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ONTOLOGY REPORT - ANNOTATIONS


Term:intracellular calcium activated chloride channel activity
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Accession:GO:0005229 term browser browse the term
Definition:Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
Synonyms:xref: Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region";   reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region";   reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region";   reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region"


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intracellular calcium activated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1, calcium activated chloride channel ISO
IBA
IDA
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:3815244|PMID:18724360), (MGI:MGI:4838963|PMID:20056604), (MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5461590|PMID:22634729), (MGI:MGI:5486597|PMID:23576756), (MGI:MGI:5496475|PMID:23532839), (MGI:MGI:6316357|PMID:28561733)
MGI
GO_Central
RGD
PMID:18724360, PMID:20056604, PMID:21873635, PMID:22075693, PMID:22634729, PMID:23532839, PMID:23576756, PMID:28561733 GO_REF:0000096, MGI:MGI:3815244, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:4838963, MGI:MGI:5448512, MGI:MGI:5461590, MGI:MGI:5486597, MGI:MGI:5496475, MGI:MGI:6201960, MGI:MGI:6316357 NCBI chr 7:144,588,549...144,752,026
Ensembl chr 7:144,588,549...144,751,974
JBrowse link
G Ano10 anoctamin 10 NOT IDA
ISO
(MGI:MGI:5496475|PMID:23532839)
(PMID:22946059)
MGI
UniProtKB
PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr 9:122,175,874...122,294,444
Ensembl chr 9:122,175,874...122,294,423
JBrowse link
G Ano2 anoctamin 2 IMP
IBA
IDA
ISO
(MGI:MGI:5050576|PMID:21516098)
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:3848635|PMID:19474308), (MGI:MGI:4412429|PMID:19561302), (MGI:MGI:4413547|PMID:19475416), (MGI:MGI:4838963|PMID:20056604), (MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5496475|PMID:23532839)
MGI
GO_Central
UniProtKB
RGD
PMID:19474308, PMID:19475416, PMID:19561302, PMID:20056604, PMID:21516098, PMID:21873635, PMID:22075693, PMID:23532839 GO_REF:0000096, MGI:MGI:3848635, MGI:MGI:4412429, MGI:MGI:4413547, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:4838963, MGI:MGI:5050576, MGI:MGI:5448512, MGI:MGI:5496475, MGI:MGI:6201960 NCBI chr 6:125,690,419...126,040,133
Ensembl chr 6:125,690,419...126,040,126
JBrowse link
G Ano3 anoctamin 3 NOT IDA (MGI:MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:MGI:5496475 NCBI chr 2:110,655,201...110,950,391
Ensembl chr 2:110,655,201...110,950,923
JBrowse link
G Ano4 anoctamin 4 NOT IDA
ISO
(MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5496475|PMID:23532839)
(PMID:22946059)
UniProtKB
UniProtKB
PMID:22075693, PMID:22946059, PMID:23532839 MGI:MGI:5448512, MGI:MGI:5496475 NCBI chr10:88,948,932...89,345,205
Ensembl chr10:88,948,994...89,344,762
JBrowse link
G Ano5 anoctamin 5 NOT IDA
ISO
(MGI:MGI:5496475|PMID:23532839)
(PMID:22946059)
MGI
UniProtKB
PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr 7:51,510,007...51,598,707
Ensembl chr 7:51,511,029...51,598,709
JBrowse link
G Ano6 anoctamin 6 NOT IMP
IDA
(MGI:MGI:5527313|PMID:23159814)
(MGI:MGI:4838963|PMID:20056604), (MGI:MGI:6316485|PMID:30785399)
(MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5496475|PMID:23532839)
MGI
UniProtKB
PMID:20056604, PMID:22075693, PMID:23159814, PMID:23532839, PMID:30785399 MGI:MGI:4838963, MGI:MGI:5448512, MGI:MGI:5496475, MGI:MGI:5527313, MGI:MGI:6316485 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Ano7 anoctamin 7 NOT IDA (MGI:MGI:4838963|PMID:20056604)
(MGI:MGI:5496475|PMID:23532839)
MGI PMID:20056604, PMID:23532839 MGI:MGI:4838963, MGI:MGI:5496475 NCBI chr 1:93,373,796...93,404,304
Ensembl chr 1:93,373,930...93,404,303
JBrowse link
G Ano8 anoctamin 8 NOT IDA
ISO
(MGI:MGI:5496475|PMID:23532839)
(PMID:22946059)
MGI
UniProtKB
PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr 8:71,476,016...71,486,092
Ensembl chr 8:71,476,019...71,485,963
JBrowse link
G Ano9 anoctamin 9 NOT IDA
ISO
(MGI:MGI:5496475|PMID:23532839)
(PMID:22946059)
MGI
UniProtKB
PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr 7:141,101,212...141,117,806
Ensembl chr 7:141,101,212...141,117,806
JBrowse link
G Clca1 chloride channel accessory 1 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:145,004,537...145,032,776
Ensembl chr 3:145,003,817...145,032,776
JBrowse link
G Clca2 chloride channel accessory 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:145,070,260...145,099,443
Ensembl chr 3:145,070,263...145,099,443
JBrowse link
G Clca3a1 chloride channel accessory 3A1 IDA
IBA
(MGI:MGI:1314902|PMID:9822685)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:9822685, PMID:21873635 MGI:MGI:1314902, MGI:MGI:6201960 NCBI chr 3:144,729,677...144,760,977
Ensembl chr 3:144,729,677...144,760,977
JBrowse link
G Clca3a2 chloride channel accessory 3A2 ISA
IBA
(MGI:MGI:2152633|PMID:11483609)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:11483609, PMID:21873635 MGI:MGI:2152633, MGI:MGI:6201960 NCBI chr 3:144,780,581...144,819,623
Ensembl chr 3:144,796,559...144,819,494
JBrowse link
G Clca3b chloride channel accessory 3B IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:144,822,623...144,849,302
Ensembl chr 3:144,822,623...144,849,357
JBrowse link
G Clca4a chloride channel accessory 4A IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:144,952,486...144,975,045
Ensembl chr 3:144,952,480...144,975,045
JBrowse link
G Clca4b chloride channel accessory 4B IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:144,910,921...144,932,529
Ensembl chr 3:144,910,921...144,932,529
JBrowse link
G Clns1a chloride channel, nucleotide-sensitive, 1A ISO (PMID:15905169) CAFA PMID:15905169 NCBI chr 7:97,696,657...97,720,793
Ensembl chr 7:97,696,634...97,720,796
JBrowse link
G Nmur2 neuromedin U receptor 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:56,024,990...56,040,987
Ensembl chr11:56,024,987...56,041,010
JBrowse link
G Ttyh1 tweety family member 1 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:4,119,530...4,135,407
Ensembl chr 7:4,119,408...4,136,708
JBrowse link
G Ttyh2 tweety family member 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:114,675,468...114,720,984
Ensembl chr11:114,675,431...114,720,977
JBrowse link
G Ttyh3 tweety family member 3 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 5:140,620,577...140,649,071
Ensembl chr 5:140,620,578...140,649,031
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 23100
    transporter activity 1119
      transmembrane transporter activity 1031
        passive transmembrane transporter activity 474
          channel activity 474
            gated channel activity 333
              ion gated channel activity 49
                intracellular calcium activated chloride channel activity 22
Path 2
Term Annotations click to browse term
  molecular_function 23100
    transporter activity 1119
      transmembrane transporter activity 1031
        passive transmembrane transporter activity 474
          channel activity 474
            ion channel activity 430
              anion channel activity 86
                chloride channel activity 76
                  intracellular chloride channel activity 22
                    intracellular calcium activated chloride channel activity 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.