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Term:cyclin-dependent protein serine/threonine kinase activity
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Accession:GO:0004693 term browser browse the term
Definition:Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
Synonyms:exact_synonym: ATP:cyclin phosphotransferase activity;   CDK activity;   CDK, catalytic subunit activity;   Cdk-activating protein kinase activity;   cyclin-dependent protein kinase, intrinsic catalyst activity
 narrow_synonym: D-type cyclin kinase activity;   cdc2 kinase activity;   cyclin D-cdk6 kinase activity;   cyclin D-dependent kinase activity;   cyclin E kinase activity;   cyclin-A associated kinase activity;   cyclin-dependent kinase 6 activity;   cyclin-dependent kinase-2 activity;   cyclin-dependent kinase-4 activity;   neuronal cdc2-like kinase activity
 broad_synonym: cyclin-dependent kinase activity;   cyclin-dependent protein kinase activity
 related_synonym: CDK;   cdk-activating kinase activity
 alt_id: GO:0016537
 xref: EC:2.7.11.22;   MetaCyc:2.7.11.22-RXN;   reactome:R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex";   reactome:R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex";   reactome:R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2";   reactome:R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2";   reactome:R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2";   reactome:R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2";   reactome:R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75";   reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21";   reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21";   reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2";   reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)";   reactome:R-HSA-188390 "Cyclin E:Cdk2-mediated phosphorylation of Rb";   reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8";   reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB";   reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants";   reactome:R-HSA-2245218 "CDK1 phosphorylates PHF8";   reactome:R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3";   reactome:R-HSA-2430533 "CDK1 phosphorylates MASTL";   reactome:R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres";   reactome:R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms";   reactome:R-HSA-2514854 "CDK1 phosphorylates condensin I";   reactome:R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9";   reactome:R-HSA-2990882 "CDK1 phosphorylates NUP98";   reactome:R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2";   reactome:R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1";   reactome:R-HSA-4086410 "CDK1 phosphorylates BORA";   reactome:R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1";   reactome:R-HSA-5195402 "CDK1 phosphorylates LPIN";   reactome:R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments";   reactome:R-HSA-5692755 "CDK1 phosphorylates MAPK6";   reactome:R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218";   reactome:R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes";   reactome:R-HSA-6805109 "CDK2 phosphorylates TP53";   reactome:R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2";   reactome:R-HSA-69005 "Cdc6 protein is phosphorylated by CDK";   reactome:R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes";   reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes";   reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes";   reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2";   reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2"


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cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:1624291
RGD:1600115
G Ccnk cyclin K JBrowse link 6 132,090,235 132,113,560 RGD:1624291
RGD:1600115
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:632911
RGD:13792537
RGD:1624291
G Cdk10 cyclin-dependent kinase 10 JBrowse link 19 56,024,903 56,032,610 RGD:13792537
G Cdk11b cyclin-dependent kinase 11B JBrowse link 5 173,051,900 173,078,049 RGD:13792537
G Cdk12 cyclin-dependent kinase 12 JBrowse link 10 86,157,186 86,210,657 RGD:13792537
G Cdk14 cyclin-dependent kinase 14 JBrowse link 4 25,825,567 26,419,443 RGD:1624291
RGD:13792537
G Cdk16 cyclin-dependent kinase 16 JBrowse link X 1,707,285 1,718,821 RGD:1600115
G Cdk17 cyclin-dependent kinase 17 JBrowse link 7 34,001,506 34,088,418 RGD:1600115
G Cdk18 cyclin-dependent kinase 18 JBrowse link 13 48,893,525 48,926,673 RGD:1600115
G Cdk19 cyclin-dependent kinase 19 JBrowse link 20 45,458,499 45,598,799 RGD:13792537
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:70277
RGD:13792537
RGD:1624291
RGD:1600115
G Cdk20 cyclin-dependent kinase 20 JBrowse link 17 1,935,900 1,942,867 RGD:13792537
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:704385
RGD:1624291
RGD:13792537
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:69667
RGD:13792537
RGD:8553496
RGD:1598431
RGD:734740
RGD:1598428
RGD:1598417
RGD:1598416
RGD:1598414
RGD:1598412
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:1624291
RGD:13792537
G Cdk7 cyclin-dependent kinase 7 JBrowse link 2 30,710,642 30,735,522 RGD:1302419
RGD:1624291
RGD:13792537
G Cdk9 cyclin-dependent kinase 9 JBrowse link 3 11,742,269 11,747,117 RGD:1624291
RGD:13792537
G Cdkl1 cyclin dependent kinase like 1 JBrowse link 6 92,076,247 92,123,108 RGD:13792537
G Cdkl2 cyclin dependent kinase like 2 JBrowse link 14 17,530,170 17,565,950 RGD:13792537
G Cdkl3 cyclin-dependent kinase-like 3 JBrowse link 10 37,458,397 37,510,345 RGD:13792537

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  molecular_function 18244
    molecular transducer activity 2566
      cyclin-dependent protein kinase activity 22
        cyclin-dependent protein serine/threonine kinase activity 21
Path 2
Term Annotations click to browse term
  molecular_function 18244
    catalytic activity 5760
      transferase activity 2274
        transferase activity, transferring phosphorus-containing groups 956
          kinase activity 807
            protein kinase activity 609
              protein serine/threonine kinase activity 423
                cyclin-dependent protein serine/threonine kinase activity 21
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.