Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
go back to main search page
Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052


show annotations for term's descendants           Sort by:
nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor enables
contributes_to		 IDA
ISO
IEA
IBA		 PMID:7812217
(PMID:34521881)
(PMID:10395741), (PMID:28602820), (PMID:32818467), (PMID:32866000)
GO_REF:0000117
GO_REF:0000033
(MGI:49014|PMID:1314586), (PMID:33436590)		 RGD
UniProt
GO_Central		 PMID:1314586 PMID:10395741 PMID:28602820 PMID:32818467 PMID:32866000 More... GO_REF:0000033 GO_REF:0000117 MGI:49014, RGD:8553947 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Ar androgen receptor enables
NOT|enables		 IDA
IEA
ISO
ISS
IBA		 GO_REF:0000107
(PMID:12799378), (PMID:17277772), (PMID:19345326), (PMID:19886863), (PMID:20048160), (PMID:25091737)
(PMID:19244107)
GO_REF:0000024
GO_REF:0000033
(MGI:5882884|PMID:18761815), (PMID:12145204), (PMID:15199138), (PMID:23786676)		 Ensembl
RGD
BHF-UCL
GO_Central		 PMID:12145204 PMID:12799378 PMID:15199138 PMID:17277772 PMID:18761815 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5882884, RGD:1298681 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator enables
contributes_to		 IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:34521881)
MGI:2176696 (PMID:11043581)		 Ensembl
UniProt
RGD		 PMID:11043581 PMID:34521881 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Esr1 estrogen receptor 1 enables IBA
ISO		 GO_REF:0000033
UniProtKB:Q8IX12 (PMID:15831516), (PMID:18722177), (PMID:9338790)
(PMID:15322135)		 GO_Central
RGD		 PMID:9338790 PMID:15322135 PMID:15831516 PMID:18722177 GO_REF:0000033 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 enables ISO
IBA		 (PMID:19126643)
GO_REF:0000033		 RGD
GO_Central		 PMID:19126643 GO_REF:0000033 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Esrrb estrogen-related receptor beta enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791 		JBrowse link
G Esrrg estrogen-related receptor gamma enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:12193589)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:12193589 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hnf4g hepatocyte nuclear factor 4, gamma enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:97,885,773...98,036,650
Ensembl chr 2:97,887,432...98,036,592 		JBrowse link
G Nkx3-1 NK3 homeobox 1 enables ISO (PMID:19886863) RGD PMID:19886863 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:14739254)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:14739254 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 contributes_to
enables		 ISO
IBA
IEA
ISS		 (MGI:4399016|PMID:17107947)
(PMID:14739254)
GO_REF:0000033
GO_REF:0000002
(PMID:19481530)
GO_REF:0000024		 RGD
GO_Central
InterPro
UniProt		 PMID:14739254 PMID:17107947 PMID:19481530 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 MGI:4399016 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 enables IDA
ISO
IBA
IEA		 PMID:10334992
(PMID:27471003)
(MGI:5306122|PMID:21757002), (PMID:27471003)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:21757002 PMID:27471003 PMID:10334992 GO_REF:0000002 GO_REF:0000033 MGI:5306122, RGD:15090836 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1h5 nuclear receptor subfamily 1, group H, member 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:190,461,036...190,481,420
Ensembl chr 2:190,462,256...190,481,211 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 enables IDA
IBA
ISS
ISO		 GO_REF:0000033
GO_REF:0000024
(PMID:12578355)		 GO_Central
UniProt
RGD		 PMID:12578355 PMID:10967130 GO_REF:0000024 GO_REF:0000033, RGD:61490 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 enables ISO
IBA
IEA		 (PMID:9783588)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9783588 GO_REF:0000033 GO_REF:0000107 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr2c1 nuclear receptor subfamily 2, group C, member 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:28,715,347...28,768,624
Ensembl chr 7:28,715,562...28,767,160 		JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902 		JBrowse link
G Nr2e1 nuclear receptor subfamily 2, group E, member 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:46,050,134...46,071,257
Ensembl chr20:46,050,414...46,073,949 		JBrowse link
G Nr2e3 nuclear receptor subfamily 2, group E, member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:60,365,581...60,373,383
Ensembl chr 8:60,366,124...60,373,163 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 enables ISO
IBA
ISS		 (PMID:18798693)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:18798693 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031 		JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 enables ISO
IBA
ISS		 (PMID:17635946)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:17635946 GO_REF:0000024 GO_REF:0000033 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 enables NAS
ISO		 (PMID:23610160), (PMID:8205615) RGD PMID:8205615 PMID:23610160 PMID:12865342 RGD:1598968 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 enables IDA
ISO		 (PMID:15205472) RGD PMID:15205472 PMID:8668203 RGD:68248 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Nr6a1 nuclear receptor subfamily 6, group A, member 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:22,495,109...22,683,132
Ensembl chr 3:22,496,943...22,683,131 		JBrowse link
G Pgr progesterone receptor enables IBA
ISO		 GO_REF:0000033
(PMID:10757795), (PMID:9620806)
(PMID:14681235)		 GO_Central
RGD		 PMID:9620806 PMID:10757795 PMID:14681235 GO_REF:0000033 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables IMP
IBA
ISO		 GO_REF:0000033
(PMID:12955147), (PMID:19955185)		 GO_Central
RGD		 PMID:12955147 PMID:19955185 PMID:12966092 PMID:12189208 GO_REF:0000033, RGD:1580224, RGD:729665 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta enables TAS
IBA
ISO		 GO_REF:0000033
(PMID:12955147)		 GO_Central
RGD		 PMID:12955147 PMID:12573457 GO_REF:0000033, RGD:633662 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:10622252), (PMID:16239304), (PMID:18293083)
GO_REF:0000033
(PMID:16239304)
(MGI:5447618|PMID:16239304)		 UniProt
RGD
GO_Central		 PMID:10622252 PMID:16239304 PMID:18293083 GO_REF:0000024 GO_REF:0000033 MGI:5447618 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rara retinoic acid receptor, alpha enables TAS
ISO
IBA		 (PMID:15322135), (PMID:15528198)
GO_REF:0000033
(PMID:21131358), (PMID:2825025)		 RGD
GO_Central		 PMID:2825025 PMID:15322135 PMID:15528198 PMID:21131358 PMID:12193579 GO_REF:0000033, RGD:625676 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarb retinoic acid receptor, beta enables NAS
IBA
ISO		 GO_REF:0000033
(PMID:2177841)		 GO_Central
RGD		 PMID:2177841 PMID:1655630 GO_REF:0000033, RGD:704353 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma enables IMP
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11072095 GO_REF:0000033, RGD:1300463 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Rora RAR-related orphan receptor A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rorb RAR-related orphan receptor B enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390 		JBrowse link
G Rorc RAR-related orphan receptor C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rxra retinoid X receptor alpha contributes_to
enables		 ISO
IBA		 (MGI:4399016|PMID:17107947)
(PMID:1651173), (PMID:20219900), (PMID:25592151), (PMID:7990953), (PMID:9267036)
(PMID:1312497), (PMID:15322135)
GO_REF:0000033		 RGD
GO_Central		 PMID:1312497 PMID:1651173 PMID:7990953 PMID:9267036 PMID:15322135 More... GO_REF:0000033 MGI:4399016 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:1662118), (PMID:7990953)		 GO_Central
RGD		 PMID:1662118 PMID:7990953 PMID:1662118 GO_REF:0000033, RGD:729677 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Rxrg retinoid X receptor gamma enables IBA
ISO		 GO_REF:0000033
(PMID:1312497)		 GO_Central
RGD		 PMID:1312497 GO_REF:0000033 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 enables ISO (PMID:23610160) RGD PMID:23610160 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 enables ISO
IEA		 (PMID:17324931)
GO_REF:0000107		 RGD
Ensembl		 PMID:17324931 GO_REF:0000107 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Thra thyroid hormone receptor alpha enables ISO
IBA
IEA
ISS		 (PMID:15466465), (PMID:18052923), (PMID:8710870)
(PMID:15322135)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
InterPro
Ensembl
UniProt		 PMID:8710870 PMID:15322135 PMID:15466465 PMID:18052923 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thra_v1 thyroid hormone receptor alpha, variant 1 IDA RGD PMID:12039959 RGD:625494
G Thrb thyroid hormone receptor beta enables TAS
ISO
IBA
IEA
IDA		 MGI:2657173 (PMID:20203194)
GO_REF:0000033
GO_REF:0000107
(PMID:15466465)
GO_REF:0000002		 RGD
GO_Central
Ensembl
InterPro		 PMID:15466465 PMID:20203194 PMID:2457590 PMID:2457590 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:729962, RGD:729962 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Vdr vitamin D receptor enables IDA
ISO
IBA		 (PMID:10678179), (PMID:12016314), (PMID:16549446), (PMID:17082781), (PMID:28698609), (PMID:32354638)
(PMID:15322135)
GO_REF:0000033		 RGD
GO_Central		 PMID:10678179 PMID:12016314 PMID:15322135 PMID:16549446 PMID:17082781 More... GO_REF:0000033, RGD:70308 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 enables IDA
IEA
ISO		 PMID:12718893
GO_REF:0000107
PMID:10334992
(PMID:10334992), (PMID:21757002), (PMID:23767959)		 Ensembl
RGD		 PMID:10334992 PMID:21757002 PMID:23767959 PMID:12718893 PMID:10334992 GO_REF:0000107, RGD:1625198, RGD:15090836 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Vdr vitamin D receptor enables ISO
IEA		 (PMID:12016314)
GO_REF:0000107		 RGD
Ensembl		 PMID:12016314 GO_REF:0000107 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G protein-coupled estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 enables ISO (PMID:16645038) RGD PMID:16645038 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 enables IDA PMID:23283935 UniProt PMID:23283935 RGD:8553898 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 enables IEA
ISO		 GO_REF:0000002
(PMID:15831516), (PMID:9841876)
GO_REF:0000107		 InterPro
RGD
Ensembl		 PMID:9841876 PMID:15831516 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 enables IEA
ISO		 GO_REF:0000002
(PMID:24033289)
(PMID:19126643), (PMID:29261182), (PMID:30113650)
GO_REF:0000107		 InterPro
RGD
Ensembl		 PMID:19126643 PMID:24033289 PMID:29261182 PMID:30113650 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 enables IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(MGI:5512928|PMID:23545157)
(PMID:15539556), (PMID:15705806)		 Ensembl
GO_Central
RGD		 PMID:15539556 PMID:15705806 PMID:23545157 GO_REF:0000033 GO_REF:0000107 MGI:5512928 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO (PMID:31420216), (PMID:35104454) RGD PMID:31420216 PMID:35104454 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 enables IEA
ISO		 GO_REF:0000107
(PMID:15199138), (PMID:7914432), (PMID:9237103)
GO_REF:0000002		 Ensembl
RGD
InterPro		 PMID:7914432 PMID:9237103 PMID:15199138 GO_REF:0000002 GO_REF:0000107 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase enables ISO (PMID:26989199) RGD PMID:26989199 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061 		JBrowse link
G Esr1 estrogen receptor 1 IDA 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 enables IDA
IEA		 17-beta-estradiol (E2)
GO_REF:0000002		 InterPro
RGD		 PMID:17928626 GO_REF:0000002, RGD:5128669 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Esrrb estrogen-related receptor beta enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791 		JBrowse link
G Esrrg estrogen-related receptor gamma enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 TAS RGD PMID:11781314 RGD:625467 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IMP RGD PMID:17260968 RGD:1600931 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Olr59 olfactory receptor 59 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:19389702)		 Ensembl
UniProt
RGD		 PMID:19389702 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179 		JBrowse link
G Paqr7 progestin and adipoQ receptor family member 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:146,709,159...146,720,577
Ensembl chr 5:146,708,900...146,720,673 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340 		JBrowse link
G Pgr progesterone receptor enables IMP
ISO
IEA		 (PMID:16176985)
GO_REF:0000104		 RGD
UniProt		 PMID:16176985 PMID:11113338 GO_REF:0000104, RGD:1601290 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables TAS
ISO		 (PMID:19955185) RGD PMID:19955185 PMID:12189208 RGD:729665 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rxra retinoid X receptor alpha enables TAS
IEA		 GO_REF:0000104 UniProt
RGD		 PMID:12105223 GO_REF:0000104, RGD:625479 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Rxrg retinoid X receptor gamma enables IEA GO_REF:0000002
GO_REF:0000104		 InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20733
    molecular transducer activity 2601
      signaling receptor activity 2601
        nuclear receptor activity 60
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 20
Path 2
Term Annotations click to browse term
  molecular_function 20733
    transcription regulator activity 1659
      DNA-binding transcription factor activity 1207
        DNA-binding transcription factor activity, RNA polymerase II-specific 1149
          nuclear receptor activity 60
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 20
paths to the root