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ONTOLOGY REPORT - ANNOTATIONS

Term:thyroxine 5'-deiodinase activity
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Accession:GO:0004800 term browser browse the term
Definition:Catalysis of the reaction: 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + acceptor-H2.
Synonyms:exact_synonym: outer ring-deiodinating pathway
 narrow_synonym: type I iodothyronine deiodinase activity;   type II iodothyronine deiodinase activity
 broad_synonym: thyroxine deiodinase activity
 related_synonym: L-thyroxine iodohydrolase (reducing) activity;   acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating);   diiodothyronine 5'-deiodinase activity;   iodothyronine 5'-deiodinase activity;   iodothyronine outer ring monodeiodinase activity
 xref: EC:1.21.99.4;   MetaCyc:THYROXINE-DEIODINASE-RXN;   RHEA:19745;   reactome:R-HSA-209772 "Thyroxine is deiodinated to triiodothyronine";   reactome:R-HSA-350869 "Thyroxine is deiodinated to reverse triiodothyronine (RT3)"


show annotations for term's descendants           Sort by:
thyroxine 5'-deiodinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 enables IDA
IEA
ISO		 GO_REF:0000002
(PMID:15192045)
(PMID:12586753), (PMID:32718224), (PMID:8419134)
GO_REF:0000116
GO_REF:0000107
GO_REF:0000003
(PMID:12586771), (PMID:32718224)		 InterPro
RGD
RHEA
Ensembl
UniProt		 PMID:8419134 PMID:12586753 PMID:12586771 PMID:15192045 PMID:32718224 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116, RGD:728721 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 enables IDA
ISO
IEA		 (PMID:15192045)
MGI:2182450 (PMID:10715551), (PMID:11731615), (PMID:12586753)
GO_REF:0000002
GO_REF:0000003
GO_REF:0000116
GO_REF:0000107
(PMID:10403186), (PMID:11108274), (PMID:12586771), (PMID:19651899)		 RGD
InterPro
UniProt
RHEA
Ensembl		 PMID:10403186 PMID:10715551 PMID:11108274 PMID:11731615 PMID:12586753 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116, RGD:628323, RGD:1626436 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 enables TAS
ISO
IEA		 MGI:2664293 (PMID:12399446), (PMID:16410833)
GO_REF:0000107
GO_REF:0000002		 RGD
Ensembl
InterPro		 PMID:12399446 PMID:16410833 PMID:7622463 GO_REF:0000002 GO_REF:0000107, RGD:68236 NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      oxidoreductase activity 868
        oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond 4
          thyroxine 5'-deiodinase activity 3
paths to the root