Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:pyruvate dehydrogenase (acetyl-transferring) activity
go back to main search page
Accession:GO:0004739 term browser browse the term
Definition:Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
Synonyms:exact_synonym: pyruvate dehydrogenase (lipoamide) activity
 narrow_synonym: MtPDC (mitochondrial pyruvate dehydogenase complex) activity
 related_synonym: PDH;   pyruvate dehydrogenase complex activity;   pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating);   pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
 xref: EC:1.2.4.1;   MetaCyc:RXN0-1134;   RHEA:19189;   Reactome:R-HSA-9861734 "PDH E1 decarboxylates PYR, transferring acetyl to DLAT"


show annotations for term's descendants           Sort by:
pyruvate dehydrogenase (acetyl-transferring) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 enables
contributes_to		 IDA
IEA
ISS
ISO
IBA		 GO_REF:0000003
GO_REF:0000116
GO_REF:0000104
GO_REF:0000024
(PMID:19081061)
GO_REF:0000033		 UniProt
RHEA
RGD
GO_Central		 PMID:19081061 PMID:7487891 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:1599112 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:89,213,172...89,216,067
Ensembl chr16:82,511,511...82,514,372 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 enables IDA
ISO
IBA		 (PMID:16436377)
GO_REF:0000033		 RGD
GO_Central		 PMID:16436377 PMID:7487891 GO_REF:0000033, RGD:1599112 NCBI chr 2:232,545,550...232,547,098 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta enables
contributes_to		 IDA
IEA
ISS
ISO
IBA		 GO_REF:0000003
GO_REF:0000116
GO_REF:0000104
GO_REF:0000024
(PMID:19081061)
GO_REF:0000033		 UniProt
RHEA
RGD
GO_Central		 PMID:19081061 PMID:7487891 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:1599112 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      oxidoreductase activity 869
        oxidoreductase activity, acting on the aldehyde or oxo group of donors 92
          oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 9
            pyruvate dehydrogenase (acetyl-transferring) activity 4
paths to the root