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ONTOLOGY REPORT - ANNOTATIONS


Term:protein tyrosine phosphatase activity
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Accession:GO:0004725 term browser browse the term
Definition:Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Synonyms:exact_synonym: PPT-phosphatase activity;   PTP-phosphatase activity;   PTPase activity;   phosphoprotein phosphatase (phosphotyrosine) activity;   phosphotyrosine histone phosphatase activity;   phosphotyrosine phosphatase activity;   phosphotyrosine protein phosphatase activity;   phosphotyrosylprotein phosphatase activity;   protein-tyrosine-phosphate phosphohydrolase activity;   tyrosine O-phosphate phosphatase activity;   tyrosylprotein phosphatase activity
 xref: EC:3.1.3.48;   MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN;   reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2";   reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR";   reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2";   reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2";   reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45";   reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)";   reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1";   reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases";   reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn";   reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)";   reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX";   reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET";   reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET";   reactome:R-HSA-74733 "Insulin receptor de-phosphorylation";   reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2";   reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1";   reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs";   reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6";   reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22";   reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70";   reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248";   reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)";   reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021";   reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248";   reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15";   reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1";   reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB";   reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3";   reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2";   reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B";   reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1";   reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP"


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protein tyrosine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp1 acid phosphatase 1 JBrowse link 6 49,836,064 49,851,714 RGD:1598713
RGD:13792537
G Acp4 acid phosphatase 4 JBrowse link 1 100,226,311 100,234,536 RGD:1600115
RGD:1624291
G Cdc14a cell division cycle 14A JBrowse link 2 219,302,577 219,458,345 RGD:13792537
G Cdc14b cell division cycle 14B JBrowse link 17 1,709,703 1,797,732 RGD:1624291
RGD:13792537
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:1600115
RGD:13792537
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:1600115
RGD:13792537
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:13792537
G Cdkn3 cyclin-dependent kinase inhibitor 3 JBrowse link 15 23,553,171 23,564,538 RGD:1624291
RGD:13792537
G Dupd1 dual specificity phosphatase and pro isomerase domain containing 1 JBrowse link 15 2,766,929 2,806,573 RGD:1600115
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1600115
RGD:1624291
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1600115
G Dusp11 dual specificity phosphatase 11 JBrowse link 4 117,617,640 117,631,674 RGD:1624291
RGD:1600115
G Dusp12 dual specificity phosphatase 12 JBrowse link 13 89,258,309 89,267,402 RGD:1600115
G Dusp13 dual specificity phosphatase 13 JBrowse link 15 2,524,435 2,541,734 RGD:1600115
G Dusp14 dual specificity phosphatase 14 JBrowse link 10 71,363,688 71,383,602 RGD:1600115
G Dusp14l1 dual specificity phosphatase 14-like 1 JBrowse link 2 140,835,793 140,837,188 RGD:1600115
G Dusp15 dual specificity phosphatase 15 JBrowse link 3 148,417,990 148,428,494 RGD:1624291
RGD:1600115
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:1600115
G Dusp18 dual specificity phosphatase 18 JBrowse link 14 84,150,484 84,169,645 RGD:1600115
RGD:1624291
G Dusp2 dual specificity phosphatase 2 JBrowse link 3 119,776,925 119,779,110 RGD:1600115
G Dusp21 dual specificity phosphatase 21 JBrowse link X 4,956,699 4,957,555 RGD:1624291
RGD:1600115
G Dusp22 dual specificity phosphatase 22 JBrowse link 17 34,986,589 35,037,297 RGD:1624291
G Dusp23 dual specificity phosphatase 23 JBrowse link 13 91,018,670 91,019,862 RGD:13792537
G Dusp26 dual specificity phosphatase 26 JBrowse link 16 64,798,782 64,806,459 RGD:1624291
RGD:1600115
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1600115
RGD:1624291
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:1600115
RGD:1624291
G Dusp5 dual specificity phosphatase 5 JBrowse link 1 274,245,184 274,258,595 RGD:1600115
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:1600115
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:1600115
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:1600115
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:1600115
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
RGD:13792537
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
G Eya2 EYA transcriptional coactivator and phosphatase 2 JBrowse link 3 162,285,275 162,470,642 RGD:1624291
RGD:13792537
G Eya3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 5 150,833,754 150,915,390 RGD:1624291
RGD:13792537
G Eya4 EYA transcriptional coactivator and phosphatase 4 JBrowse link 1 23,237,617 23,611,580 RGD:13792537
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 JBrowse link 11 68,893,684 68,985,635 RGD:1624291
G LOC100365697 protein tyrosine phosphatase 4a1-like RGD:13792537
G LOC103690006 RNA/RNP complex-1-interacting phosphatase JBrowse link 4 117,797,735 117,814,732 RGD:1600115
G LOC103693189 protein tyrosine phosphatase type IVA 1 JBrowse link 9 3,895,820 3,900,891 RGD:13792537
G LOC108348179 dual specificity protein phosphatase 13 JBrowse link 15 2,732,886 2,738,561 RGD:1600115
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1600115
G Mtmr1 myotubularin related protein 1 JBrowse link 18 291,785 325,415 RGD:1600115
G Mtmr14 myotubularin related protein 14 JBrowse link 4 145,195,046 145,238,097 RGD:1600115
G Mtmr2 myotubularin related protein 2 JBrowse link 8 12,283,471 12,334,014 RGD:1600115
G Mtmr3 myotubularin related protein 3 JBrowse link 14 84,701,559 84,820,487 RGD:1600115
RGD:1624291
G Mtmr4 myotubularin related protein 4 JBrowse link 10 74,886,600 74,909,532 RGD:1600115
G Mtmr6 myotubularin related protein 6 JBrowse link 15 40,558,917 40,597,311 RGD:1600115
G Mtmr7 myotubularin related protein 7 JBrowse link 16 54,765,214 54,856,255 RGD:1600115
G Pald1 phosphatase domain containing, paladin 1 JBrowse link 20 30,938,901 30,983,907 RGD:13792537
G Pgp phosphoglycolate phosphatase JBrowse link 10 13,836,105 13,838,731 RGD:1624291
RGD:1600115
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G Ptp4a1 protein tyrosine phosphatase 4A1 JBrowse link 9 37,223,363 37,254,222 RGD:61722
RGD:13792537
G Ptp4a2 protein tyrosine phosphatase 4A2 JBrowse link 5 148,035,501 148,060,752 RGD:13792537
G Ptp4a3 protein tyrosine phosphatase 4A3 JBrowse link 7 114,969,699 115,002,902 RGD:13792537
G Ptpdc1 protein tyrosine phosphatase domain containing 1 JBrowse link 17 16,333,369 16,381,887 RGD:13792537
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 JBrowse link 3 79,734,961 79,743,737 RGD:1600115
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:2289367
RGD:1624291
RGD:2293185
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:729786
RGD:1624291
RGD:2293185
RGD:1601573
RGD:1581313
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 JBrowse link 4 10,631,129 10,702,390 RGD:633766
RGD:1624291
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 JBrowse link 14 7,688,551 7,863,664 RGD:1624291
RGD:1600115
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 JBrowse link 13 108,689,916 108,841,593 RGD:1624291
RGD:1600115
G Ptpn18 protein tyrosine phosphatase, non-receptor type 18 JBrowse link 9 40,972,089 40,988,790 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Ptpn20 protein tyrosine phosphatase, non-receptor type 20 JBrowse link 16 9,907,584 9,973,514 RGD:1600115
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 JBrowse link 6 122,656,500 122,721,496 RGD:633837
RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1600115
RGD:1624291
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 JBrowse link 8 118,628,777 118,651,238 RGD:1624291
RGD:1600115
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 JBrowse link 5 74,248,996 74,368,167 RGD:1624291
RGD:1600115
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:1624291
RGD:1600115
RGD:9835004
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1302222
RGD:1624291
RGD:1600115
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 JBrowse link 13 51,958,023 51,971,431 RGD:13792537
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 JBrowse link 8 61,658,851 61,739,458 RGD:708311
RGD:13792537
RGD:1600115
RGD:1624291
G Ptpra protein tyrosine phosphatase, receptor type, A JBrowse link 3 122,976,066 123,084,585 RGD:2314625
RGD:13792537
RGD:1600115
G Ptprb protein tyrosine phosphatase, receptor type, B JBrowse link 7 59,326,484 59,431,114 RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:13792537
RGD:1358565
RGD:1600115
G Ptprd protein tyrosine phosphatase, receptor type, D JBrowse link 5 92,862,229 93,514,071 RGD:13792537
G Ptpre protein tyrosine phosphatase, receptor type, E JBrowse link 1 207,820,719 207,987,123 RGD:633852
RGD:13792537
RGD:1624291
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:69951
RGD:13792537
RGD:1600115
RGD:1624291
G Ptprg protein tyrosine phosphatase, receptor type, G JBrowse link 15 12,926,056 13,633,839 RGD:633859
RGD:13792537
RGD:1624291
G Ptprh protein tyrosine phosphatase, receptor type, H JBrowse link 1 72,809,935 72,859,161 RGD:13792537
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
RGD:13792537
G Ptprk protein tyrosine phosphatase, receptor type, K JBrowse link 1 17,445,052 18,058,266 RGD:634006
RGD:13792537
RGD:1624291
G Ptprm protein tyrosine phosphatase, receptor type, M JBrowse link 9 114,846,095 115,555,261 RGD:1624291
RGD:13792537
G Ptprn protein tyrosine phosphatase, receptor type, N JBrowse link 9 82,446,626 82,462,314 RGD:1624291
RGD:1600115
G Ptprn2 protein tyrosine phosphatase, receptor type N2 JBrowse link 6 144,384,773 145,133,042 RGD:1600115
G Ptpro protein tyrosine phosphatase, receptor type, O JBrowse link 4 171,250,766 171,461,571 RGD:61725
RGD:1624291
RGD:1600115
G Ptprq protein tyrosine phosphatase, receptor type, Q JBrowse link 7 49,763,657 50,034,932 RGD:1600115
G Ptprr protein tyrosine phosphatase, receptor type, R JBrowse link 7 59,039,717 59,325,925 RGD:729713
RGD:1600115
RGD:1624291
G Ptprs protein tyrosine phosphatase, receptor type, S JBrowse link 9 10,585,360 10,646,205 RGD:69951
RGD:13792537
RGD:1600115
RGD:1624291
G Ptprt protein tyrosine phosphatase, receptor type, T JBrowse link 3 157,537,192 158,328,984 RGD:1624291
RGD:13792537
G Ptpru protein tyrosine phosphatase, receptor type, U JBrowse link 5 149,922,374 149,996,352 RGD:1624291
RGD:13792537
G Ptprv protein tyrosine phosphatase, receptor type, V JBrowse link 13 51,935,239 51,956,262 RGD:1600115
RGD:13792537
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 JBrowse link 4 49,941,046 50,140,764 RGD:9589125
RGD:13792537
RGD:1624291
RGD:1600115
RGD:11344935
RGD:9590130
G Rngtt RNA guanylyltransferase and 5'-phosphatase JBrowse link 5 48,561,325 48,779,214 RGD:1600115
G Ssh1 slingshot protein phosphatase 1 JBrowse link 12 48,403,184 48,447,964 RGD:1600115
G Ssh2 slingshot protein phosphatase 2 JBrowse link 10 62,702,286 62,954,907 RGD:1600115
G Ssh3 slingshot protein phosphatase 3 JBrowse link 1 219,511,908 219,519,398 RGD:1600115
G Timm50 translocase of inner mitochondrial membrane 50 JBrowse link 1 85,470,810 85,480,813 RGD:1624291
RGD:1600115
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 JBrowse link 16 74,552,859 74,662,194 RGD:1600115
G Ubash3b ubiquitin associated and SH3 domain containing, B JBrowse link 8 45,224,053 45,375,450 RGD:1624291
RGD:13792537
non-membrane spanning protein tyrosine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp1 acid phosphatase 1 JBrowse link 6 49,836,064 49,851,714 RGD:1600115
G Dusp22 dual specificity phosphatase 22 JBrowse link 17 34,986,589 35,037,297 RGD:1600115
RGD:1624291
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1624291
RGD:1600115
G Ptpn18 protein tyrosine phosphatase, non-receptor type 18 JBrowse link 9 40,972,089 40,988,790 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:729799
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 JBrowse link 13 35,678,240 35,858,414 RGD:1624291
RGD:1600115
transmembrane receptor protein tyrosine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1600115
RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1358565
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:2293185
G Ptprh protein tyrosine phosphatase, receptor type, H JBrowse link 1 72,809,935 72,859,161 RGD:1600115
G Ptprm protein tyrosine phosphatase, receptor type, M JBrowse link 9 114,846,095 115,555,261 RGD:1624291
RGD:1600115
G Ptprt protein tyrosine phosphatase, receptor type, T JBrowse link 3 157,537,192 158,328,984 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18245
    catalytic activity 5761
      catalytic activity, acting on a protein 2193
        phosphoprotein phosphatase activity 177
          protein tyrosine phosphatase activity 102
            MAP kinase tyrosine phosphatase activity 0
            non-membrane spanning protein tyrosine phosphatase activity 6
            prenylated protein tyrosine phosphatase activity 0
            protein tyrosine phosphatase activity, metal-dependent 0
            protein tyrosine phosphatase activity, via thiol-phosphate intermediate 0
            transmembrane receptor protein tyrosine phosphatase activity 6
Path 2
Term Annotations click to browse term
  molecular_function 18245
    catalytic activity 5761
      hydrolase activity 2499
        hydrolase activity, acting on ester bonds 765
          phosphoric ester hydrolase activity 370
            phosphatase activity 275
              phosphoprotein phosphatase activity 177
                protein tyrosine phosphatase activity 102
                  MAP kinase tyrosine phosphatase activity 0
                  non-membrane spanning protein tyrosine phosphatase activity 6
                  prenylated protein tyrosine phosphatase activity 0
                  protein tyrosine phosphatase activity, metal-dependent 0
                  protein tyrosine phosphatase activity, via thiol-phosphate intermediate 0
                  transmembrane receptor protein tyrosine phosphatase activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.