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ONTOLOGY REPORT - ANNOTATIONS


Term:intracellular calcium activated chloride channel activity
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Accession:GO:0005229 term browser browse the term
Definition:Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
Synonyms:xref: Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region";   reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region";   reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region";   reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region"


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intracellular calcium activated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1 IMP
IBA
ISO
IDA
PMID:21873635
(MGI:MGI:3815244|PMID:18724360), (MGI:MGI:4838963|PMID:20056604), (MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5461590|PMID:22634729), (MGI:MGI:5486597|PMID:23576756), (MGI:MGI:5496475|PMID:23532839), (MGI:MGI:6316357|PMID:28561733)
(PMID:21984732), (PMID:22178883), (PMID:22946059)
PMID:25201006
RGD PMID:18724360, PMID:20056604, PMID:21984732, PMID:22075693, PMID:22178883, PMID:22634729, PMID:22946059, PMID:23532839, PMID:23576756, PMID:28561733, PMID:20421283, PMID:21873635, PMID:25201006, PMID:24081981 MGI:MGI:3815244, MGI:MGI:4838963, MGI:MGI:5448512, MGI:MGI:5461590, MGI:MGI:5486597, MGI:MGI:5496475, MGI:MGI:6316357, RGD:9684846, RGD:13792537, RGD:10047211, RGD:9684847 NCBI chr 1:217,754,349...217,902,540
Ensembl chr 1:217,754,336...217,902,473
JBrowse link
G Ano10 anoctamin 10 NOT ISO (MGI:MGI:5496475|PMID:23532839)
(PMID:21984732)
(PMID:22946059)
RGD PMID:21984732, PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr 8:130,812,941...130,931,021
Ensembl chr 8:130,813,214...130,930,990
JBrowse link
G Ano2 anoctamin 2 IDA
IBA
IMP
ISO
PMID:21873635
(PMID:19474308), (PMID:21984732)
MGI:MGI:5052299 (MGI:MGI:3848635|PMID:19474308), (MGI:MGI:4412429|PMID:19561302), (MGI:MGI:4413547|PMID:19475416), (MGI:MGI:4838963|PMID:20056604), (MGI:MGI:5050576|PMID:21516098), (MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5496475|PMID:23532839)
RGD PMID:19474308, PMID:19475416, PMID:19561302, PMID:20056604, PMID:21516098, PMID:21984732, PMID:22075693, PMID:23532839, PMID:24081981, PMID:21873635, PMID:24081981 MGI:MGI:3848635, MGI:MGI:4412429, MGI:MGI:4413547, MGI:MGI:4838963, MGI:MGI:5050576, MGI:MGI:5448512, MGI:MGI:5496475, RGD:9684847, RGD:13792537, RGD:9684847 NCBI chr 4:158,222,650...158,577,595
Ensembl chr 4:158,224,000...158,576,978
JBrowse link
G Ano3 anoctamin 3 NOT ISO
IBA
(MGI:MGI:5496475|PMID:23532839)
PMID:21873635
(PMID:21984732)
RGD PMID:21984732, PMID:23532839, PMID:21873635 MGI:MGI:5496475, RGD:13792537 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Ano4 anoctamin 4 NOT ISO
IBA
(PMID:22946059)
PMID:21873635
(MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5496475|PMID:23532839)
RGD PMID:22075693, PMID:22946059, PMID:23532839, PMID:21873635 MGI:MGI:5448512, MGI:MGI:5496475, RGD:13792537 NCBI chr 7:29,492,017...30,025,587
Ensembl chr 7:29,492,016...29,701,721
JBrowse link
G Ano5 anoctamin 5 NOT ISO (MGI:MGI:5496475|PMID:23532839)
(PMID:22075693)
(PMID:22946059)
RGD PMID:22075693, PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr 1:106,873,580...106,971,769
Ensembl chr 1:106,896,790...106,968,885
JBrowse link
G Ano6 anoctamin 6 NOT ISO (PMID:22946059)
(MGI:MGI:4838963|PMID:20056604), (MGI:MGI:5527313|PMID:23159814), (MGI:MGI:6316485|PMID:30785399)
(MGI:MGI:5448512|PMID:22075693), (MGI:MGI:5496475|PMID:23532839)
(PMID:21984732)
RGD PMID:20056604, PMID:21984732, PMID:22075693, PMID:22946059, PMID:23159814, PMID:23532839, PMID:30785399 MGI:MGI:4838963, MGI:MGI:5448512, MGI:MGI:5496475, MGI:MGI:5527313, MGI:MGI:6316485 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Ano7 anoctamin 7 NOT ISO (MGI:MGI:4838963|PMID:20056604)
(PMID:21984732), (PMID:22075693)
(PMID:22946059)
(MGI:MGI:5496475|PMID:23532839)
RGD PMID:20056604, PMID:21984732, PMID:22075693, PMID:22946059, PMID:23532839 MGI:MGI:4838963, MGI:MGI:5496475 NCBI chr 9:100,511,610...100,551,798
Ensembl chr 9:100,511,610...100,551,798
JBrowse link
G Ano8 anoctamin 8 NOT ISO (MGI:MGI:5496475|PMID:23532839)
(PMID:21984732), (PMID:22178883)
(PMID:22946059)
RGD PMID:21984732, PMID:22178883, PMID:22946059, PMID:23532839 MGI:MGI:5496475 NCBI chr16:19,884,661...19,894,608
Ensembl chr16:19,886,051...19,894,591
JBrowse link
G Ano9 anoctamin 9 NOT ISO
IBA
(MGI:MGI:5496475|PMID:23532839)
PMID:21873635
(PMID:21984732), (PMID:22178883)
(PMID:22946059)
RGD PMID:21984732, PMID:22178883, PMID:22946059, PMID:23532839, PMID:21873635 MGI:MGI:5496475, RGD:13792537 NCBI chr 1:213,908,389...213,929,291
Ensembl chr 1:213,908,982...213,921,208
JBrowse link
G Clca1 chloride channel accessory 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Clca2 chloride channel accessory 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
JBrowse link
G Clca4 chloride channel accessory 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:250,842,939...250,864,060
Ensembl chr 2:250,843,165...250,862,419
JBrowse link
G Clca4l chloride channel calcium activated 4-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:250,785,534...250,805,445
Ensembl chr 2:250,785,534...250,805,445
JBrowse link
G Clca5 chloride channel accessory 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:250,755,976...250,778,269
Ensembl chr 2:250,755,869...250,778,323
JBrowse link
G Clns1a chloride nucleotide-sensitive channel 1A ISO (PMID:15905169) RGD PMID:15905169 NCBI chr 1:162,676,246...162,696,549
Ensembl chr 1:162,676,269...162,696,544
JBrowse link
G Nmur2 neuromedin U receptor 2 ISO (PMID:10899166) RGD PMID:10899166 NCBI chr10:41,392,663...41,408,518
Ensembl chr10:41,392,666...41,408,518
JBrowse link
G Ttyh1 tweety family member 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:73,734,614...73,753,157
Ensembl chr 1:73,734,624...73,753,128
JBrowse link
G Ttyh2 tweety family member 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:103,206,085...103,248,911
Ensembl chr10:103,206,014...103,248,862
JBrowse link
G Ttyh3 tweety family member 3 ISO
IBA
(PMID:16219661)
PMID:21873635
RGD PMID:16219661, PMID:21873635 RGD:13792537 NCBI chr12:16,084,078...16,112,672
Ensembl chr12:16,084,266...16,112,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20467
    transporter activity 1204
      transmembrane transporter activity 1114
        passive transmembrane transporter activity 494
          channel activity 494
            gated channel activity 342
              ion gated channel activity 49
                intracellular calcium activated chloride channel activity 20
Path 2
Term Annotations click to browse term
  molecular_function 20467
    transporter activity 1204
      transmembrane transporter activity 1114
        passive transmembrane transporter activity 494
          channel activity 494
            ion channel activity 443
              anion channel activity 86
                chloride channel activity 75
                  intracellular chloride channel activity 20
                    intracellular calcium activated chloride channel activity 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.