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ONTOLOGY REPORT - ANNOTATIONS

Term:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
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Accession:GO:0004671 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
Synonyms:exact_synonym: protein-S-isoprenylcysteine O-methyltransferase activity
 related_synonym: S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity;   S-farnesylcysteine methyltransferase activity;   farnesyl cysteine C-terminal methyltransferase activity;   farnesyl-protein carboxymethyltransferase activity;   farnesylated protein C-terminal O-methyltransferase activity;   isoprenylated protein methyltransferase activity;   isoprenylcysteine carboxylmethyltransferase activity;   prenylated protein carboxyl methyltransferase activity;   prenylated protein methyltransferase activity;   prenylcysteine carboxyl methyltransferase activity;   prenylcysteine carboxylmethyltransferase activity;   prenylcysteine carboxymethyltransferase activity;   prenylcysteine methyltransferase activity;   protein C-terminal farnesylcysteine O-methyltransferase activity;   protein S-farnesylcysteine C-terminal methyltransferase activity
 alt_id: GO:0018225
 xref: EC:2.1.1.100;   KEGG_REACTION:R04496;   MetaCyc:2.1.1.100-RXN;   RHEA:21672;   Reactome:R-HSA-9647977 "ICMT methylates S-Farn RAS proteins";   reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins"


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protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icmt isoprenylcysteine carboxyl methyltransferase enables IMP
IBA
ISO		 GO_REF:0000033
(PMID:29051265), (PMID:9614111)
MGI:2680650 (PMID:10747846), (PMID:11121396)		 GO_Central
RGD		 PMID:9614111 PMID:10747846 PMID:11121396 PMID:29051265 PMID:9192075 GO_REF:0000033, RGD:2289655 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      catalytic activity, acting on a protein 2496
        protein methyltransferase activity 114
          protein carboxyl O-methyltransferase activity 6
            protein C-terminal carboxyl O-methyltransferase activity 2
              protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      transferase activity 2428
        transferase activity, transferring one-carbon groups 226
          methyltransferase activity 215
            O-methyltransferase activity 24
              carboxyl-O-methyltransferase activity 6
                protein carboxyl O-methyltransferase activity 6
                  protein C-terminal carboxyl O-methyltransferase activity 2
                    protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity 1
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