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ONTOLOGY REPORT - ANNOTATIONS


Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 ISO (MGI:MGI:6271573|PMID:29366904)
(PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904)
PMID:15284189
(MGI:MGI:2157676|PMID:11397787), (MGI:MGI:3042529|PMID:15084279)
UniProt
BHF-UCL
CAFA
MGI
RGD
PMID:1696265, PMID:11397787, PMID:15048573, PMID:15084279, PMID:15284189, PMID:16731531, PMID:16790700, PMID:23348765, PMID:29366904 MGI:MGI:2157676, MGI:MGI:3042529, MGI:MGI:6271573, RGD:12793029, RGD:1580399, RGD:1582674 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
JBrowse link
G Gja10 gap junction protein alpha 10 ISO (MGI:MGI:1336986|PMID:10329667) MGI PMID:10329667 MGI:MGI:1336986 NCBI chrNW_004955411:16,586,673...16,601,999
Ensembl chrNW_004955411:16,593,576...16,595,042
JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to ISO (PMID:19756179) RGD
UniProt
PMID:16123426, PMID:19756179 RGD:1598965 NCBI chrNW_004955568:514,905...516,551
Ensembl chrNW_004955568:515,113...516,435
JBrowse link
G Gjb1 gap junction protein beta 1 ISO RGD PMID:12119284 RGD:728476 NCBI chrNW_004955475:10,779,415...10,787,910
Ensembl chrNW_004955475:10,785,996...10,787,910
JBrowse link
G Gjb2 gap junction protein beta 2 ISO (PMID:12767933), (PMID:21094651)
(MGI:MGI:3603482|PMID:15692151)
UniProt
RGD
PMID:12767933, PMID:15692151, PMID:21094651, PMID:23232329 MGI:MGI:3603482, RGD:7349364 NCBI chrNW_004955497:987,213...989,477
Ensembl chrNW_004955497:988,422...989,099
JBrowse link
G Gjb4 gap junction protein beta 4 ISO (MGI:MGI:3603482|PMID:15692151) UniProt PMID:15692151 MGI:MGI:3603482 NCBI chrNW_004955452:12,871,548...12,874,019
Ensembl chrNW_004955452:12,871,548...12,874,019
JBrowse link
G Gjb6 gap junction protein beta 6 ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360
JBrowse link
G Gjb7 gap junction protein beta 7 ISO (PMID:12064583) UniProtKB PMID:12064583 NCBI chrNW_004955411:14,285,142...14,303,036 JBrowse link
G Gjc1 gap junction protein gamma 1 ISO RGD PMID:11668048 RGD:628534 NCBI chrNW_004955451:17,626,859...17,639,002
Ensembl chrNW_004955451:17,626,859...17,630,247
JBrowse link
G Gjc2 gap junction protein gamma 2 ISO (MGI:MGI:2153053|PMID:11160382) MGI PMID:11160382 MGI:MGI:2153053 NCBI chrNW_004955581:291,537...294,752 JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470
JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004955413:33,220,145...33,224,241
Ensembl chrNW_004955413:33,220,140...33,224,344
JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 ISO (PMID:16790700), (PMID:20606116), (PMID:23348765) BHF-UCL PMID:16790700, PMID:20606116, PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 ISO (PMID:22247482) BHF-UCL PMID:22247482 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
JBrowse link
G Gjc1 gap junction protein gamma 1 ISO (MGI:MGI:5544102|PMID:22982984) BHF-UCL PMID:22982984 MGI:MGI:5544102 NCBI chrNW_004955451:17,626,859...17,639,002
Ensembl chrNW_004955451:17,626,859...17,630,247
JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 ISO (PMID:22247482) BHF-UCL PMID:22247482 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 ISO (PMID:16790700)
(PMID:23348765)
BHF-UCL PMID:16790700, PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 ISO (PMID:1696265) BHF-UCL PMID:1696265 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
JBrowse link
G Gjb2 gap junction protein beta 2 ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:987,213...989,477
Ensembl chrNW_004955497:988,422...989,099
JBrowse link
G Gjb6 gap junction protein beta 6 ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360
JBrowse link
G Gjc2 gap junction protein gamma 2 ISO (PMID:17344063) UniProtKB PMID:17344063 NCBI chrNW_004955581:291,537...294,752 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 ISO (PMID:29366904) UniProt PMID:29366904 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
JBrowse link
G Gja5 gap junction protein alpha 5 ISO (PMID:23348765) BHF-UCL PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
JBrowse link
G Panx1 pannexin 1 NOT ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 13906
    transporter activity 736
      transmembrane transporter activity 681
        passive transmembrane transporter activity 357
          channel activity 357
            wide pore channel activity 16
              gap junction channel activity 13
                gap junction channel activity involved in cell communication by electrical coupling + 6
                gap junction hemi-channel activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.