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ONTOLOGY REPORT - ANNOTATIONS

Term:volume-sensitive anion channel activity
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Accession:GO:0005225 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
Synonyms:broad_synonym: volume-regulated channel
 xref: reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region"


show annotations for term's descendants           Sort by:
volume-sensitive anion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc8a leucine rich repeat containing 8 VRAC subunit A enables ISO
IEA
IBA
ISS
IMP		 (PMID:26824658), (PMID:29769723), (PMID:30095067), (PMID:33139539)
GO_REF:0000107
GO_REF:0000033
(PMID:29769723), (PMID:29773801), (PMID:30135305)
GO_REF:0000024
PMID:28833202		 RGD
Ensembl
GO_Central
UniProt		 PMID:26824658 PMID:29769723 PMID:29773801 PMID:30095067 PMID:30135305 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:13673739 NCBI chr 3:33,902,299...33,934,989
Ensembl chr 3:13,510,513...13,536,202 		JBrowse link
G Lrrc8b leucine rich repeat containing 8 VRAC subunit B contributes_to
enables		 ISO
IEA
IBA		 (PMID:28193731)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:28193731 GO_REF:0000033 GO_REF:0000107 NCBI chr14:4,655,273...4,721,648
Ensembl chr14:4,354,508...4,416,311 		JBrowse link
G Lrrc8c leucine rich repeat containing 8 VRAC subunit C contributes_to
enables		 ISS
ISO
IEA
IMP		 GO_REF:0000024
(PMID:26824658), (PMID:39623139)
GO_REF:0000107
(PMID:29769723)
PMID:28833202		 UniProt
RGD
Ensembl		 PMID:26824658 PMID:29769723 PMID:39623139 PMID:28833202 GO_REF:0000024 GO_REF:0000107, RGD:13673739 NCBI chr14:4,528,721...4,621,259
Ensembl chr14:4,227,832...4,315,249 		JBrowse link
G Lrrc8d leucine rich repeat containing 8 VRAC subunit D contributes_to
enables		 ISS
ISO
IMP		 GO_REF:0000024
(PMID:29773801)
(PMID:26824658), (PMID:32415200)
(PMID:28193731)
PMID:28833202		 UniProt
RGD		 PMID:26824658 PMID:28193731 PMID:29773801 PMID:32415200 PMID:28833202 GO_REF:0000024, RGD:13673739 NCBI chr14:4,335,114...4,411,549
Ensembl chr14:4,029,473...4,135,877 		JBrowse link
G Lrrc8e leucine rich repeat containing 8 VRAC subunit E contributes_to
enables		 ISO
IEA
IBA
ISS		 (PMID:28193731)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024
(PMID:26824658), (PMID:33139539)		 RGD
Ensembl
GO_Central
UniProt		 PMID:26824658 PMID:28193731 PMID:33139539 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr12:7,376,103...7,387,250
Ensembl chr12:2,578,315...2,589,412 		JBrowse link
G Shoc2 SHOC2 leucine-rich repeat scaffold protein enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:262,964,345...263,052,898
Ensembl chr 1:252,959,723...253,047,337 		JBrowse link
G Ttyh1 tweety family member 1 NOT|enables ISO (PMID:34385445) RGD PMID:34385445 NCBI chr 1:79,125,564...79,144,137
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
G Ttyh2 tweety family member 2 NOT|enables ISO (PMID:34385445)
(PMID:34824283)		 RGD PMID:34385445 PMID:34824283 NCBI chr10:100,208,129...100,252,505
Ensembl chr10:99,709,007...99,753,444 		JBrowse link
G Ttyh3 tweety family member 3 NOT|enables ISO (PMID:34385445) RGD PMID:34385445 NCBI chr12:19,110,973...19,139,379
Ensembl chr12:13,997,045...14,025,459 		JBrowse link
volume-sensitive chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 enables IMP PMID:1334533 UniProt PMID:1334533 RGD:405650350 NCBI chr11:93,702,382...93,716,059
Ensembl chr11:80,198,153...80,211,657 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 enables
NOT|enables		 ISO (PMID:12183454)
MGI:2183297 (PMID:11182090)		 RGD PMID:11182090 PMID:12183454 NCBI chr16:34,138,004...34,210,984
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Ttyh1 tweety family member 1 enables ISO
ISS
IBA		 (PMID:16219661)
GO_REF:0000024
(PMID:31138989)
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:16219661 PMID:31138989 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:79,125,564...79,144,137
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
G Ttyh2 tweety family member 2 enables ISO
IBA		 (PMID:31138989)
GO_REF:0000033		 RGD
GO_Central		 PMID:31138989 GO_REF:0000033 NCBI chr10:100,208,129...100,252,505
Ensembl chr10:99,709,007...99,753,444 		JBrowse link
G Ttyh3 tweety family member 3 enables ISO
IBA		 (PMID:31138989)
GO_REF:0000033		 RGD
GO_Central		 PMID:31138989 GO_REF:0000033 NCBI chr12:19,110,973...19,139,379
Ensembl chr12:13,997,045...14,025,459 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        monoatomic ion transmembrane transporter activity 771
          monoatomic ion channel activity 457
            monoatomic anion channel activity 103
              volume-sensitive anion channel activity 11
                volume-sensitive chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        passive transmembrane transporter activity 516
          channel activity 516
            monoatomic ion channel activity 457
              monoatomic anion channel activity 103
                volume-sensitive anion channel activity 11
                  volume-sensitive chloride channel activity 5
paths to the root