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ONTOLOGY REPORT - ANNOTATIONS

Term:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
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Accession:GO:0004719 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.
Synonyms:related_synonym: D-aspartyl/L-isoaspartyl methyltransferase activity;   L-aspartyl/L-isoaspartyl protein methyltransferase activity;   L-isoaspartyl protein carboxyl methyltransferase activity;   L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity;   S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity;   protein D-aspartate methyltransferase activity;   protein L-isoaspartate methyltransferase activity;   protein L-isoaspartyl methyltransferase activity;   protein O-methyltransferase (L-isoaspartate);   protein beta-aspartate O-methyltransferase activity;   protein-L-isoaspartate O-methyltransferase activity
 xref: EC:2.1.1.77;   MetaCyc:2.1.1.77-RXN;   RHEA:12705;   reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp"


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protein-L-isoaspartate (D-aspartate) O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 enables IDA
IEA
ISO
IBA		 GO_REF:0000003
(PMID:3167043)
(PMID:12023972)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:3167043 PMID:12023972 PMID:8263531 GO_REF:0000003 GO_REF:0000033, RGD:729481 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201 		JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:12,284,711...12,355,680
Ensembl chr 5:12,284,711...12,354,899 		JBrowse link
G Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:168,960,312...168,979,504
Ensembl chr 3:168,960,305...168,979,497 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21087
    catalytic activity 6127
      catalytic activity, acting on a protein 2508
        protein methyltransferase activity 105
          protein carboxyl O-methyltransferase activity 6
            protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 21087
    catalytic activity 6127
      transferase activity 2447
        transferase activity, transferring one-carbon groups 214
          methyltransferase activity 203
            O-methyltransferase activity 25
              carboxyl-O-methyltransferase activity 6
                protein carboxyl O-methyltransferase activity 6
                  protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 3
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