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ONTOLOGY REPORT - ANNOTATIONS

Term:prostaglandin-endoperoxide synthase activity
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Accession:GO:0004666 term browser browse the term
Definition:Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2.
Synonyms:related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity;   (PG)H synthase activity;   PG synthetase activity;   fatty acid cyclooxygenase activity;   prostaglandin G/H synthase activity;   prostaglandin endoperoxide synthetase activity;   prostaglandin synthase activity;   prostaglandin synthetase activity
 xref: EC:1.14.99.1;   MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN;   RHEA:23728;   Reactome:R-HSA-140355 "Arachidonate is oxidised to PGG2 by PTGS1";   Reactome:R-HSA-2309787 "Arachidonate is oxidised to PGG2 by PTGS2"


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prostaglandin-endoperoxide synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cthrc1 collagen triple helix repeat containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:72,007,372...72,017,654
Ensembl chr 7:70,122,474...70,132,756 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 enables ISO
IEA
IBA		 (PMID:1380156)
GO_REF:0000003
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:1380156 GO_REF:0000003 GO_REF:0000033 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:1380156), (PMID:16373578), (PMID:7592599), (PMID:7947975)
GO_REF:0000033
(PMID:12925531), (PMID:1419907)		 UniProt
RGD
GO_Central		 PMID:1380156 PMID:1419907 PMID:7592599 PMID:7947975 PMID:12925531 More... GO_REF:0000024 GO_REF:0000033 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      oxidoreductase activity 869
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 244
          prostaglandin-endoperoxide synthase activity 3
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