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ONTOLOGY REPORT - ANNOTATIONS


Term:protein serine/threonine phosphatase activity
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Accession:GO:0004722 term browser browse the term
Definition:Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
Synonyms:exact_synonym: serine/threonine specific protein phosphatase activity
 narrow_synonym: phosphatase I;   phosphatase II;   phosphatase III;   protein phosphatase type 1 activity;   protein phosphatase type 2A activity;   protein phosphatase type 2B activity;   protein phosphatase type 2C activity;   protein phosphatase-1;   protein phosphatase-2A;   protein phosphatase-2B;   protein phosphatase-2C;   protein serine phosphatase activity;   protein threonine phosphatase activity
 related_synonym: magnesium-dependent protein serine/threonine phosphatase activity
 alt_id: GO:0000158;   GO:0000163;   GO:0004724;   GO:0008598;   GO:0008600;   GO:0015071;   GO:0030357;   GO:0030358;   GO:0030360;   GO:0030361;   GO:0106306;   GO:0106307
 xref: EC:3.1.3.16;   Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs";   Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex";   Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs";   Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2";   reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";   reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";   reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";   reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";   reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";   reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";   reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";   reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";   reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";   reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";   reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";   reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";   reactome:R-HSA-380949 "AMPK is dephosphorylated";   reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";   reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate";   reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";   reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";   reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";   reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";   reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";   reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";   reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";   reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";   reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";   reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH";   reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";   reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";   reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";   reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";   reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";   reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";   reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";   reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"



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protein serine/threonine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc14a cell division cycle 14A enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927
JBrowse link
G Cdc14b cell division cycle 14B enables IBA
ISO
PMID:21873635
(PMID:18662541), (PMID:9367992)
RGD PMID:9367992 PMID:18662541 PMID:21873635 RGD:13792537 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 enables ISO (PMID:12745075) RGD PMID:12745075 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Ctdnep1 CTD nuclear envelope phosphatase 1 enables ISO
IBA
ISS
(PMID:17420445)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:17420445 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:54,704,367...54,713,781
Ensembl chr10:54,704,148...54,713,781
JBrowse link
G Dusp1 dual specificity phosphatase 1 enables ISS
ISO
GO_REF:0000024
(MGI:62859|PMID:8355678)
UniProt
RGD
PMID:8355678 GO_REF:0000024 MGI:62859 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin enables ISO (PMID:12915448)
(MGI:3695866|PMID:16971387)
RGD PMID:12915448 PMID:16971387 MGI:3695866 NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase enables IDA
IEA
GO_REF:0000002 InterPro
RGD
PMID:9857069 GO_REF:0000002, RGD:632254 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase enables ISO
IEA
(PMID:8506364)
GO_REF:0000107
RGD
Ensembl
PMID:8506364 GO_REF:0000107 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G LOC100362453 serine/threonine-protein phosphatase 2A catalytic subunit alpha-like enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:82,278,288...82,280,159
Ensembl chr11:82,278,292...82,280,174
JBrowse link
G Lrrc2 leucine rich repeat containing 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185
JBrowse link
G Lrrc30 leucine rich repeat containing 30 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:107,624,479...107,626,551
Ensembl chr 9:107,625,182...107,626,084
JBrowse link
G Lrrc39 leucine rich repeat containing 39 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:204,516,122...204,535,463
Ensembl chr 2:204,516,123...204,535,463
JBrowse link
G Lrrc40 leucine rich repeat containing 40 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:247,101,484...247,131,061
Ensembl chr 2:247,101,500...247,131,059
JBrowse link
G Lrriq4 leucine-rich repeats and IQ motif containing 4 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:112,729,298...112,756,338
Ensembl chr 2:112,729,417...112,753,234
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mtmr3 myotubularin related protein 3 enables ISO
IEA
(PMID:10733931)
GO_REF:0000107
RGD
Ensembl
PMID:10733931 GO_REF:0000107 NCBI chr14:79,340,523...79,460,947
Ensembl chr14:79,340,513...79,461,041
JBrowse link
G Mtmr4 myotubularin related protein 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:72,393,411...72,416,342
Ensembl chr10:72,392,551...72,416,342
JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 enables IMP
IEA
ISO
GO_REF:0000002
GO_REF:0000107
(PMID:20801214)
InterPro
Ensembl
RGD
PMID:20801214 PMID:15210124 GO_REF:0000002 GO_REF:0000107, RGD:1642641 NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217
JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 enables IDA
IEA
PMID:20801214
GO_REF:0000002
InterPro PMID:20801214 GO_REF:0000002, RGD:7794756 NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase enables IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:19590015)
Ensembl
RGD
PMID:19590015 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 enables IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:20089132 PMID:21873635 RGD:5131540, RGD:13792537 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 enables IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:20089132 PMID:21873635 RGD:5131540, RGD:13792537 NCBI chr19:37,835,125...37,901,804
Ensembl chr19:37,835,125...37,905,513
JBrowse link
G Pp2d1 protein phosphatase 2C-like domain containing 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:6,512,282...6,533,653
Ensembl chr 9:6,512,657...6,533,639
JBrowse link
G Ppa2 inorganic pyrophosphatase 2 enables ISO (MGI:3589325|PMID:16129705) RGD PMID:16129705 MGI:3589325 NCBI chr 2:221,800,791...221,878,079
Ensembl chr 2:221,800,842...221,878,081
JBrowse link
G Ppef1 protein phosphatase with EF-hand domain 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:33,994,503...34,151,704
Ensembl chr  X:34,021,350...34,151,701
JBrowse link
G Ppef2 protein phosphatase with EF-hand domain 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:15,797,435...15,831,614
Ensembl chr14:15,797,435...15,831,491
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A enables ISO
IBA
(PMID:10644691), (PMID:11559703), (PMID:20801214)
PMID:21873635
RGD PMID:10644691 PMID:11559703 PMID:20801214 PMID:21873635 RGD:13792537 NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B enables ISO
IBA
(PMID:20801214)
PMID:21873635
RGD PMID:20801214 PMID:21873635 RGD:13792537 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D enables ISO
IBA
(PMID:20801214)
PMID:21873635
RGD PMID:20801214 PMID:21873635 RGD:13792537 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E enables IDA
TAS
ISO
Reactome:R-RNO-9619441
PMID:11726284
(PMID:20801214)
Reactome
RGD
PMID:20801214 PMID:12807427 PMID:11726284 Reactome:R-RNO-9619441, RGD:1299619, RGD:8553885 NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282
JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F enables IDA
IEA
TAS
ISO
ISS
GO_REF:0000002
Reactome:R-RNO-9619459
Reactome:R-RNO-9619472
(PMID:11559703), (PMID:11864573), (PMID:15140879), (PMID:20016286), (PMID:20801214)
GO_REF:0000024
InterPro
Reactome
RGD
UniProt
PMID:11559703 PMID:11864573 PMID:15140879 PMID:20016286 PMID:20801214 More... GO_REF:0000002 GO_REF:0000024 Reactome:R-RNO-9619459 Reactome:R-RNO-9619472, RGD:7241145 NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340
JBrowse link
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G enables ISO
IEA
(PMID:20801214)
GO_REF:0000107
RGD
Ensembl
PMID:20801214 GO_REF:0000107 NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761
JBrowse link
G Ppm1h protein phosphatase, Mg2+/Mn2+ dependent, 1H enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:58,338,661...58,599,547
Ensembl chr 7:58,338,661...58,599,547
JBrowse link
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J enables IEA
ISO
GO_REF:0000107
GO_REF:0000002
(MGI:2651995|PMID:12633878)
Ensembl
InterPro
RGD
PMID:12633878 GO_REF:0000002 GO_REF:0000107 MGI:2651995 NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
JBrowse link
G Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L enables ISO (MGI:2668070|PMID:12556533) RGD PMID:12556533 MGI:2668070 NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434
JBrowse link
G Ppm1m protein phosphatase, Mg2+/Mn2+ dependent, 1M enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:106,836,221...106,843,472
Ensembl chr 8:106,837,037...106,842,057
JBrowse link
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:78,929,350...78,934,435
Ensembl chr 1:78,929,351...78,932,685
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha enables IBA
TAS
ISO
PMID:21873635
Reactome:R-RNO-163609
(MGI:2183839|PMID:12115603), (MGI:3028820|PMID:14640981)
Reactome
RGD
PMID:12115603 PMID:14640981 PMID:21873635 MGI:2183839 MGI:3028820 Reactome:R-RNO-163609, RGD:13792537 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta enables IBA
TAS
ISO
PMID:21873635
Reactome:R-RNO-163609
(MGI:3028820|PMID:14640981)
Reactome
RGD
PMID:14640981 PMID:21873635 MGI:3028820 Reactome:R-RNO-163609, RGD:13792537 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma enables IBA
IEA
TAS
ISO
ISS
PMID:21873635
GO_REF:0000002
Reactome:R-RNO-163609
(MGI:2671672|PMID:12931191), (MGI:3028820|PMID:14640981), (MGI:3702260|PMID:17369396)
GO_REF:0000024
(PMID:10880350), (PMID:17936702)
InterPro
Reactome
RGD
UniProt
PMID:10880350 PMID:12931191 PMID:14640981 PMID:17369396 PMID:17936702 More... GO_REF:0000002 GO_REF:0000024 MGI:2671672 MGI:3028820 MGI:3702260 Reactome:R-RNO-163609, RGD:13792537 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha enables TAS
IBA
ISO
IMP
IDA
PMID:21873635
(PMID:25438055), (PMID:30513302), (PMID:30595372), (PMID:30611118)
PMID:10640627
RGD PMID:25438055 PMID:30513302 PMID:30595372 PMID:30611118 PMID:2461222 More... RGD:729444, RGD:13792537, RGD:13464259, RGD:8693423, RGD:1582610 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta enables IDA
IBA
IMP
PMID:21873635
PMID:10640627
RGD
GO_Central
ARUK-UCL
PMID:11884620 PMID:21873635 PMID:10640627 PMID:16519540 RGD:729591, RGD:13792537, RGD:13464259, RGD:1582610 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha enables ISO (MGI:2675215|PMID:12944463) RGD PMID:12944463 MGI:2675215 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha enables IDA
TAS
ISO
Reactome:R-RNO-201760
(PMID:30611118)
Reactome
RGD
PMID:30611118 PMID:12135494 Reactome:R-RNO-201760, RGD:729536 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta enables ISO
TAS
(MGI:2177839|PMID:11904392), (MGI:2182491|PMID:12091710)
Reactome:R-RNO-201760
RGD
Reactome
PMID:11904392 PMID:12091710 MGI:2177839 MGI:2182491 Reactome:R-RNO-201760 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ppp4c protein phosphatase 4, catalytic subunit enables ISO
ISS
IBA
(PMID:20154705)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:20154705 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit enables ISS
IBA
ISO
IDA
GO_REF:0000024
PMID:21873635
(PMID:30699359)
PMID:15546861
UniProt
RGD
PMID:30699359 PMID:21873635 PMID:15546861 GO_REF:0000024, RGD:13792537, RGD:13507298 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Ppp6c protein phosphatase 6, catalytic subunit enables IMP
IBA
ISO
PMID:21873635
(MGI:6810700|PMID:32474700)
(PMID:16716191), (PMID:32474700)
RGD PMID:16716191 PMID:32474700 PMID:8077208 PMID:21873635 MGI:6810700, RGD:68293, RGD:13792537 NCBI chr 3:22,929,816...22,962,123
Ensembl chr 3:22,931,577...22,962,113
JBrowse link
G Pptc7 protein phosphatase targeting COQ7 enables ISO (PMID:30267671) RGD PMID:30267671 NCBI chr12:34,249,963...34,288,339
Ensembl chr12:34,249,977...34,288,339
JBrowse link
G Pten phosphatase and tensin homolog enables ISO (PMID:9256433) RGD PMID:9256433 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 enables ISO (PMID:15044455) RGD PMID:15044455 NCBI chr 1:83,574,872...83,582,769
Ensembl chr 1:83,556,757...83,582,793
JBrowse link
G Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 enables IBA
ISO
PMID:21873635
(PMID:21949367)
RGD PMID:21949367 PMID:21873635 RGD:13792537 NCBI chr10:28,945,692...28,961,103
Ensembl chr10:28,945,698...28,960,996
JBrowse link
calcium-dependent protein serine/threonine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta enables ISO (MGI:5828018|PMID:27998980) RGD PMID:27998980 MGI:5828018 NCBI chr14:88,507...95,750
Ensembl chr14:89,176...95,750
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha IDA RGD PMID:12135494 RGD:729536 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta IDA RGD PMID:12135494 RGD:729536 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma enables ISO MGI:5788175 (MGI:5697739|PMID:26429887)
(PMID:26429887)
RGD PMID:26429887 MGI:5697739 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
JBrowse link
calmodulin-dependent protein phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000067514 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr  X:145,949,526...145,951,349 JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A enables ISO
IEA
(PMID:11559703)
GO_REF:0000107
RGD
Ensembl
PMID:11559703 GO_REF:0000107 NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F enables ISO
ISS
(PMID:11559703), (PMID:15140879)
GO_REF:0000024
RGD
UniProt
PMID:11559703 PMID:15140879 GO_REF:0000024 NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha enables ISS
IEA
ISO
IBA
IDA
GO_REF:0000024
GO_REF:0000002
(PMID:18815128), (PMID:19154138), (PMID:23468591), (PMID:30254215)
(MGI:6119999|PMID:26794871)
PMID:21873635
PMID:24018048
UniProt
InterPro
RGD
PMID:18815128 PMID:19154138 PMID:23468591 PMID:26794871 PMID:30254215 More... GO_REF:0000002 GO_REF:0000024 MGI:6119999, RGD:13792537, RGD:13507300 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta enables ISO
IEA
ISS
IBA
(PMID:19154138), (PMID:26794871)
GO_REF:0000002
(MGI:5306323|PMID:11978799)
GO_REF:0000024
PMID:21873635
RGD
InterPro
UniProt
PMID:11978799 PMID:19154138 PMID:26794871 PMID:21873635 GO_REF:0000002 GO_REF:0000024 MGI:5306323, RGD:13792537 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma enables IBA
ISO
PMID:21873635
(PMID:19154138)
RGD PMID:19154138 PMID:21873635 RGD:13792537 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
JBrowse link
MAP kinase serine/threonine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp4 dual specificity phosphatase 4 enables ISS
ISO
GO_REF:0000024
(PMID:7535768)
UniProt
RGD
PMID:7535768 GO_REF:0000024 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
myosin phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc14a cell division cycle 14A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927
JBrowse link
G Cdc14b cell division cycle 14B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
JBrowse link
G Ctdnep1 CTD nuclear envelope phosphatase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:54,704,367...54,713,781
Ensembl chr10:54,704,148...54,713,781
JBrowse link
G Ctdp1 CTD phosphatase subunit 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
JBrowse link
G Ctdsp1 CTD small phosphatase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:75,973,694...75,979,298
Ensembl chr 9:75,973,962...75,979,297
JBrowse link
G Ctdsp2 CTD small phosphatase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:62,805,400...62,825,306
Ensembl chr 7:62,805,658...62,825,302
JBrowse link
G Dusp1 dual specificity phosphatase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp10 dual specificity phosphatase 10 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp12 dual specificity phosphatase 12 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:83,122,192...83,131,800
Ensembl chr13:83,122,193...83,131,285
JBrowse link
G Dusp13 dual specificity phosphatase 13 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:2,559,720...2,575,105
Ensembl chr15:2,533,547...2,575,539
JBrowse link
G Dusp14 dual specificity phosphatase 14 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
JBrowse link
G Dusp14l1 dual specificity phosphatase 14-like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:138,738,130...138,739,538
Ensembl chr 2:138,738,101...138,739,486
JBrowse link
G Dusp15 dual specificity phosphatase 15 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:141,408,495...141,419,137
Ensembl chr 3:141,408,498...141,418,999
JBrowse link
G Dusp16 dual specificity phosphatase 16 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:167,546,780...167,629,949
Ensembl chr 4:167,548,155...167,629,980
JBrowse link
G Dusp18 dual specificity phosphatase 18 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:78,790,183...78,811,576
Ensembl chr14:78,787,505...78,811,576
JBrowse link
G Dusp2 dual specificity phosphatase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
JBrowse link
G Dusp21 dual specificity phosphatase 21 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:4,488,021...4,488,877
Ensembl chr  X:4,488,021...4,488,877
JBrowse link
G Dusp26 dual specificity phosphatase 26 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:61,041,784...61,049,319
Ensembl chr16:61,041,792...61,049,051
JBrowse link
G Dusp29 dual specificity phosphatase 29 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:2,593,473...2,634,019
Ensembl chr15:2,593,578...2,633,503
JBrowse link
G Dusp3 dual specificity phosphatase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G Dusp4 dual specificity phosphatase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp5 dual specificity phosphatase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dusp6 dual specificity phosphatase 6 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dusp7 dual specificity phosphatase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:107,009,369...107,016,404
Ensembl chr 8:107,008,528...107,016,404
JBrowse link
G Dusp8 dual specificity phosphatase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G Dusp9 dual specificity phosphatase 9 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:151,351,897...151,355,822
Ensembl chr  X:151,351,897...151,355,821
JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
JBrowse link
G LOC100362453 serine/threonine-protein phosphatase 2A catalytic subunit alpha-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:82,278,288...82,280,159
Ensembl chr11:82,278,292...82,280,174
JBrowse link
G Pdxp pyridoxal phosphatase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:110,472,515...110,477,963
Ensembl chr 7:110,472,515...110,477,963
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G Ppef1 protein phosphatase with EF-hand domain 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:33,994,503...34,151,704
Ensembl chr  X:34,021,350...34,151,701
JBrowse link
G Ppef2 protein phosphatase with EF-hand domain 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:15,797,435...15,831,614
Ensembl chr14:15,797,435...15,831,491
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
JBrowse link
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282
JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340
JBrowse link
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761
JBrowse link
G Ppm1h protein phosphatase, Mg2+/Mn2+ dependent, 1H enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:58,338,661...58,599,547
Ensembl chr 7:58,338,661...58,599,547
JBrowse link
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882
JBrowse link
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:78,929,350...78,934,435
Ensembl chr 1:78,929,351...78,932,685
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
JBrowse link
G Ppp4c protein phosphatase 4, catalytic subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Ppp6c protein phosphatase 6, catalytic subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:22,929,816...22,962,123
Ensembl chr 3:22,931,577...22,962,113
JBrowse link
G Pptc7 protein phosphatase targeting COQ7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:34,249,963...34,288,339
Ensembl chr12:34,249,977...34,288,339
JBrowse link
G Pten phosphatase and tensin homolog enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427
JBrowse link
G Rpap2 RNA polymerase II associated protein 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350
JBrowse link
G Ssh1 slingshot protein phosphatase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274
JBrowse link
G Ssh2 slingshot protein phosphatase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:62,057,400...62,309,328
Ensembl chr10:62,057,044...62,306,563
JBrowse link
G Ssh3 slingshot protein phosphatase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:201,557,167...201,565,577
Ensembl chr 1:201,557,169...201,564,753
JBrowse link
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752
JBrowse link
G Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:28,945,692...28,961,103
Ensembl chr10:28,945,698...28,960,996
JBrowse link
RNA polymerase II CTD heptapeptide repeat phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctdp1 CTD phosphatase subunit 1 enables ISO
IBA
(PMID:12721286), (PMID:9765293)
PMID:21873635
RGD PMID:9765293 PMID:12721286 PMID:21873635 RGD:13792537 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
JBrowse link
G Ctdsp1 CTD small phosphatase 1 enables IBA
ISO
PMID:21873635
(PMID:12721286)
RGD PMID:12721286 PMID:21873635 RGD:13792537 NCBI chr 9:75,973,694...75,979,298
Ensembl chr 9:75,973,962...75,979,297
JBrowse link
G Ctdsp2 CTD small phosphatase 2 enables ISO
IBA
(PMID:12721286)
PMID:21873635
RGD PMID:12721286 PMID:21873635 RGD:13792537 NCBI chr 7:62,805,400...62,825,306
Ensembl chr 7:62,805,658...62,825,302
JBrowse link
G Ctdspl CTD small phosphatase like enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:118,642,729...118,767,238
Ensembl chr 8:118,642,672...118,767,117
JBrowse link
G Ctdspl2 CTD small phosphatase like 2 enables ISO
IEA
(PMID:26920047)
GO_REF:0000107
RGD
Ensembl
PMID:26920047 GO_REF:0000107 NCBI chr 3:108,914,650...108,970,620
Ensembl chr 3:108,915,280...108,967,227
JBrowse link
G Rpap2 RNA polymerase II associated protein 2 enables ISO
IEA
IBA
ISS
(PMID:22137580)
GO_REF:0000104
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:22137580 PMID:21873635 GO_REF:0000024 GO_REF:0000104, RGD:13792537 NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350
JBrowse link
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase enables ISO
IBA
ISS
(PMID:20861839)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20861839 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20762
    catalytic activity 6067
      catalytic activity, acting on a protein 2439
        phosphoprotein phosphatase activity 172
          protein serine/threonine phosphatase activity 90
            MAP kinase serine/threonine phosphatase activity 1
            RNA polymerase II CTD heptapeptide repeat phosphatase activity 7
            calcium-dependent protein serine/threonine phosphatase activity + 7
            histone serine/threonine phosphatase activity + 0
            myosin phosphatase activity 65
Path 2
Term Annotations click to browse term
  molecular_function 20762
    catalytic activity 6067
      hydrolase activity 2538
        hydrolase activity, acting on ester bonds 828
          phosphoric ester hydrolase activity 377
            phosphatase activity 285
              phosphoprotein phosphatase activity 172
                protein serine/threonine phosphatase activity 90
                  MAP kinase serine/threonine phosphatase activity 1
                  RNA polymerase II CTD heptapeptide repeat phosphatase activity 7
                  calcium-dependent protein serine/threonine phosphatase activity + 7
                  histone serine/threonine phosphatase activity + 0
                  myosin phosphatase activity 65
paths to the root