ONTOLOGY REPORT - ANNOTATIONS
Term: phospholipase A2 activity
Accession: GO:0004623
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Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
Synonyms: narrow_synonym: cytosolic phospholipase A2 activity; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine); secreted phospholipase A2 activity
related_synonym: lecithinase A activity; phosphatidase activity; phosphatidolipase activity; phosphatidylcholine 2-acylhydrolase activity
alt_id: GO:0102567; GO:0102568
xref: EC:3.1.1.4; MetaCyc:PHOSPHOLIPASE-A2-RXN; MetaCyc:RXN-15067; RHEA:15801; reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)"; reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]"; reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A"; reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)"; reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)"; reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]"; reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A"; reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)"; reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]"; reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]"; reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]"; reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]"; reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]"; reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]"; reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]"; reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]"; reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A"; reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]"; reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]"; reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]"; reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]"; reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1"; reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]"; reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]"; reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"
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ABHD3
abhydrolase domain containing 3, phospholipase
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 7:66,331,687...66,383,443
Ensembl chr 7:66,332,410...66,382,942
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LCAT
lecithin-cholesterol acyltransferase
ISO
RGD
PMID:9219904
RGD:729077
NCBI chr 5:81,556,047...81,559,313
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OC90
otoconin 90
enables
IEA
InterPro
GO_REF:0000002
NCBI chr13:28,680,910...28,700,816
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PLA2G10
phospholipase A2 group X
enables
ISO IEA
RGD InterPro
PMID:15781456
GO_REF:0000002 RGD:1582547
NCBI chr 6:28,573,239...28,591,714
Ensembl chr 6:28,574,387...28,591,703
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PLA2G12A
phospholipase A2 group XIIA
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr32:29,913,223...29,929,802
Ensembl chr32:29,916,191...29,929,725
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PLA2G12B
phospholipase A2 group XIIB
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 4:23,539,909...23,561,211
Ensembl chr 4:23,541,258...23,561,041
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PLA2G15
phospholipase A2 group XV
enables
IEA
UniProt RHEA
GO_REF:0000003 GO_REF:0000116
NCBI chr 5:81,269,914...81,280,700
Ensembl chr 5:81,269,920...81,280,700
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PLA2G1B
phospholipase A2 group IB
enables
ISO IEA
RGD RHEA UniProt Ensembl InterPro
PMID:14998370
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 RGD:1302902
NCBI chr26:16,248,417...16,257,163
Ensembl chr26:16,248,409...16,257,178
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PLA2G2C
phospholipase A2 group IIC
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 2:78,609,852...78,700,940
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PLA2G2D
phospholipase A2 group IID
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 2:78,739,826...78,745,839
Ensembl chr 2:78,739,769...78,745,920
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PLA2G2E
phospholipase A2 group IIE
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 2:78,834,820...78,838,058
Ensembl chr 2:78,831,309...78,841,821
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PLA2G2F
phospholipase A2 group IIF
enables
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chr 2:78,714,251...78,724,257
Ensembl chr 2:78,716,228...78,723,984
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PLA2G3
phospholipase A2 group III
enables
IEA
InterPro
GO_REF:0000002
NCBI chr26:24,127,074...24,132,508
Ensembl chr26:24,128,005...24,132,508
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PLA2G4A
phospholipase A2 group IVA
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
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PLA2G4D
phospholipase A2 group IVD
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr30:9,091,147...9,115,090
Ensembl chr30:9,092,001...9,115,363
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PLA2G4E
phospholipase A2 group IVE
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr30:9,018,238...9,077,258
Ensembl chr30:9,020,079...9,075,999
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PLA2G4F
phospholipase A2 group IVF
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr30:9,150,325...9,165,610
Ensembl chr30:9,150,971...9,164,608
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PLA2G5
phospholipase A2 group V
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 2:78,762,851...78,781,642
Ensembl chr 2:78,762,852...78,781,983
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PLAAT1
phospholipase A and acyltransferase 1
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr34:24,751,404...24,770,690
Ensembl chr34:24,760,155...24,770,690
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PLAAT3
phospholipase A and acyltransferase 3
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr18:53,367,441...53,412,165
Ensembl chr18:53,368,030...53,398,290
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PLAAT4
phospholipase A and acyltransferase 4
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr18:53,418,184...53,424,027
Ensembl chr18:53,418,368...53,423,886
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PLAAT5
phospholipase A and acyltransferase 5
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr18:53,451,302...53,465,375
Ensembl chr18:53,450,387...53,463,314
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PLB1
phospholipase B1
enables
ISO IBA
RGD GO_Central
PMID:1716922
GO_REF:0000033 RGD:6903950
NCBI chr17:22,420,679...22,558,318
Ensembl chr17:22,440,651...22,557,737
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PNPLA2
patatin like phospholipase domain containing 2
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr18:45,182,569...45,187,937
Ensembl chr18:45,182,566...45,187,268
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PNPLA3
patatin like phospholipase domain containing 3
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr10:21,708,439...21,722,282
Ensembl chr10:21,712,378...21,722,135
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PNPLA4
patatin like phospholipase domain containing 4
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr X:4,775,702...4,925,027
Ensembl chr X:4,874,240...4,924,976
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PRDX6
peroxiredoxin 6
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
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PROCA1
protein interacting with cyclin A1
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 9:42,897,015...42,904,460
Ensembl chr 9:42,897,392...42,904,432
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PLA2G10
phospholipase A2 group X
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 6:28,573,239...28,591,714
Ensembl chr 6:28,574,387...28,591,703
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PLA2G1B
phospholipase A2 group IB
enables
ISO IBA ISS IEA
RGD GO_Central UniProt Ensembl
PMID:9487151
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:2303763
NCBI chr26:16,248,417...16,257,163
Ensembl chr26:16,248,409...16,257,178
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PLA2G2C
phospholipase A2 group IIC
enables
ISO IBA
RGD GO_Central
PMID:8083202
GO_REF:0000033 RGD:69933
NCBI chr 2:78,609,852...78,700,940
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PLA2G2D
phospholipase A2 group IID
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:78,739,826...78,745,839
Ensembl chr 2:78,739,769...78,745,920
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PLA2G2E
phospholipase A2 group IIE
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:78,834,820...78,838,058
Ensembl chr 2:78,831,309...78,841,821
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PLA2G2F
phospholipase A2 group IIF
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:78,714,251...78,724,257
Ensembl chr 2:78,716,228...78,723,984
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PLA2G3
phospholipase A2 group III
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr26:24,127,074...24,132,508
Ensembl chr26:24,128,005...24,132,508
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PLA2G4A
phospholipase A2 group IVA
enables
ISO IBA IEA
RGD GO_Central Ensembl
PMID:8148815
GO_REF:0000033 GO_REF:0000107 RGD:1642483
NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
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PLA2G4B
phospholipase A2 group IVB
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr30:8,865,941...8,878,687
Ensembl chr30:8,859,257...8,876,395
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PLA2G4D
phospholipase A2 group IVD
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr30:9,091,147...9,115,090
Ensembl chr30:9,092,001...9,115,363
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PLA2G4E
phospholipase A2 group IVE
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr30:9,018,238...9,077,258
Ensembl chr30:9,020,079...9,075,999
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PLA2G4F
phospholipase A2 group IVF
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr30:9,150,325...9,165,610
Ensembl chr30:9,150,971...9,164,608
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PLA2G5
phospholipase A2 group V
enables
ISO IBA
RGD GO_Central
PMID:7947992
GO_REF:0000033 RGD:61698
NCBI chr 2:78,762,851...78,781,642
Ensembl chr 2:78,762,852...78,781,983
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PLA2G15
phospholipase A2 group XV
enables
ISO ISS IEA
RGD UniProt Ensembl
PMID:15294901
GO_REF:0000024 GO_REF:0000107 RGD:1304489
NCBI chr 5:81,269,914...81,280,700
Ensembl chr 5:81,269,920...81,280,700
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PLA2G4A
phospholipase A2 group IVA
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
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PLA2G5
phospholipase A2 group V
enables
ISO
(PMID:23533611)
UniProt
PMID:23533611
NCBI chr 2:78,762,851...78,781,642
Ensembl chr 2:78,762,852...78,781,983
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PLA2G6
phospholipase A2 group VI
enables
ISO IEA IBA
RGD Ensembl InterPro GO_Central
PMID:9111008
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:729507
NCBI chr10:26,499,033...26,559,533
Ensembl chr10:26,509,695...26,634,087
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PLA2G7
phospholipase A2 group VII
enables
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr12:14,866,229...14,908,230
Ensembl chr12:14,866,229...14,908,114
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PLB1
phospholipase B1
enables
ISO
PMID:9442065 PMID:9442064
UniProt
PMID:9442064 PMID:9442065
RGD:30309923 RGD:633237
NCBI chr17:22,420,679...22,558,318
Ensembl chr17:22,440,651...22,557,737
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PNPLA8
patatin like phospholipase domain containing 8
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr18:12,134,921...12,181,496
Ensembl chr18:12,141,830...12,179,974
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PRDX6
peroxiredoxin 6
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
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