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ONTOLOGY REPORT - ANNOTATIONS


Term:sepiapterin reductase activity
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Accession:GO:0004757 term browser browse the term
Definition:Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+.
Synonyms:related_synonym: 7,8-dihydrobiopterin:NADP+ oxidoreductase activity
 xref: EC:1.1.1.153;   MetaCyc:SEPIAPTERIN-REDUCTASE-RXN;   RHEA:18953;   reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)";   reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to BH2"



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sepiapterin reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGD1560795 similar to Sepiapterin reductase (SPR) enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891
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G Spr sepiapterin reductase enables TAS
IDA
IBA
PMID:10350607
PMID:21873635
RGD
UniProt
GO_Central
PMID:2201030 PMID:2179471 PMID:2201030 PMID:10350607 PMID:21873635 RGD:70022, RGD:1600056, RGD:70022, RGD:8554741, RGD:13792537 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678
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  molecular_function 19884
    catalytic activity 5652
      oxidoreductase activity 814
        oxidoreductase activity, acting on CH-OH group of donors 145
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 135
            sepiapterin reductase activity 2
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