Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:voltage-gated sodium channel activity
go back to main search page
Accession:GO:0005248 term browser browse the term
Definition:Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms:exact_synonym: voltage-dependent sodium channel activity;   voltage-gated sodium ion channel activity;   voltage-sensitive sodium channel
 xref: reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol"


show annotations for term's descendants           Sort by:
 
voltage-gated sodium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic2 acid sensing ion channel subunit 2 IDA RGD PMID:9368048 RGD:1298619 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IEA
ISO
GO_REF:0000107
(PMID:22748890)
Ensembl
RGD
PMID:22748890 GO_REF:0000107 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 IEA
ISO
GO_REF:0000107
(PMID:22748890)
Ensembl
RGD
PMID:22748890 GO_REF:0000107 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215
JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 ISO (PMID:22748890) RGD PMID:22748890 NCBI chr 2:188,458,851...188,471,916
Ensembl chr 2:188,454,853...188,471,988
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 IEA
ISO
GO_REF:0000107
(PMID:22748890)
Ensembl
RGD
PMID:22748890 GO_REF:0000107 NCBI chr 8:63,599,907...63,637,327
Ensembl chr 8:63,600,663...63,639,654
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO
IBA
(PMID:11252306), (PMID:27071085)
PMID:21873635
RGD PMID:11252306, PMID:27071085, PMID:21873635 RGD:13792537 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IDA
IBA
ISO
PMID:21873635
(PMID:9839820)
(MGI:MGI:3590477|PMID:16029194)
RGD PMID:9839820, PMID:16029194, PMID:8538791, PMID:21873635 MGI:MGI:3590477, RGD:69979, RGD:13792537 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 ISO
IBA
IEA
(MGI:MGI:3590477|PMID:16029194)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:16029194, PMID:21873635 GO_REF:0000107, MGI:MGI:3590477, RGD:13792537 NCBI chr 8:128,450,793...128,527,510
Ensembl chr 8:128,450,801...128,521,109
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 TAS
IBA
ISO
IEA
IMP
IC
IDA
PMID:21873635
MGI:MGI:3665322 (MGI:MGI:3664677|PMID:16921370), (MGI:MGI:5796061|PMID:27281198)
GO_REF:0000107
GO_REF:0000002
RGD
Ensembl
InterPro
PMID:16921370, PMID:27281198, PMID:3754035, PMID:21873635, PMID:17273863, PMID:15917456, PMID:15664695 GO_REF:0000002, GO_REF:0000107, MGI:MGI:3664677, MGI:MGI:5796061, RGD:68844, RGD:13792537, RGD:2289022, RGD:2289019, RGD:1599536 NCBI chr 3:52,388,811...52,533,365
Ensembl chr 3:52,381,975...52,510,507
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:14622265), (PMID:19808477) RGD PMID:14622265, PMID:19808477 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 IDA
IBA
ISO
IEA
IC
PMID:21873635
PMID:28029095
(PMID:28256214)
GO_REF:0000107
GO_REF:0000002
(MGI:MGI:2179539|PMID:10827969)
PMID:24297919
RGD
Ensembl
InterPro
PMID:10827969, PMID:28256214, PMID:2442385, PMID:21873635, PMID:28029095, PMID:24297919, PMID:15917456, PMID:15664695 GO_REF:0000002, GO_REF:0000107, MGI:MGI:2179539, RGD:1299025, RGD:13792537, RGD:14390052, RGD:8554774, RGD:2289019, RGD:1599536 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 IDA RGD PMID:8521473 RGD:729729 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 TAS
IBA
IEA
IDA
PMID:21873635
GO_REF:0000002
InterPro PMID:14523090, PMID:21873635, PMID:15664695 GO_REF:0000002, RGD:734493, RGD:13792537, RGD:1599536 NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 TAS
IBA
ISO
IEA
ISS
PMID:21873635
(PMID:12766226), (PMID:30190309)
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3623302|PMID:11834499)
RGD
Ensembl
UniProt
PMID:11834499, PMID:12766226, PMID:30190309, PMID:9613589, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3623302, RGD:634040, RGD:13792537 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764
JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 ISO (MGI:MGI:4462719|PMID:20566860)
(PMID:12930796)
RGD PMID:12930796, PMID:20566860 MGI:MGI:4462719 NCBI chr 8:49,441,106...49,456,279
Ensembl chr 8:49,441,106...49,456,279
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 IEA
IBA
ISO
ISS
GO_REF:0000002
PMID:21873635
MGI:MGI:5825293|MGI:MGI:5825295 (MGI:MGI:3623302|PMID:11834499), (MGI:MGI:5824815|PMID:26187182)
(PMID:14500339), (PMID:19074138), (PMID:19808477), (PMID:19943616), (PMID:21895525), (PMID:22514276), (PMID:23085483), (PMID:26279430), (PMID:26392562)
GO_REF:0000024
InterPro
RGD
UniProt
PMID:11834499, PMID:14500339, PMID:19074138, PMID:19808477, PMID:19943616, PMID:21895525, PMID:22514276, PMID:23085483, PMID:26187182, PMID:26279430, PMID:26392562, PMID:21873635 GO_REF:0000002, GO_REF:0000024, MGI:MGI:3623302, MGI:MGI:5824815, RGD:13792537 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:52,775,779...52,877,365
Ensembl chr 3:52,777,214...52,849,907
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 IDA
IBA
ISO
IEA
IMP
IC
PMID:21873635
(PMID:21078353), (PMID:25239001), (PMID:25725044)
GO_REF:0000107
GO_REF:0000002
RGD
Ensembl
InterPro
PMID:21078353, PMID:25239001, PMID:25725044, PMID:9603190, PMID:21873635, PMID:17273863, PMID:15917456, PMID:15664695 GO_REF:0000002, GO_REF:0000107, RGD:69984, RGD:13792537, RGD:2289022, RGD:2289019, RGD:1599536 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 IDA
IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:17145499)
UniProt
RGD
PMID:17145499, PMID:15664695, PMID:21873635 GO_REF:0000024, RGD:1599536, RGD:13792537 NCBI chr 3:52,583,953...52,664,209
Ensembl chr 3:52,583,951...52,664,209
JBrowse link
G Tpcn1 two pore segment channel 1 ISO (MGI:MGI:6316576|PMID:29562233) RGD PMID:29562233 MGI:MGI:6316576 NCBI chr12:41,507,784...41,566,847
Ensembl chr12:41,543,696...41,566,847
JBrowse link
voltage-gated sodium channel activity involved in AV node cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18616619)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18616619 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
voltage-gated sodium channel activity involved in bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18065446)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18065446 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
voltage-gated sodium channel activity involved in cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:19808477)
(MGI:MGI:3763979|PMID:17884088)
RGD PMID:17884088, PMID:19808477 MGI:MGI:3763979 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO (PMID:19808477) RGD PMID:19808477 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 ISO MGI:MGI:5294639 (MGI:MGI:5294649|PMID:19351516)
(PMID:20042427), (PMID:21051419)
RGD PMID:19351516, PMID:20042427, PMID:21051419 MGI:MGI:5294649 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:49,441,106...49,456,279
Ensembl chr 8:49,441,106...49,456,279
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISS
ISO
GO_REF:0000024
MGI:MGI:2179753|MGI:MGI:5825293|MGI:MGI:5825295 (MGI:MGI:2179151|PMID:11972032), (MGI:MGI:5824815|PMID:26187182), (MGI:MGI:6402838|PMID:32109384)
(PMID:18065446), (PMID:18616619), (PMID:21895525), (PMID:22529811)
BHF-UCL
RGD
PMID:11972032, PMID:18065446, PMID:18616619, PMID:21895525, PMID:22529811, PMID:26187182, PMID:32109384 GO_REF:0000024, MGI:MGI:2179151, MGI:MGI:5824815, MGI:MGI:6402838 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
voltage-gated sodium channel activity involved in Purkinje myocyte action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:18464934) RGD PMID:18464934 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:22766342)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:22766342 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
voltage-gated sodium channel activity involved in SA node cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
ISS
IEA
MGI:MGI:2179753 (MGI:MGI:4354492|PMID:15932895)
(PMID:18616619)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:15932895, PMID:18616619 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4354492 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20457
    transporter activity 1244
      transmembrane transporter activity 1107
        ion transmembrane transporter activity 891
          ion channel activity 443
            cation channel activity 346
              sodium channel activity 43
                voltage-gated sodium channel activity 24
                  mechanosensitive voltage-gated sodium channel activity 0
                  voltage-gated sodium channel activity involved in cardiac muscle cell action potential + 5
Path 2
Term Annotations click to browse term
  molecular_function 20457
    transporter activity 1244
      transmembrane transporter activity 1107
        ion transmembrane transporter activity 891
          cation transmembrane transporter activity 642
            inorganic cation transmembrane transporter activity 593
              metal ion transmembrane transporter activity 434
                sodium ion transmembrane transporter activity 147
                  sodium channel activity 43
                    voltage-gated sodium channel activity 24
                      mechanosensitive voltage-gated sodium channel activity 0
                      voltage-gated sodium channel activity involved in cardiac muscle cell action potential + 5
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.