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ONTOLOGY REPORT - ANNOTATIONS

Term:volume-sensitive anion channel activity
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Accession:GO:0005225 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
Synonyms:broad_synonym: volume-regulated channel
 xref: reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region"


show annotations for term's descendants           Sort by:
volume-sensitive anion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRC8A leucine rich repeat containing 8 VRAC subunit A enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:269,209,660...269,238,529
Ensembl chr 1:269,209,693...269,238,521 		JBrowse link
G LRRC8B leucine rich repeat containing 8 VRAC subunit B enables
contributes_to		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:127,067,794...127,136,616
Ensembl chr 4:127,071,057...127,081,071 		JBrowse link
G LRRC8C leucine rich repeat containing 8 VRAC subunit C enables
contributes_to		 IEA Ensembl GO_REF:0000107 NCBI chr 4:126,957,099...127,079,042
Ensembl chr 4:126,957,105...127,037,216 		JBrowse link
G LRRC8D leucine rich repeat containing 8 VRAC subunit D contributes_to
enables		 ISO
IBA
IEA		 (PMID:28193731)
PMID:28833202		 UniProtKB
GO_Central
Ensembl
UniProt		 PMID:28193731 PMID:28833202 GO_REF:0000033 GO_REF:0000107 RGD:13673739 NCBI chr 4:126,751,720...126,883,344
Ensembl chr 4:126,766,211...126,874,275 		JBrowse link
G LRRC8E leucine rich repeat containing 8 VRAC subunit E contributes_to
enables		 ISO
IEA		 (PMID:28193731) UniProtKB
Ensembl		 PMID:28193731 GO_REF:0000107 NCBI chr 2:71,309,404...71,318,225
Ensembl chr 2:71,309,402...71,314,701 		JBrowse link
G SHOC2 SHOC2 leucine rich repeat scaffold protein enables IBA GO_Central GO_REF:0000033 NCBI chr14:121,347,938...121,444,144
Ensembl chr14:121,349,059...121,444,136 		JBrowse link
G TTYH1 tweety family member 1 NOT|enables ISO (PMID:34385445) UniProt PMID:34385445 NCBI chr 6:58,870,792...58,891,600
Ensembl chr 6:58,871,665...58,891,519 		JBrowse link
G TTYH2 tweety family member 2 NOT|enables ISO (PMID:34385445)
(PMID:34824283)		 UniProt PMID:34385445 PMID:34824283 NCBI chr12:6,838,420...6,881,562
Ensembl chr12:6,838,425...6,881,472 		JBrowse link
G TTYH3 tweety family member 3 NOT|enables ISO (PMID:34385445) UniProt PMID:34385445 NCBI chr 3:1,826,284...1,853,522
Ensembl chr 3:1,826,293...1,853,493 		JBrowse link
volume-sensitive chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 enables ISO PMID:1334533 UniProt PMID:1334533 RGD:405650350 NCBI chr13:122,234,731...122,249,889
Ensembl chr13:122,234,736...122,249,867 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 enables
NOT|enables		 IEA
ISO		 (PMID:11182090) Ensembl
MGI		 PMID:11182090 GO_REF:0000107 NCBI chr14:20,037,628...20,127,160
Ensembl chr14:20,026,685...20,127,155 		JBrowse link
G TTYH1 tweety family member 1 enables IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:58,870,792...58,891,600
Ensembl chr 6:58,871,665...58,891,519 		JBrowse link
G TTYH2 tweety family member 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr12:6,838,420...6,881,562
Ensembl chr12:6,838,425...6,881,472 		JBrowse link
G TTYH3 tweety family member 3 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:1,826,284...1,853,522
Ensembl chr 3:1,826,293...1,853,493 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19432
    transporter activity 1220
      transmembrane transporter activity 1112
        monoatomic ion transmembrane transporter activity 730
          monoatomic ion channel activity 447
            monoatomic anion channel activity 104
              volume-sensitive anion channel activity 11
                volume-sensitive chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 19432
    transporter activity 1220
      transmembrane transporter activity 1112
        passive transmembrane transporter activity 509
          channel activity 509
            monoatomic ion channel activity 447
              monoatomic anion channel activity 104
                volume-sensitive anion channel activity 11
                  volume-sensitive chloride channel activity 5
paths to the root