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ONTOLOGY REPORT - ANNOTATIONS


Term:voltage-gated sodium channel activity
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Accession:GO:0005248 term browser browse the term
Definition:Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms:exact_synonym: voltage-dependent sodium channel activity;   voltage-gated sodium ion channel activity;   voltage-sensitive sodium channel
 xref: reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol"


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voltage-gated sodium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic2 acid sensing ion channel subunit 2 ISO RGD PMID:9368048 RGD:1298619 NCBI chrNW_004936538:938,266...2,011,154 JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO (PMID:22748890) UniProtKB PMID:22748890 NCBI chrNW_004936480:17,051,902...17,416,335 JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 ISO (PMID:22748890) UniProtKB PMID:22748890 NCBI chrNW_004936588:202,101...209,255 JBrowse link
G Hcn3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 ISO (PMID:22748890) UniProtKB PMID:22748890 NCBI chrNW_004936580:4,760,289...4,770,571 JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO (PMID:22748890) UniProtKB PMID:22748890 NCBI chrNW_004936471:32,527,551...32,570,548 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (PMID:11252306)
(PMID:27071085)
BHF-UCL
UniProtKB
PMID:11252306, PMID:27071085 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO (MGI:MGI:3590477|PMID:16029194)
(PMID:9839820)
RGD
MGI
BHF-UCL
PMID:8538791, PMID:9839820, PMID:16029194 MGI:MGI:3590477, RGD:69979 NCBI chrNW_004936473:28,010,123...28,102,124 JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 ISO (MGI:MGI:3590477|PMID:16029194) MGI PMID:16029194 MGI:MGI:3590477 NCBI chrNW_004936473:28,162,528...28,248,474 JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 ISO (MGI:MGI:5796061|PMID:27281198)
(MGI:MGI:3664677|PMID:16921370)
UniProtKB
MGI
RGD
PMID:15664695, PMID:16921370, PMID:17273863, PMID:27281198 MGI:MGI:3664677, MGI:MGI:5796061, RGD:1599536, RGD:2289022 NCBI chrNW_004936469:13,194,769...13,345,979 JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:14622265), (PMID:19808477) BHF-UCL PMID:14622265, PMID:19808477 NCBI chrNW_004936570:1,187,916...1,195,423 JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 ISO (MGI:MGI:2179539|PMID:10827969)
PMID:28029095
PMID:24297919
(PMID:28256214)
UniProt
RGD
UniProtKB
PMID:2442385, PMID:10827969, PMID:15664695, PMID:24297919, PMID:28029095, PMID:28256214 MGI:MGI:2179539, RGD:1299025, RGD:14390052, RGD:1599536, RGD:8554774 NCBI chrNW_004936469:13,872,701...14,019,170 JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO RGD PMID:8521473 RGD:729729 NCBI chrNW_004936542:3,262,161...3,274,545 JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 ISO RGD PMID:15664695 RGD:1599536 NCBI chrNW_004936469:14,072,182...14,180,552 JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 ISO (PMID:12766226), (PMID:30190309)
(MGI:MGI:3623302|PMID:11834499)
UniProt
MGI
PMID:11834499, PMID:12766226, PMID:30190309 MGI:MGI:3623302 NCBI chrNW_004936541:4,541,061...4,570,212 JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 ISO (PMID:12930796)
(MGI:MGI:4462719|PMID:20566860)
UniProtKB
MGI
PMID:12930796, PMID:20566860 MGI:MGI:4462719 NCBI chrNW_004936542:3,236,238...3,252,550 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO (MGI:MGI:3623302|PMID:11834499), (MGI:MGI:5824815|PMID:26187182)
(MGI:MGI:5824815|PMID:26187182)
(PMID:23085483), (PMID:26279430), (PMID:26392562)
(PMID:14500339), (PMID:19074138), (PMID:19808477), (PMID:19943616), (PMID:21895525), (PMID:22514276)
MGI
UniProtKB
BHF-UCL
PMID:11834499, PMID:14500339, PMID:19074138, PMID:19808477, PMID:19943616, PMID:21895525, PMID:22514276, PMID:23085483, PMID:26187182, PMID:26279430, PMID:26392562 MGI:MGI:3623302, MGI:MGI:5824815 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 ISO (PMID:21078353), (PMID:25239001)
(PMID:25725044)
UniProtKB
RGD
PMID:9603190, PMID:15664695, PMID:17273863, PMID:21078353, PMID:25239001, PMID:25725044 RGD:1599536, RGD:2289022, RGD:69984 NCBI chrNW_004936512:9,164,310...9,281,795 JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO (PMID:17145499) UniProtKB
RGD
PMID:15664695, PMID:17145499 RGD:1599536 NCBI chrNW_004936469:13,063,971...13,153,030 JBrowse link
G Tpcn1 two pore segment channel 1 ISO (MGI:MGI:6316576|PMID:29562233) UniProt PMID:29562233 MGI:MGI:6316576 NCBI chrNW_004936668:3,111,038...3,162,163 JBrowse link
voltage-gated sodium channel activity involved in AV node cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO (PMID:18616619) BHF-UCL PMID:18616619 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
voltage-gated sodium channel activity involved in bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO (PMID:18065446) BHF-UCL PMID:18065446 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
voltage-gated sodium channel activity involved in cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:19808477)
(MGI:MGI:3763979|PMID:17884088)
BHF-UCL PMID:17884088, PMID:19808477 MGI:MGI:3763979 NCBI chrNW_004936570:1,187,916...1,195,423 JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO (PMID:19808477) BHF-UCL PMID:19808477 NCBI chrNW_004936542:3,262,161...3,274,545 JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 ISO (PMID:21051419)
(MGI:MGI:5294649|PMID:19351516)
(PMID:20042427)
BHF-UCL
MGI
PMID:19351516, PMID:20042427, PMID:21051419 MGI:MGI:5294649 NCBI chrNW_004936542:8,082,487...8,106,154 JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 ISO (PMID:17592081) BHF-UCL PMID:17592081 NCBI chrNW_004936542:3,236,238...3,252,550 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO (PMID:18616619), (PMID:21895525), (PMID:22529811)
(MGI:MGI:6402838|PMID:32109384)
(MGI:MGI:5824815|PMID:26187182)
(MGI:MGI:2179151|PMID:11972032)
(PMID:18065446)
BHF-UCL
MGI
PMID:11972032, PMID:18065446, PMID:18616619, PMID:21895525, PMID:22529811, PMID:26187182, PMID:32109384 MGI:MGI:2179151, MGI:MGI:5824815, MGI:MGI:6402838 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
voltage-gated sodium channel activity involved in Purkinje myocyte action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:18464934) BHF-UCL PMID:18464934 NCBI chrNW_004936570:1,187,916...1,195,423 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO (PMID:22766342) BHF-UCL PMID:22766342 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
voltage-gated sodium channel activity involved in SA node cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO (PMID:18616619)
(MGI:MGI:4354492|PMID:15932895)
BHF-UCL
MGI
PMID:15932895, PMID:18616619 MGI:MGI:4354492 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 13947
    transporter activity 763
      transmembrane transporter activity 687
        ion transmembrane transporter activity 597
          ion channel activity 321
            cation channel activity 254
              sodium channel activity 35
                voltage-gated sodium channel activity 20
                  mechanosensitive voltage-gated sodium channel activity 0
                  voltage-gated sodium channel activity involved in cardiac muscle cell action potential + 5
Path 2
Term Annotations click to browse term
  molecular_function 13947
    transporter activity 763
      transmembrane transporter activity 687
        ion transmembrane transporter activity 597
          cation transmembrane transporter activity 439
            inorganic cation transmembrane transporter activity 404
              metal ion transmembrane transporter activity 310
                sodium ion transmembrane transporter activity 109
                  sodium channel activity 35
                    voltage-gated sodium channel activity 20
                      mechanosensitive voltage-gated sodium channel activity 0
                      voltage-gated sodium channel activity involved in cardiac muscle cell action potential + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.