Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:thioredoxin-disulfide reductase activity
go back to main search page
Accession:GO:0004791 term browser browse the term
Definition:Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
Synonyms:exact_synonym: thioredoxin-disulphide reductase activity
 related_synonym: NADP--thioredoxin reductase activity;   NADPH--thioredoxin reductase activity;   NADPH2:oxidized thioredoxin oxidoreductase activity;   NADPH:oxidized thioredoxin oxidoreductase activity;   thioredoxin:NADP+ oxidoreductase activity
 xref: EC:1.8.1.9;   KEGG_REACTION:R02016;   MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN;   RHEA:20345;   reactome:R-HSA-1222485 "TrxB reactivates TrxA";   reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH";   reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+";   reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300"


show annotations for term's descendants           Sort by:
 
thioredoxin-disulfide reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nxn nucleoredoxin enables ISO (MGI:85780|PMID:9119370) RGD PMID:9119370 MGI:85780 NCBI chr10:61,109,323...61,247,576
Ensembl chr10:61,110,020...61,248,251
JBrowse link
G Selenot selenoprotein T enables IDA
IBA
PMID:26866473
PMID:21873635
UniProt
GO_Central
PMID:26866473 PMID:21873635 RGD:12793008, RGD:13792537 NCBI chr 2:142,804,387...142,821,438
Ensembl chr 2:142,804,405...142,821,427
JBrowse link
G Txn1 thioredoxin 1 TAS RGD PMID:12011048 RGD:727213 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txndc2 thioredoxin domain containing 2 enables ISO (PMID:11399755) RGD PMID:11399755 NCBI chr 9:105,230,575...105,235,131
Ensembl chr 9:105,230,578...105,235,126
JBrowse link
G Txnrd1 thioredoxin reductase 1 enables IDA
ISO
IEA
IBA
(MGI:2386187|PMID:11259642)
GO_REF:0000116
GO_REF:0000003
PMID:21873635
RGD
RHEA
UniProt
PMID:11259642 PMID:12435734 PMID:21873635 GO_REF:0000003 GO_REF:0000116 MGI:2386187, RGD:634375, RGD:13792537 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 enables TAS
IDA
IBA
IEA
PMID:9988709
PMID:21873635
GO_REF:0000003
GO_REF:0000116
UniProt
RHEA
PMID:9988709 PMID:9988709 PMID:21873635 GO_REF:0000003 GO_REF:0000116, RGD:61776, RGD:61776, RGD:13792537 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
G Txnrd3 thioredoxin reductase 3 enables IBA
ISO
PMID:21873635
(MGI:2386187|PMID:11259642)
RGD PMID:11259642 PMID:21873635 MGI:2386187, RGD:13792537 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19979
    antioxidant activity 89
      thioredoxin-disulfide reductase activity 7
Path 2
Term Annotations click to browse term
  molecular_function 19979
    catalytic activity 5666
      oxidoreductase activity 818
        oxidoreductase activity, acting on a sulfur group of donors 60
          disulfide oxidoreductase activity 45
            protein-disulfide reductase activity 39
              protein-disulfide reductase (NAD(P)) activity 12
                thioredoxin-disulfide reductase activity 7
paths to the root