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ONTOLOGY REPORT - ANNOTATIONS


Term:protein serine/threonine phosphatase activity
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Accession:GO:0004722 term browser browse the term
Definition:Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
Synonyms:exact_synonym: serine/threonine specific protein phosphatase activity
 narrow_synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase;   Aspergillus awamori acid protein phosphatase;   BCKDH phosphatase;   HMG-CoA reductase phosphatase;   branched-chain alpha-keto acid dehydrogenase phosphatase;   calcineurin;   casein phosphatase;   phosphatase 2A;   phosphatase 2B;   phosphatase C-II;   phosphatase H-II;   phosphatase I;   phosphatase IB;   phosphatase II;   phosphatase III;   phosphatase IV;   phosphatase SP;   phosphopyruvate dehydrogenase phosphatase;   phosphospectrin phosphatase;   polycation modulated (PCM-) phosphatase;   protein D phosphatase;   protein phosphatase X;   protein phosphatase type 1 activity;   protein phosphatase type 1, intrinsic catalyst activity;   protein phosphatase type 2A activity;   protein phosphatase type 2A, intrinsic catalyst activity;   protein phosphatase type 2B activity;   protein phosphatase type 2B, intrinsic catalyst activity;   protein phosphatase type 2C activity;   protein phosphatase type 4 activity;   protein phosphatase type 4, intrinsic catalyst activity
 alt_id: GO:0000158;   GO:0000163;   GO:0008598;   GO:0008600;   GO:0015071;   GO:0030357;   GO:0030358;   GO:0030360;   GO:0030361
 xref: reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";   reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";   reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";   reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";   reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";   reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";   reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";   reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";   reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";   reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";   reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";   reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";   reactome:R-HSA-380949 "AMPK is dephosphorylated";   reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";   reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate";   reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";   reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";   reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";   reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";   reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";   reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";   reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";   reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";   reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";   reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH";   reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";   reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";   reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";   reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine";   reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";   reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";   reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";   reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";   reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"


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protein serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC013717.1 novel protein, PPM1B-SLC3A1 readthrough RGD:2290271
G CDC14A cell division cycle 14A JBrowse link 1 100,345,001 100,520,281 RGD:2290271
G CDC14B cell division cycle 14B JBrowse link 9 96,492,743 96,619,843 RGD:2290271
G CDC14C cell division cycle 14C JBrowse link 7 48,924,547 48,927,454 RGD:2290271
G CDKN3 cyclin dependent kinase inhibitor 3 JBrowse link 14 54,396,868 54,420,218 RGD:2290271
G CTDNEP1 CTD nuclear envelope phosphatase 1 JBrowse link 17 7,243,591 7,251,978 RGD:2290271
G CYCS cytochrome c, somatic JBrowse link 7 25,118,656 25,125,260 RGD:2290271
G DUSP1 dual specificity phosphatase 1 JBrowse link 5 172,768,096 172,771,195 RGD:2290271
G EPM2A EPM2A glucan phosphatase, laforin JBrowse link 6 145,382,540 145,736,023 RGD:2290271
G ILKAP ILK associated serine/threonine phosphatase JBrowse link 2 238,170,401 238,203,702 RGD:2290271
G LCK LCK proto-oncogene, Src family tyrosine kinase JBrowse link 1 32,251,265 32,286,167 RGD:2290271
G LRRC2 leucine rich repeat containing 2 JBrowse link 3 46,515,385 46,580,099 RGD:2290271
G LRRC30 leucine rich repeat containing 30 JBrowse link 18 7,231,104 7,232,088 RGD:2290271
G LRRC39 leucine rich repeat containing 39 JBrowse link 1 100,148,448 100,178,273 RGD:2290271
G LRRC40 leucine rich repeat containing 40 JBrowse link 1 70,144,805 70,205,676 RGD:2290271
G LRRIQ4 leucine rich repeats and IQ motif containing 4 JBrowse link 3 169,812,947 169,838,007 RGD:2290271
G LRRK1 leucine rich repeat kinase 1 JBrowse link 15 100,919,017 101,078,257 RGD:2290271
G LRRK2 leucine rich repeat kinase 2 JBrowse link 12 40,224,890 40,369,285 RGD:2290271
G MTMR3 myotubularin related protein 3 JBrowse link 22 29,883,169 30,030,868 RGD:2290271
G MTMR4 myotubularin related protein 4 JBrowse link 17 58,489,537 58,518,109 RGD:2290271
G MTMR6 myotubularin related protein 6 JBrowse link 13 25,246,201 25,287,512 RGD:2290271
G PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 JBrowse link 8 93,916,923 93,926,068 RGD:2290271
G PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 JBrowse link 16 66,880,515 66,891,101 RGD:2290271
G PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase JBrowse link 12 132,710,842 132,722,734 RGD:2290271
G PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 18 62,715,445 62,980,433 RGD:2290271
G PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 16 71,644,924 71,724,701 RGD:2290271
G PP2D1 protein phosphatase 2C like domain containing 1 JBrowse link 3 19,979,961 20,012,264 RGD:2290271
G PPA2 inorganic pyrophosphatase 2 JBrowse link 4 105,369,077 105,474,070 RGD:2290271
G PPEF1 protein phosphatase with EF-hand domain 1 JBrowse link X 18,675,067 18,827,921 RGD:2290271
G PPEF2 protein phosphatase with EF-hand domain 2 JBrowse link 4 75,859,867 75,902,452 RGD:2290271
G PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A JBrowse link 14 60,245,750 60,299,087 RGD:2290271
G PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B JBrowse link 2 44,168,803 44,247,330 RGD:2290271
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 17 60,600,187 60,666,280 RGD:2290271
G PPM1E protein phosphatase, Mg2+/Mn2+ dependent 1E JBrowse link 17 58,755,854 58,985,617 RGD:2290271
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F JBrowse link 22 21,919,419 21,952,875 RGD:2290271
G PPM1G protein phosphatase, Mg2+/Mn2+ dependent 1G JBrowse link 2 27,381,199 27,409,591 RGD:2290271
G PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H JBrowse link 12 62,643,992 62,935,150 RGD:2290271
G PPM1J protein phosphatase, Mg2+/Mn2+ dependent 1J JBrowse link 1 112,709,994 112,715,328 RGD:2290271
G PPM1K protein phosphatase, Mg2+/Mn2+ dependent 1K JBrowse link 4 88,257,617 88,284,670 RGD:2290271
G PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L JBrowse link 3 160,755,532 161,078,907 RGD:2290271
G PPM1M protein phosphatase, Mg2+/Mn2+ dependent 1M JBrowse link 3 52,245,725 52,250,599 RGD:2290271
G PPM1N protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) JBrowse link 19 45,497,964 45,502,694 RGD:2290271
G PPP1CA protein phosphatase 1 catalytic subunit alpha JBrowse link 11 67,398,183 67,401,858 RGD:2290271
G PPP1CB protein phosphatase 1 catalytic subunit beta JBrowse link 2 28,751,748 28,802,940 RGD:2290271
G PPP1CC protein phosphatase 1 catalytic subunit gamma JBrowse link 12 110,708,369 110,742,914 RGD:2290271
G PPP1R3C protein phosphatase 1 regulatory subunit 3C JBrowse link 10 91,628,442 91,633,071 RGD:2290271
G PPP1R3D protein phosphatase 1 regulatory subunit 3D JBrowse link 20 59,936,663 59,940,305 RGD:2290271
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 5 134,194,332 134,226,073 RGD:2290271
G PPP2CB protein phosphatase 2 catalytic subunit beta JBrowse link 8 30,785,616 30,812,818 RGD:2290271
G PPP2R1A protein phosphatase 2 scaffold subunit Aalpha JBrowse link 19 52,190,052 52,229,518 RGD:2290271
RGD:9068941
G PPP2R1B protein phosphatase 2 scaffold subunit Abeta JBrowse link 11 111,690,273 111,766,389 RGD:2290271
G PPP3CA protein phosphatase 3 catalytic subunit alpha JBrowse link 4 101,023,418 101,348,295 RGD:2290271
G PPP3CB protein phosphatase 3 catalytic subunit beta JBrowse link 10 73,436,428 73,496,024 RGD:2290271
G PPP4C protein phosphatase 4 catalytic subunit JBrowse link 16 30,075,994 30,085,377 RGD:2290271
G PPP4R1 protein phosphatase 4 regulatory subunit 1 JBrowse link 18 9,546,794 9,615,273 RGD:2290271
G PPP4R1L protein phosphatase 4 regulatory subunit 1 like (pseudogene) JBrowse link 20 58,232,777 58,309,439 RGD:2290271
G PPP5C protein phosphatase 5 catalytic subunit JBrowse link 19 46,347,069 46,390,975 RGD:2290271
G PPP6C protein phosphatase 6 catalytic subunit JBrowse link 9 125,146,573 125,189,939 RGD:2290271
G PPTC7 protein phosphatase targeting COQ7 JBrowse link 12 110,533,245 110,583,318 RGD:2290271
G PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:2290271
G RPAP2 RNA polymerase II associated protein 2 JBrowse link 1 92,299,050 92,402,056 RGD:2290271
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link 22 39,399,780 39,437,132 RGD:2290271
G TIMM50 translocase of inner mitochondrial membrane 50 JBrowse link 19 39,480,838 39,493,779 RGD:2290271
G UBLCP1 ubiquitin like domain containing CTD phosphatase 1 JBrowse link 5 159,263,290 159,286,036 RGD:2290271
calcium-dependent protein serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CAMK2G calcium/calmodulin dependent protein kinase II gamma JBrowse link 10 73,812,501 73,874,591 RGD:2290271
G PPP2R3B protein phosphatase 2 regulatory subunit B''beta JBrowse link X
Y
333,933
333,933
387,327
387,327
RGD:9068941
G PPP3CA protein phosphatase 3 catalytic subunit alpha JBrowse link 4 101,023,418 101,348,295 RGD:9068941
G PPP3CB protein phosphatase 3 catalytic subunit beta JBrowse link 10 73,436,428 73,496,024 RGD:9068941
G PPP3R1 protein phosphatase 3 regulatory subunit B, alpha JBrowse link 2 68,178,857 68,252,532 RGD:2290271
calmodulin-dependent protein phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A JBrowse link 14 60,245,750 60,299,087 RGD:2290271
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F JBrowse link 22 21,919,419 21,952,875 RGD:2290271
G PPP3CA protein phosphatase 3 catalytic subunit alpha JBrowse link 4 101,023,418 101,348,295 RGD:2290271
G PPP3CB protein phosphatase 3 catalytic subunit beta JBrowse link 10 73,436,428 73,496,024 RGD:2290271
G PPP3CC protein phosphatase 3 catalytic subunit gamma JBrowse link 8 22,440,970 22,541,466 RGD:2290271
magnesium-dependent protein serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ILKAP ILK associated serine/threonine phosphatase JBrowse link 2 238,170,401 238,203,702 RGD:2290271
G PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 JBrowse link 8 93,916,923 93,926,068 RGD:2290271
G PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 JBrowse link 16 66,880,515 66,891,101 RGD:2290271
G PP2D1 protein phosphatase 2C like domain containing 1 JBrowse link 3 19,979,961 20,012,264 RGD:2290271
G PPM1E protein phosphatase, Mg2+/Mn2+ dependent 1E JBrowse link 17 58,755,854 58,985,617 RGD:2290271
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F JBrowse link 22 21,919,419 21,952,875 RGD:2290271
G PPM1G protein phosphatase, Mg2+/Mn2+ dependent 1G JBrowse link 2 27,381,199 27,409,591 RGD:2290271
G PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H JBrowse link 12 62,643,992 62,935,150 RGD:2290271
G PPM1J protein phosphatase, Mg2+/Mn2+ dependent 1J JBrowse link 1 112,709,994 112,715,328 RGD:2290271
G PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L JBrowse link 3 160,755,532 161,078,907 RGD:2290271
G PPM1M protein phosphatase, Mg2+/Mn2+ dependent 1M JBrowse link 3 52,245,725 52,250,599 RGD:2290271
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link 22 39,399,780 39,437,132 RGD:2290271
MAP kinase serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DUSP4 dual specificity phosphatase 4 JBrowse link 8 29,333,062 29,350,684 RGD:2290271
myosin phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MYH3 myosin heavy chain 3 JBrowse link 17 10,628,527 10,678,347 RGD:2290271
G MYH6 myosin heavy chain 6 JBrowse link 14 23,381,987 23,408,273 RGD:2290271
G MYH8 myosin heavy chain 8 JBrowse link 17 10,390,322 10,421,950 RGD:2290271
G PPP1CB protein phosphatase 1 catalytic subunit beta JBrowse link 2 28,751,748 28,802,940 RGD:2290271
RNA polymerase II CTD heptapeptide repeat phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CTDP1 CTD phosphatase subunit 1 JBrowse link 18 79,679,803 79,756,625 RGD:2290271
G CTDSP1 CTD small phosphatase 1 JBrowse link 2 218,398,233 218,405,941 RGD:2290271
G CTDSP2 CTD small phosphatase 2 JBrowse link 12 57,816,702 57,846,729 RGD:2290271
G CTDSPL CTD small phosphatase like JBrowse link 3 37,861,880 37,984,469 RGD:2290271
G CTDSPL2 CTD small phosphatase like 2 JBrowse link 15 44,427,329 44,529,038 RGD:2290271
G RPAP2 RNA polymerase II associated protein 2 JBrowse link 1 92,299,050 92,402,056 RGD:2290271
G SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase JBrowse link 1 1,541,673 1,574,863 RGD:2290271
G SSU72P2 SSU72 pseudogene 2 JBrowse link 11 4,242,056 4,242,650 RGD:2290271
G SSU72P3 SSU72 pseudogene 3 JBrowse link 11 4,329,864 4,330,449 RGD:2290271
G SSU72P4 SSU72 pseudogene 4 JBrowse link 11 4,287,499 4,288,093 RGD:2290271
G SSU72P5 SSU72 pseudogene 5 JBrowse link 11 4,233,278 4,233,872 RGD:2290271
G SSU72P7 SSU72 pseudogene 7 JBrowse link 11 4,338,660 4,339,244 RGD:2290271
G SSU72P8 SSU72 pseudogene 8 JBrowse link 7 124,476,371 124,476,955 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18725
    catalytic activity 5978
      catalytic activity, acting on a protein 2324
        phosphoprotein phosphatase activity 192
          protein serine/threonine phosphatase activity 84
            MAP kinase serine/threonine phosphatase activity 1
            RNA polymerase II CTD heptapeptide repeat phosphatase activity 13
            calcium-dependent protein serine/threonine phosphatase activity + 8
            magnesium-dependent protein serine/threonine phosphatase activity 12
            myosin phosphatase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 18725
    catalytic activity 5978
      hydrolase activity 2630
        hydrolase activity, acting on ester bonds 808
          phosphoric ester hydrolase activity 394
            phosphatase activity 296
              phosphoprotein phosphatase activity 192
                protein serine/threonine phosphatase activity 84
                  MAP kinase serine/threonine phosphatase activity 1
                  RNA polymerase II CTD heptapeptide repeat phosphatase activity 13
                  calcium-dependent protein serine/threonine phosphatase activity + 8
                  magnesium-dependent protein serine/threonine phosphatase activity 12
                  myosin phosphatase activity 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.