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ONTOLOGY REPORT - ANNOTATIONS

Term:polypeptide N-acetylgalactosaminyltransferase activity
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Accession:GO:0004653 term browser browse the term
Definition:Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.
Synonyms:related_synonym: UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity;   UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity;   UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity;   UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity;   UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity;   glycoprotein acetylgalactosaminyltransferase activity;   polypeptide-N-acetylgalactosamine transferase activity;   protein-UDP acetylgalactosaminyltransferase activity;   uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
 xref: EC:2.4.1.41;   MetaCyc:2.4.1.41-RXN;   Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins";   Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins";   Reactome:R-HSA-913675 "GALNTs transfer GalNAc to Mucins to form Tn antigens";   Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a";   Reactome:R-HSA-9694438 "GalNAc is transferred onto 3a";   reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23"


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polypeptide N-acetylgalactosaminyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galnt1 polypeptide N-acetylgalactosaminyltransferase 1 enables IMP
ISO
IBA
IEA
ISS
IDA		 (PMID:11278534), (PMID:12407114)
GO_REF:0000033
GO_REF:0000117
(PMID:8748160)
GO_REF:0000024
(PMID:22186971), (PMID:8690719), (PMID:9295285)
PMID:12199709		 RGD
GO_Central
UniProt		 PMID:8690719 PMID:8748160 PMID:9295285 PMID:11278534 PMID:12407114 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117, RGD:727444, RGD:151356644 NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245 		JBrowse link
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 enables ISO
IBA
IEA		 (PMID:12417297), (PMID:18562306), (PMID:19460755)
(PMID:11278534)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:11278534 PMID:12417297 PMID:18562306 PMID:19460755 GO_REF:0000033 GO_REF:0000107 NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013 		JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 enables IEA
IBA
ISS
ISO		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
(PMID:24226769)		 UniProt
GO_Central
Ensembl
RGD		 PMID:24226769 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140 		JBrowse link
G Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:61,384,575...61,413,346
Ensembl chr 5:61,384,571...61,413,354 		JBrowse link
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 enables ISO
IBA
IEA		 (PMID:22186971)
(PMID:12407114)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:12407114 PMID:22186971 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:38,903,695...39,560,683
Ensembl chr 3:38,974,490...39,558,803 		JBrowse link
G Galnt14 polypeptide N-acetylgalactosaminyltransferase 14 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:21,756,039...21,977,533
Ensembl chr 6:21,755,195...21,972,192 		JBrowse link
G Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:7,227,232...7,267,002
Ensembl chr16:7,227,271...7,267,014 		JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 enables ISO
IBA		 (PMID:22186971)
GO_REF:0000033		 RGD
GO_Central		 PMID:22186971 GO_REF:0000033 NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705 		JBrowse link
G Galnt17 polypeptide N-acetylgalactosaminyltransferase 17 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:25,323,230...25,781,897
Ensembl chr12:25,322,701...25,781,290 		JBrowse link
G Galnt18 polypeptide N-acetylgalactosaminyltransferase 18 enables ISO
IBA		 (PMID:22186971)
GO_REF:0000033		 RGD
GO_Central		 PMID:22186971 GO_REF:0000033 NCBI chr 1:165,593,180...165,904,268
Ensembl chr 1:165,593,187...165,904,268 		JBrowse link
G Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 enables ISO
IBA		 (PMID:12438318), (PMID:16434399), (PMID:18562306), (PMID:19460755), (PMID:9295285)
GO_REF:0000033		 RGD
GO_Central		 PMID:9295285 PMID:12438318 PMID:16434399 PMID:18562306 PMID:19460755 GO_REF:0000033 NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813 		JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 enables ISO
IBA		 UniProtKB:Q9GZV9 (PMID:17129170), (PMID:31932717), (PMID:8663203), (PMID:9295285)
(PMID:8912633)
GO_REF:0000033		 RGD
GO_Central		 PMID:8663203 PMID:8912633 PMID:9295285 PMID:17129170 PMID:31932717 GO_REF:0000033 NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268 		JBrowse link
G Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 enables ISO (PMID:29208955), (PMID:9804815) RGD PMID:9804815 PMID:29208955 NCBI chr 7:33,925,229...33,927,770 JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 enables ISO
IBA		 (PMID:10545594)
GO_REF:0000033		 RGD
GO_Central		 PMID:10545594 GO_REF:0000033 NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881 		JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 enables ISO
IBA		 (PMID:31932717)
(PMID:10464263)
GO_REF:0000033		 RGD
GO_Central		 PMID:10464263 PMID:31932717 GO_REF:0000033 NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661 		JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:11278534)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:11278534 GO_REF:0000033 GO_REF:0000107 NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690 		JBrowse link
G Galnt9 polypeptide N-acetylgalactosaminyltransferase 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:46,050,395...46,128,626
Ensembl chr12:46,050,413...46,128,578 		JBrowse link
G Galntl6 polypeptide N-acetylgalactosaminyltransferase-like 6 enables ISO (PMID:22186971) RGD PMID:22186971 NCBI chr16:31,192,880...32,443,979
Ensembl chr16:31,186,462...32,441,960 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      catalytic activity, acting on a protein 2509
        polypeptide N-acetylgalactosaminyltransferase activity 18
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      transferase activity 2397
        glycosyltransferase activity 284
          UDP-glycosyltransferase activity 156
            acetylgalactosaminyltransferase activity 36
              polypeptide N-acetylgalactosaminyltransferase activity 18
paths to the root