Rs1 retinoschisin 1 JBrowse link X 35,749,957 35,777,243 RGD:1624291
RGD:1600115
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
G Sdcbp2 syndecan binding protein 2 JBrowse link 3 147,073,160 147,101,917 RGD:1624291
RGD:1600115
G Sestd1 SEC14 and spectrin domain containing 1 JBrowse link 3 64,037,814 64,134,973 RGD:1624291
RGD:1600115
G Sh3pxd2a SH3 and PX domains 2A JBrowse link 1 267,039,654 267,245,868 RGD:1600115
RGD:1624291
G Snap91 synaptosome associated protein 91 JBrowse link 8 94,447,558 94,564,772 RGD:13506241
RGD:13792537
G Snx18 sorting nexin 18 JBrowse link 2 45,454,782 45,480,798 RGD:1624291
RGD:1600115
G Snx20 sorting nexin 20 JBrowse link 19 19,395,655 19,404,846 RGD:1624291
RGD:1600115
G Snx21 sorting nexin family member 21 JBrowse link 3 161,252,634 161,261,880 RGD:1624291
RGD:1600115
G Stxbp6 syntaxin binding protein 6 JBrowse link 6 65,086,483 65,319,527 RGD:13792537
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:7205653
RGD:11079189
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:1624291
RGD:1600115
G Syt3 synaptotagmin 3 JBrowse link 1 100,379,236 100,407,862 RGD:11079189
G Syt5 synaptotagmin 5 JBrowse link 1 72,859,806 72,867,934 RGD:1624291
RGD:1600115
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:1600115
RGD:1624291
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:1624291
RGD:1600115
G Sytl2 synaptotagmin-like 2 JBrowse link 1
1
154,536,592
156,334,298
154,599,515
156,440,327
RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Ttpa alpha tocopherol transfer protein JBrowse link 5 34,007,926 34,029,315 RGD:1624291
RGD:1600115
G Tulp1 TUB like protein 1 JBrowse link 20 7,931,673 7,943,601 RGD:1624291
RGD:1600115
G Twf1 twinfilin actin-binding protein 1 JBrowse link 7 135,838,647 135,850,542 RGD:1624291
RGD:1600115
G Twf2 twinfilin actin-binding protein 2 JBrowse link 8 114,897,011 114,909,531 RGD:1624291
RGD:1600115
G Vil1 villin 1 JBrowse link 9 81,689,802 81,717,623 RGD:1624291
RGD:1600115
G Washc2c WASH complex subunit 2C JBrowse link 4 148,139,512 148,197,363 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19460
    binding 15841
      lipid binding 747
        phospholipid binding 437
          phosphatidylinositol binding 258
            phosphatidylinositol phosphate binding 171
              phosphatidylinositol bisphosphate binding 114
                phosphatidylinositol-4,5-bisphosphate binding 82
Path 2
Term Annotations click to browse term
  molecular_function 19460
    binding 15841
      ion binding 5414
        anion binding 2832
          phospholipid binding 437
            phosphatidylinositol binding 258
              phosphatidylinositol phosphate binding 171
                phosphatidylinositol bisphosphate binding 114
                  phosphatidylinositol-4,5-bisphosphate binding 82
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.