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ONTOLOGY REPORT - ANNOTATIONS


Term:thromboxane-A synthase activity
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Accession:GO:0004796 term browser browse the term
Definition:Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).
Synonyms:narrow_synonym: cytochrome P450 CYP5
 related_synonym: (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity;   (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity;   thromboxane synthase activity;   thromboxane synthetase activity
 alt_id: GO:0008400
 xref: EC:5.3.99.5;   KEGG_REACTION:R02268;   MetaCyc:THROMBOXANE-A-SYNTHASE-RXN;   RHEA:17137;   Reactome:R-HSA-5603275 "Defective TBXAS1 does not isomerise PGH2 to TXA2";   reactome:R-HSA-76500 "TBXAS1 isomerises PGH2 to TXA2"



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thromboxane-A synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2S1 cytochrome P450 family 2 subfamily S member 1 enables ISO (PMID:21068195) UniProt PMID:21068195 NCBI chr 1:112,735,586...112,747,534
Ensembl chr 1:112,736,706...112,747,555
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G TBXAS1 thromboxane A synthase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr16:8,870,283...9,032,105
Ensembl chr16:8,870,284...9,023,462
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  molecular_function 18597
    catalytic activity 5534
      isomerase activity 180
        intramolecular oxidoreductase activity 46
          thromboxane-A synthase activity 2
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