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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
Synonyms:narrow_synonym: cytosolic phospholipase A2 activity;   phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine);   phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine);   secreted phospholipase A2 activity
 related_synonym: lecithinase A activity;   phosphatidase activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 alt_id: GO:0102567;   GO:0102568
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   MetaCyc:RXN-15067;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"



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phospholipase A2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD3 abhydrolase domain containing 3, phospholipase enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 7:66,331,687...66,383,443
Ensembl chr 7:66,332,410...66,382,942
JBrowse link
G LCAT lecithin-cholesterol acyltransferase ISO RGD PMID:9219904 RGD:729077 NCBI chr 5:81,556,047...81,559,313 JBrowse link
G OC90 otoconin 90 enables IEA InterPro GO_REF:0000002 NCBI chr13:28,680,910...28,700,816 JBrowse link
G PLA2G10 phospholipase A2 group X enables ISO
IEA
RGD
InterPro
PMID:15781456 GO_REF:0000002 RGD:1582547 NCBI chr 6:28,573,239...28,591,714
Ensembl chr 6:28,574,387...28,591,703
JBrowse link
G PLA2G12A phospholipase A2 group XIIA enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr32:29,913,223...29,929,802
Ensembl chr32:29,916,191...29,929,725
JBrowse link
G PLA2G12B phospholipase A2 group XIIB enables IEA InterPro GO_REF:0000002 NCBI chr 4:23,539,909...23,561,211
Ensembl chr 4:23,541,258...23,561,041
JBrowse link
G PLA2G15 phospholipase A2 group XV enables IEA UniProt
RHEA
GO_REF:0000003 GO_REF:0000116 NCBI chr 5:81,269,914...81,280,700
Ensembl chr 5:81,269,920...81,280,700
JBrowse link
G PLA2G1B phospholipase A2 group IB enables ISO
IEA
RGD
RHEA
UniProt
Ensembl
InterPro
PMID:14998370 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 RGD:1302902 NCBI chr26:16,248,417...16,257,163
Ensembl chr26:16,248,409...16,257,178
JBrowse link
G PLA2G2C phospholipase A2 group IIC enables IEA InterPro GO_REF:0000002 NCBI chr 2:78,609,852...78,700,940 JBrowse link
G PLA2G2D phospholipase A2 group IID enables IEA InterPro GO_REF:0000002 NCBI chr 2:78,739,826...78,745,839
Ensembl chr 2:78,739,769...78,745,920
JBrowse link
G PLA2G2E phospholipase A2 group IIE enables IEA InterPro GO_REF:0000002 NCBI chr 2:78,834,820...78,838,058
Ensembl chr 2:78,831,309...78,841,821
JBrowse link
G PLA2G2F phospholipase A2 group IIF enables IEA InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 NCBI chr 2:78,714,251...78,724,257
Ensembl chr 2:78,716,228...78,723,984
JBrowse link
G PLA2G3 phospholipase A2 group III enables IEA InterPro GO_REF:0000002 NCBI chr26:24,127,074...24,132,508
Ensembl chr26:24,128,005...24,132,508
JBrowse link
G PLA2G4A phospholipase A2 group IVA enables IEA Ensembl GO_REF:0000107 NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
JBrowse link
G PLA2G4D phospholipase A2 group IVD enables IEA Ensembl GO_REF:0000107 NCBI chr30:9,091,147...9,115,090
Ensembl chr30:9,092,001...9,115,363
JBrowse link
G PLA2G4E phospholipase A2 group IVE enables IEA Ensembl GO_REF:0000107 NCBI chr30:9,018,238...9,077,258
Ensembl chr30:9,020,079...9,075,999
JBrowse link
G PLA2G4F phospholipase A2 group IVF enables IEA Ensembl GO_REF:0000107 NCBI chr30:9,150,325...9,165,610
Ensembl chr30:9,150,971...9,164,608
JBrowse link
G PLA2G5 phospholipase A2 group V enables IEA InterPro GO_REF:0000002 NCBI chr 2:78,762,851...78,781,642
Ensembl chr 2:78,762,852...78,781,983
JBrowse link
G PLAAT1 phospholipase A and acyltransferase 1 enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr34:24,751,404...24,770,690
Ensembl chr34:24,760,155...24,770,690
JBrowse link
G PLAAT3 phospholipase A and acyltransferase 3 enables IBA GO_Central GO_REF:0000033 NCBI chr18:53,367,441...53,412,165
Ensembl chr18:53,368,030...53,398,290
JBrowse link
G PLAAT4 phospholipase A and acyltransferase 4 enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr18:53,418,184...53,424,027
Ensembl chr18:53,418,368...53,423,886
JBrowse link
G PLAAT5 phospholipase A and acyltransferase 5 enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr18:53,451,302...53,465,375
Ensembl chr18:53,450,387...53,463,314
JBrowse link
G PLB1 phospholipase B1 enables ISO
IBA
RGD
GO_Central
PMID:1716922 GO_REF:0000033 RGD:6903950 NCBI chr17:22,420,679...22,558,318
Ensembl chr17:22,440,651...22,557,737
JBrowse link
G PNPLA2 patatin like phospholipase domain containing 2 enables IEA Ensembl GO_REF:0000107 NCBI chr18:45,182,569...45,187,937
Ensembl chr18:45,182,566...45,187,268
JBrowse link
G PNPLA3 patatin like phospholipase domain containing 3 enables IEA Ensembl GO_REF:0000107 NCBI chr10:21,708,439...21,722,282
Ensembl chr10:21,712,378...21,722,135
JBrowse link
G PNPLA4 patatin like phospholipase domain containing 4 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:4,775,702...4,925,027
Ensembl chr  X:4,874,240...4,924,976
JBrowse link
G PRDX6 peroxiredoxin 6 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
JBrowse link
G PROCA1 protein interacting with cyclin A1 enables IEA InterPro GO_REF:0000002 NCBI chr 9:42,897,015...42,904,460
Ensembl chr 9:42,897,392...42,904,432
JBrowse link
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G10 phospholipase A2 group X enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 6:28,573,239...28,591,714
Ensembl chr 6:28,574,387...28,591,703
JBrowse link
G PLA2G1B phospholipase A2 group IB enables ISO
IBA
ISS
IEA
RGD
GO_Central
UniProt
Ensembl
PMID:9487151 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:2303763 NCBI chr26:16,248,417...16,257,163
Ensembl chr26:16,248,409...16,257,178
JBrowse link
G PLA2G2C phospholipase A2 group IIC enables ISO
IBA
RGD
GO_Central
PMID:8083202 GO_REF:0000033 RGD:69933 NCBI chr 2:78,609,852...78,700,940 JBrowse link
G PLA2G2D phospholipase A2 group IID enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 2:78,739,826...78,745,839
Ensembl chr 2:78,739,769...78,745,920
JBrowse link
G PLA2G2E phospholipase A2 group IIE enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 2:78,834,820...78,838,058
Ensembl chr 2:78,831,309...78,841,821
JBrowse link
G PLA2G2F phospholipase A2 group IIF enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 2:78,714,251...78,724,257
Ensembl chr 2:78,716,228...78,723,984
JBrowse link
G PLA2G3 phospholipase A2 group III enables IEA Ensembl GO_REF:0000107 NCBI chr26:24,127,074...24,132,508
Ensembl chr26:24,128,005...24,132,508
JBrowse link
G PLA2G4A phospholipase A2 group IVA enables ISO
IBA
IEA
RGD
GO_Central
Ensembl
PMID:8148815 GO_REF:0000033 GO_REF:0000107 RGD:1642483 NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
JBrowse link
G PLA2G4B phospholipase A2 group IVB enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr30:8,865,941...8,878,687
Ensembl chr30:8,859,257...8,876,395
JBrowse link
G PLA2G4D phospholipase A2 group IVD enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr30:9,091,147...9,115,090
Ensembl chr30:9,092,001...9,115,363
JBrowse link
G PLA2G4E phospholipase A2 group IVE enables IBA GO_Central GO_REF:0000033 NCBI chr30:9,018,238...9,077,258
Ensembl chr30:9,020,079...9,075,999
JBrowse link
G PLA2G4F phospholipase A2 group IVF enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr30:9,150,325...9,165,610
Ensembl chr30:9,150,971...9,164,608
JBrowse link
G PLA2G5 phospholipase A2 group V enables ISO
IBA
RGD
GO_Central
PMID:7947992 GO_REF:0000033 RGD:61698 NCBI chr 2:78,762,851...78,781,642
Ensembl chr 2:78,762,852...78,781,983
JBrowse link
calcium-independent phospholipase A2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G15 phospholipase A2 group XV enables ISO
ISS
IEA
RGD
UniProt
Ensembl
PMID:15294901 GO_REF:0000024 GO_REF:0000107 RGD:1304489 NCBI chr 5:81,269,914...81,280,700
Ensembl chr 5:81,269,920...81,280,700
JBrowse link
G PLA2G4A phospholipase A2 group IVA enables IEA Ensembl GO_REF:0000107 NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
JBrowse link
G PLA2G5 phospholipase A2 group V enables ISO (PMID:23533611) UniProt PMID:23533611 NCBI chr 2:78,762,851...78,781,642
Ensembl chr 2:78,762,852...78,781,983
JBrowse link
G PLA2G6 phospholipase A2 group VI enables ISO
IEA
IBA
RGD
Ensembl
InterPro
GO_Central
PMID:9111008 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:729507 NCBI chr10:26,499,033...26,559,533
Ensembl chr10:26,509,695...26,634,087
JBrowse link
G PLA2G7 phospholipase A2 group VII enables ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr12:14,866,229...14,908,230
Ensembl chr12:14,866,229...14,908,114
JBrowse link
G PLB1 phospholipase B1 enables ISO PMID:9442065
PMID:9442064
UniProt PMID:9442064 PMID:9442065 RGD:30309923 RGD:633237 NCBI chr17:22,420,679...22,558,318
Ensembl chr17:22,440,651...22,557,737
JBrowse link
G PNPLA8 patatin like phospholipase domain containing 8 enables IBA GO_Central GO_REF:0000033 NCBI chr18:12,134,921...12,181,496
Ensembl chr18:12,141,830...12,179,974
JBrowse link
G PRDX6 peroxiredoxin 6 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 21951
    catalytic activity 5724
      hydrolase activity 2454
        hydrolase activity, acting on ester bonds 763
          lipase activity 117
            phospholipase activity 96
              phospholipase A2 activity 32
                calcium-dependent phospholipase A2 activity 13
                calcium-independent phospholipase A2 activity 8
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