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ONTOLOGY REPORT - ANNOTATIONS

Term:G protein-coupled receptor activity
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Accession:GO:0004930 term browser browse the term
Definition:Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms:exact_synonym: G protein linked receptor activity;   GPCR activity;   ligand-dependent GPCR activity
 narrow_synonym: EBV-induced receptor;   Epstein-Barr Virus-induced receptor activity;   G-protein coupled receptor activity, unknown ligand;   Mas proto-oncogene receptor activity;   RDC1 receptor activity;   SREB receptor;   orphan G protein coupled receptor activity;   orphan GPCR activity;   super conserved receptor expressed in brain receptor activity
 alt_id: GO:0001622;   GO:0001623;   GO:0001624;   GO:0001625;   GO:0016526
 xref: Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13";   Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq";   Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)";   Wikipedia:GPCR;   reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein"

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      molecular_function 189956
        molecular transducer activity 17455
          signaling receptor activity 17455
            transmembrane signaling receptor activity 15495
              G protein-coupled receptor activity 10729
                G protein-coupled GABA receptor activity 29
                G protein-coupled adenosine receptor activity 53
                G protein-coupled amine receptor activity + 428
                G protein-coupled bile acid receptor activity 10
                G protein-coupled chemoattractant receptor activity + 274
                G protein-coupled chemorepellent receptor activity 0
                G protein-coupled cytokinin receptor activity 0
                G protein-coupled estrogen receptor activity 20
                G protein-coupled folate receptor activity 0
                G protein-coupled glucose receptor activity 0
                G protein-coupled glutamate receptor activity + 73
                G protein-coupled neurotransmitter receptor activity + 142
                G protein-coupled nucleotide receptor activity 0
                G protein-coupled olfactory receptor activity 7
                G protein-coupled opioid receptor activity + 53
                G protein-coupled peptide receptor activity + 1098
                G protein-coupled photoreceptor activity 55
                G protein-coupled purinergic nucleotide receptor activity + 111
                G protein-coupled pyrimidinergic nucleotide receptor activity + 31
                G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential + 64
                GPCR taste receptor activity + 0
                bioactive lipid receptor activity + 152
                cannabinoid receptor activity 31
                choriogonadotropin hormone receptor activity 10
                corticotrophin-releasing factor receptor activity 21
                ecdysis-triggering hormone receptor activity 0
                gastric inhibitory peptide receptor activity 10
                gonadotropin-releasing hormone receptor activity 22
                growth hormone secretagogue receptor activity 11
                growth hormone-releasing hormone receptor activity 30
                icosanoid receptor activity + 144
                luteinizing hormone receptor activity 11
                mast cell secretagogue receptor activity 7
                melanin-concentrating hormone receptor activity 10
                melatonin receptor activity 41
                nicotinic acid receptor activity 12
                parathyroid hormone receptor activity 20
                pheromone receptor activity + 253
                pituitary adenylate cyclase-activating polypeptide receptor activity 30
                platelet activating factor receptor activity 12
                prosaposin receptor activity 20
                secretin receptor activity 10
                thyroid-stimulating hormone receptor activity 12
                thyrotropin-releasing hormone receptor activity 14
                vasoactive intestinal polypeptide receptor activity 30
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