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ONTOLOGY REPORT - ANNOTATIONS

Term:MAP kinase kinase activity
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Accession:GO:0004708 term browser browse the term
Definition:Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
Synonyms:exact_synonym: ERK activator kinase activity;   MAPK activator activity;   MAPKK activity
 narrow_synonym: MAP kinase kinase 4 activity;   MAP kinase kinase 7 activity
 broad_synonym: MEK activity
 related_synonym: ATP:protein phosphotransferase (MAPKKK-activated) activity;   MAP kinase or ERK kinase activity;   MAP2K;   MAPKK;   MAPKK1;   MEK1;   MEK2;   MKK;   MKK2;   MKK4;   MKK6;   MKK7;   STK27;   mitogen-activated protein kinase kinase activity
 xref: EC:2.7.12.2;   MetaCyc:2.7.12.2-RXN;   Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5";   Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3";   Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR";   reactome:R-HSA-1247960 "Activation of p38 MAPK";   reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK"


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MAP kinase kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase enables ISO (PMID:29433126) RGD PMID:29433126 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 enables TAS
IDA
ISO
IEA
IBA		 (PMID:28166211), (PMID:8388392)
GO_REF:0000117
GO_REF:0000033
(PMID:11841548), (PMID:1411546)		 RGD
UniProt
GO_Central		 PMID:1411546 PMID:8388392 PMID:11841548 PMID:28166211 PMID:9779826 More... GO_REF:0000033 GO_REF:0000117, RGD:70317, RGD:1582177, RGD:2293305, RGD:61657, RGD:2298674 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 enables IDA
ISO
IEA
IBA		 (PMID:8388392)
GO_REF:0000117
GO_REF:0000033
(PMID:8297798)		 RGD
UniProt
GO_Central		 PMID:8297798 PMID:8388392 PMID:8393135 PMID:7611406 GO_REF:0000033 GO_REF:0000117, RGD:61657, RGD:2298674 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 enables ISO
IBA		 (PMID:8622669)
GO_REF:0000033
MGI:1857752 (PMID:10097111), (PMID:10202148), (PMID:8900184)		 RGD
GO_Central		 PMID:8622669 PMID:8900184 PMID:10097111 PMID:10202148 GO_REF:0000033 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA RGD PMID:7768885 RGD:2293351 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 enables IC
IEA
IBA
ISO		 GO_REF:0000118
GO_REF:0000033
(PMID:19654213)		 TreeGrafter
GO_Central
RGD		 PMID:19654213 PMID:7499418 GO_REF:0000033 GO_REF:0000118, RGD:61658 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 enables IDA
ISO
IBA		 (PMID:11460167), (PMID:8663074), (PMID:8663524), (PMID:9218798)
GO_REF:0000033
(PMID:20551513)		 RGD
GO_Central		 PMID:8663074 PMID:8663524 PMID:9218798 PMID:11460167 PMID:20551513 More... GO_REF:0000033, RGD:7243113 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 enables IDA
IEA
ISO		 GO_REF:0000117
(PMID:9535930)
PMID:10051439		 UniProt
RGD		 PMID:9535930 PMID:20550965 PMID:10051439 GO_REF:0000117, RGD:7243113, RGD:2298561 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 enables ISO (MGI:5767077|PMID:9065412), (MGI:5767078|PMID:9078260) RGD PMID:9065412 PMID:9078260 MGI:5767077 MGI:5767078 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 enables ISO (PMID:12464436) RGD PMID:12464436 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mir140 microRNA 140 IMP RGD PMID:28922712 RGD:329347824 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:21177870)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21177870 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Sbk2 SH3 domain binding kinase family, member 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:68,874,081...68,881,918
Ensembl chr 1:68,874,152...68,881,916 		JBrowse link
JUN kinase kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k4 mitogen activated protein kinase kinase 4 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:7768885 PMID:17064355 GO_REF:0000033, RGD:2293351, RGD:2298577 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 enables IDA
ISO
IEA
IBA		 (MGI:1101248|PMID:9405446), (MGI:2182169|PMID:11959862)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:9405446 PMID:11959862 PMID:10051439 PMID:11849756 PMID:17064355 GO_REF:0000033 GO_REF:0000107 MGI:1101248 MGI:2182169, RGD:2298561, RGD:2298565, RGD:2298577 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a protein 2516
        protein kinase activity 628
          protein serine/threonine/tyrosine kinase activity 35
            MAP kinase kinase activity 13
              JUN kinase kinase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      transferase activity 2451
        transferase activity, transferring phosphorus-containing groups 983
          kinase activity 814
            protein kinase activity 628
              protein serine/threonine/tyrosine kinase activity 35
                MAP kinase kinase activity 13
                  JUN kinase kinase activity 2
paths to the root