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Term:ubiquitin-protein transferase activity
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Accession:GO:0004842 term browser browse the term
Definition:Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
Synonyms:narrow_synonym: anaphase-promoting complex activity
 related_synonym: E2;   E3;   ubiquitin conjugating enzyme activity;   ubiquitin ligase activity;   ubiquitin protein ligase activity
 alt_id: GO:0004840;   GO:0004841
 xref: KEGG_REACTION:R03876;   Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)";   Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation";   Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer";   Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex";   reactome:R-HSA-1169394 "ISGylation of IRF3";   reactome:R-HSA-1169395 "ISGylation of viral protein NS1";   reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase";   reactome:R-HSA-1169398 "ISGylation of host protein filamin B";   reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes";   reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)";   reactome:R-HSA-1169406 "ISGylation of host proteins";   reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha";   reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha";   reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH";   reactome:R-HSA-1358789 "Self-ubiquitination of RNF41";   reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3";   reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3";   reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)";   reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";   reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2";   reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling";   reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1";   reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex";   reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex";   reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP";   reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex";   reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex";   reactome:R-HSA-179417 "Multiubiquitination of Nek2A";   reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G";   reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex";   reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85";   reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)";   reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)";   reactome:R-HSA-183051 "CBL ubiquitinates Sprouty";   reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix";   reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty";   reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7";   reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21";   reactome:R-HSA-1912357 "ITCH ubiquitinates DTX";   reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand";   reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2";   reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2";   reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer";   reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1";   reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination";   reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling";   reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6";   reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6";   reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF";   reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex";   reactome:R-HSA-211734 "Ubiquitination of PAK-2p34";   reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7";   reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2";   reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3";   reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2";   reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7";   reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3";   reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3";   reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )";   reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels";   reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6";   reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants";   reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants";   reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants";   reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA";   reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56";   reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21";   reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1";   reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2";   reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1";   reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2";   reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins";   reactome:R-HSA-4332236 "CBL neddylates TGFBR2";   reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated";   reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation";   reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1";   reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates";   reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1";   reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments";   reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated";   reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP";   reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex";   reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates";   reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1";   reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1";   reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2";   reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3";   reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA";   reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH";   reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA";   reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP";   reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP";   reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3";   reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK";   reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated";   reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2";   reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2";   reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains";   reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A";   reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO";   reactome:R-HSA-75824 "Ubiquitination of Cyclin D1";   reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4";   reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3";   reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha";   reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3";   reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex";   reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";   reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated";   reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS";   reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2";   reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains";   reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation";   reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane";   reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2";   reactome:R-HSA-983153 "E1 mediated ubiquitin activation";   reactome:R-HSA-983156 "Polyubiquitination of substrate"


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  molecular_function 138763
    catalytic activity 39365
      catalytic activity, acting on a protein 15389
        ubiquitin-like protein transferase activity 3069
          ubiquitin-protein transferase activity 2909
            ubiquitin conjugating enzyme activity 305
            ubiquitin protein ligase activity + 1970
            ubiquitin-calmodulin ligase activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.