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ONTOLOGY REPORT - ANNOTATIONS


Term:intracellularly cAMP-activated cation channel activity
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Accession:GO:0005222 term browser browse the term
Definition:Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.
Synonyms:exact_synonym: intracellular 3',5' cAMP activated cation channel activity;   intracellular adenosine 3',5'-cyclophosphate activated cation channel activity;   intracellular cAMP activated cation channel activity;   intracellular cyclic AMP activated cation channel activity
 broad_synonym: HCN channel activity;   hyperpolarization-activated cyclic nucleotide-gated channel activity


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intracellularly cAMP-activated cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624761:18,992,372...19,004,247
Ensembl chrNW_004624761:18,992,384...19,004,202
JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 enables ISO
IEA
RGD
TreeGrafter
PMID:22786723 GO_REF:0000118 RGD:7241219 NCBI chrNW_004624883:3,043,661...3,051,420
Ensembl chrNW_004624883:3,043,666...3,049,801
JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624749:3,458,997...3,482,697
Ensembl chrNW_004624749:3,458,991...3,483,003
JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 enables ISO
IEA
RGD
TreeGrafter
PMID:22786723 GO_REF:0000118 RGD:7241219 NCBI chrNW_004624817:7,716,951...7,732,177
Ensembl chrNW_004624817:7,719,332...7,737,336
JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 enables ISO
IEA
RGD
TreeGrafter
PMID:22786723 GO_REF:0000118 RGD:7241219 NCBI chrNW_004624746:28,198,324...28,268,280 JBrowse link
G Cngb3 cyclic nucleotide gated channel subunit beta 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624744:5,059,957...5,209,144
Ensembl chrNW_004624744:5,042,494...5,207,818
JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 enables ISO (MGI:5520040|PMID:22006928)
(PMID:30886335)
UniProt
MGI
PMID:22006928 PMID:30886335 MGI:5520040 NCBI chrNW_004624759:9,636,380...10,044,832
Ensembl chrNW_004624759:9,636,457...10,049,403
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 enables ISO (PMID:10228147) UniProt PMID:10228147 NCBI chrNW_004624828:7,889,616...7,908,855
Ensembl chrNW_004624828:7,889,025...7,908,639
JBrowse link
G Hcn3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 NOT|enables ISO (MGI:3589863|PMID:15923185) UniProt PMID:15923185 MGI:3589863 NCBI chrNW_004624885:2,271,991...2,281,575
Ensembl chrNW_004624885:2,272,935...2,281,588
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 enables ISO (PMID:10228147), (PMID:12750403), (PMID:16407510)
(PMID:14657344)
UniProt
MGI
PMID:10228147 PMID:12750403 PMID:14657344 PMID:16407510 NCBI chrNW_004624781:968,608...1,007,969
Ensembl chrNW_004624781:968,748...1,008,200
JBrowse link
intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 enables ISO (PMID:21358644) SynGO PMID:21358644 NCBI chrNW_004624759:9,636,380...10,044,832
Ensembl chrNW_004624759:9,636,457...10,049,403
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16258
    transporter activity 1090
      transmembrane transporter activity 1003
        monoatomic ion transmembrane transporter activity 657
          monoatomic ion channel activity 410
            ligand-gated monoatomic ion channel activity 178
              intracellularly ligand-gated monoatomic ion channel activity 31
                intracellularly cyclic nucleotide-activated monoatomic cation channel activity 12
                  intracellularly cAMP-activated cation channel activity 10
                    intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential 0
                    intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential 1
Path 2
Term Annotations click to browse term
  molecular_function 16258
    transporter activity 1090
      transmembrane transporter activity 1003
        passive transmembrane transporter activity 466
          channel activity 466
            gated channel activity 303
              ligand-gated channel activity 182
                ligand-gated monoatomic ion channel activity 178
                  cyclic nucleotide-activated monoatomic ion channel activity 12
                    intracellularly cyclic nucleotide-activated monoatomic cation channel activity 12
                      intracellularly cAMP-activated cation channel activity 10
                        intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential 0
                        intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential 1
paths to the root