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ONTOLOGY REPORT - ANNOTATIONS

Term:P-type sodium:potassium-exchanging transporter activity
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Accession:GO:0005391 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
Synonyms:exact_synonym: P-type sodium:potassium-exchanging ATPase activity;   sodium/potassium-exchanging ATPase activity;   sodium/potassium-transporting ATPase activity
 broad_synonym: sodium pump
 related_synonym: Na+,K+-ATPase activity;   Na+/K+-exchanging ATPase activity;   Na,K-activated ATPase activity
 xref: EC:7.2.2.13;   MetaCyc:3.6.3.9-RXN;   RHEA:18353;   Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+";   TC:3.A.3.1.1;   Wikipedia:ATPase\,_Na%2B/K%2B_transporting\,_alpha_1


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P-type sodium:potassium-exchanging transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
(PMID:9774385)		 UniProt
GO_Central
TreeGrafter
RGD		 PMID:9774385 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 enables IDA
ISO
IEA
IBA		 UniProtKB:P05027 (PMID:10636900), (PMID:18052210), (PMID:19542013)
(PMID:18075585), (PMID:19542013)
PMID:17939993
GO_REF:0000107
GO_REF:0000033
(PMID:10360172), (PMID:15485817), (PMID:23229519)		 RGD
Ensembl
GO_Central		 PMID:10360172 PMID:10636900 PMID:15485817 PMID:18052210 PMID:18075585 More... GO_REF:0000033 GO_REF:0000107, RGD:629542, RGD:1581763, RGD:2302992, RGD:10047180, RGD:8554378 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 enables IDA
ISO
IEA
IBA		 UniProtKB:P05026|UniProtKB:P05027 (PMID:10636900), (PMID:12539047), (PMID:18052210), (PMID:18728015), (PMID:20100892), (PMID:23954377)
GO_REF:0000118
GO_REF:0000033		 RGD
TreeGrafter
GO_Central		 PMID:10636900 PMID:12539047 PMID:18052210 PMID:18728015 PMID:20100892 More... GO_REF:0000033 GO_REF:0000118, RGD:2302992 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables NAS
ISO
IEA
IBA
ISS		 PMID:26224839
(PMID:19666602), (PMID:21418141)
GO_REF:0000118
GO_REF:0000033
GO_REF:0000107
(PMID:10636900), (PMID:15260953)
GO_REF:0000024		 RGD
TreeGrafter
GO_Central
Ensembl
UniProt		 PMID:10636900 PMID:15260953 PMID:19666602 PMID:21418141 PMID:26224839 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:11576284 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 enables TAS
ISO
IBA
IEA
IDA		 MGI:4941050 (PMID:21187400), (PMID:23229519)
GO_REF:0000033
GO_REF:0000107
PMID:10555956
UniProtKB:P05026|UniProtKB:P54709 (PMID:16861705)		 RGD
GO_Central
Ensembl		 PMID:16861705 PMID:21187400 PMID:23229519 PMID:12112599 PMID:10555956 GO_REF:0000033 GO_REF:0000107, RGD:728364, RGD:8553802 NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 enables IDA
ISO
IEA		 (PMID:19542013)
GO_REF:0000107		 RGD
Ensembl		 PMID:19542013 PMID:16624992 GO_REF:0000107, RGD:2302992 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 IDA RGD PMID:12562669 RGD:631758 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 IDA
IC
TAS		 RGD PMID:12562669 PMID:16624992 PMID:15327400 PMID:12562669 RGD:631758, RGD:2302992, RGD:2302991, RGD:631758 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598 		JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:85,961,607...85,974,972
Ensembl chr 1:85,961,708...85,974,844 		JBrowse link
G Myh9 myosin, heavy chain 9 enables ISS PMID:2477373 UniProt PMID:2477373 RGD:8554445 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables ISO UniProtKB:A2ASQ1 (MGI:4352602|PMID:19376779) RGD PMID:19376779 MGI:4352602 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    ATP-dependent activity 632
      ATPase-coupled transmembrane transporter activity 118
        ATPase-coupled monoatomic cation transmembrane transporter activity 65
          P-type sodium transporter activity 10
            P-type sodium:potassium-exchanging transporter activity 10
              P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential 1
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        active transmembrane transporter activity 448
          primary active transmembrane transporter activity 153
            ATPase-coupled transmembrane transporter activity 118
              P-type transmembrane transporter activity 30
                P-type ion transporter activity 30
                  P-type sodium transporter activity 10
                    P-type sodium:potassium-exchanging transporter activity 10
                      P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential 1
paths to the root