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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
Synonyms:narrow_synonym: cytosolic phospholipase A2 activity;   phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine);   phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine);   secreted phospholipase A2 activity
 related_synonym: lecithinase A activity;   phosphatidase activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 alt_id: GO:0102567;   GO:0102568
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   MetaCyc:RXN-15067;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"



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phospholipase A2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd3 abhydrolase domain containing 3, phospholipase enables ISO
IBA
(PMID:21926997)
GO_REF:0000033
RGD
GO_Central
PMID:21926997 GO_REF:0000033 NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428
JBrowse link
G ENSRNOG00000067664 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 6:100,679,532...100,680,668 JBrowse link
G Lcat lecithin cholesterol acyltransferase IDA RGD PMID:9219904 RGD:729077 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Pla2g10 phospholipase A2, group X enables IDA
IEA
GO_REF:0000002
GO_REF:0000117
InterPro
UniProt
RGD
PMID:15781456 GO_REF:0000002 GO_REF:0000117, RGD:1582547 NCBI chr10:2,104,927...2,117,998
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Pla2g12a phospholipase A2, group XIIA enables IBA
ISO
GO_REF:0000033
(PMID:11278438)
GO_Central
RGD
PMID:11278438 GO_REF:0000033 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pla2g12b phospholipase A2, group XIIB enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:27,910,620...27,931,734
Ensembl chr20:27,370,266...27,388,743
JBrowse link
G Pla2g1b phospholipase A2 group IB enables IDA
ISO
(PMID:15528384), (PMID:1918029)
(PMID:10531313)
(PMID:1918029)
RGD PMID:1918029 PMID:10531313 PMID:15528384 PMID:14998370 PMID:1918029 RGD:1302902, RGD:8553780 NCBI chr12:46,802,932...46,814,511
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pla2g2a phospholipase A2 group IIA enables TAS
ISO
(PMID:17069818) RGD PMID:17069818 PMID:12188923 RGD:628361 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pla2g2c phospholipase A2, group IIC enables IEA GO_REF:0000117
GO_REF:0000003
UniProt GO_REF:0000003 GO_REF:0000117 NCBI chr 5:156,241,142...156,262,368
Ensembl chr 5:150,959,182...150,981,377
JBrowse link
G Pla2g2f phospholipase A2, group IIF enables ISO (PMID:16931517) RGD PMID:16931517 NCBI chr 5:156,270,077...156,276,464
Ensembl chr 5:150,986,788...150,993,175
JBrowse link
G Pla2g4a phospholipase A2 group 4A enables TAS
ISO
IEA
(PMID:10946309)
GO_REF:0000117
(PMID:8702602)
RGD
UniProt
PMID:8702602 PMID:10946309 PMID:12051686 GO_REF:0000117, RGD:633563 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g4d phospholipase A2 group IVD enables ISO (PMID:15866882) RGD PMID:15866882 NCBI chr 3:127,674,743...127,695,991
Ensembl chr 3:107,220,978...107,242,224
JBrowse link
G Pla2g4e phospholipase A2, group IVE enables ISO (PMID:15866882) RGD PMID:15866882 NCBI chr 3:127,586,318...127,652,369
Ensembl chr 3:107,132,541...107,198,233
JBrowse link
G Pla2g4f phospholipase A2, group IVF enables ISO (PMID:15866882), (PMID:17293613) RGD PMID:15866882 PMID:17293613 NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:107,250,075...107,264,689
JBrowse link
G Pla2g5 phospholipase A2, group V enables IEA
ISO
GO_REF:0000117
(PMID:11830583)
UniProt
RGD
PMID:11830583 GO_REF:0000117 NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Pla2g6 phospholipase A2 group VI enables TAS Reactome:R-RNO-1482836 Reactome Reactome:R-RNO-1482836 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 enables ISO
IBA
(PMID:21880860), (PMID:22825852), (PMID:27623847)
GO_REF:0000033
RGD
GO_Central
PMID:21880860 PMID:22825852 PMID:27623847 GO_REF:0000033 NCBI chr11:85,022,297...85,041,999
Ensembl chr11:71,517,493...71,527,020
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 enables IDA
ISO
IEA
IBA
PMID:19047760
(PMID:19047760), (PMID:20100577), (PMID:22825852)
GO_REF:0000107
GO_REF:0000033
(PMID:18614531), (PMID:19047760), (PMID:22134920)
RGD
Ensembl
GO_Central
PMID:18614531 PMID:19047760 PMID:20100577 PMID:22134920 PMID:22825852 More... GO_REF:0000033 GO_REF:0000107, RGD:12790655 NCBI chr 1:214,211,755...214,245,551
Ensembl chr 1:204,782,729...204,817,667
JBrowse link
G Plaat5 phospholipase A and acyltransferase 5 enables ISO
IBA
IEA
(PMID:22825852)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:22825852 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:204,847,600...204,878,456
Ensembl chr 1:204,847,600...204,878,184
JBrowse link
G Plb1 phospholipase B1 enables IDA
IBA
IEA
GO_REF:0000033
GO_REF:0000003
GO_Central
UniProt
RGD
PMID:1716922 GO_REF:0000003 GO_REF:0000033, RGD:6903950 NCBI chr 6:29,807,127...29,945,607
Ensembl chr 6:24,089,214...24,210,117
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 enables ISS
ISO
GO_REF:0000024
(PMID:15364929), (PMID:17032652)
UniProt
RGD
PMID:15364929 PMID:17032652 GO_REF:0000024 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 enables ISO (PMID:15364929) RGD PMID:15364929 NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:115,293,538...115,314,077
JBrowse link
G Pnpla4 patatin like phospholipase domain containing 4 enables ISO (PMID:15364929) RGD PMID:15364929 NCBI chr  X:46,200,351...46,205,517
Ensembl chr  X:42,305,373...42,318,552
JBrowse link
G Prdx6 peroxiredoxin 6 enables ISO (PMID:26830860) RGD PMID:26830860 NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Proca1 protein interacting with cyclin A1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:63,588,061...63,601,011
Ensembl chr10:63,090,018...63,102,940
JBrowse link
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oc90 otoconin 90 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:97,635,890...97,669,303
Ensembl chr 7:97,635,890...97,669,416
JBrowse link
G Pla2g10 phospholipase A2, group X enables ISO
ISS
IEA
IBA
(PMID:12021277), (PMID:12359733), (PMID:16146426), (PMID:16962371)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:12359733)
RGD
UniProt
Ensembl
GO_Central
PMID:12021277 PMID:12359733 PMID:16146426 PMID:16962371 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:2,104,927...2,117,998
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Pla2g1b phospholipase A2 group IB enables IDA
ISO
IEA
IBA
(PMID:1420353), (PMID:17603006), (PMID:7060561)
(PMID:17603006)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:1420353 PMID:7060561 PMID:17603006 PMID:9487151 GO_REF:0000033 GO_REF:0000107, RGD:2303763 NCBI chr12:46,802,932...46,814,511
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pla2g2a phospholipase A2 group IIA enables IDA
IBA
ISO
GO_REF:0000033
(PMID:10358193), (PMID:25082876)
GO_Central
RGD
PMID:10358193 PMID:25082876 PMID:9487151 GO_REF:0000033, RGD:2303763 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pla2g2c phospholipase A2, group IIC enables IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:8083202 GO_REF:0000033, RGD:69933 NCBI chr 5:156,241,142...156,262,368
Ensembl chr 5:150,959,182...150,981,377
JBrowse link
G Pla2g2d phospholipase A2, group IID enables ISO
IBA
(PMID:10681567)
(PMID:10531313), (PMID:23690440)
GO_REF:0000033
RGD
GO_Central
PMID:10531313 PMID:10681567 PMID:23690440 GO_REF:0000033 NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:151,018,870...151,022,525
JBrowse link
G Pla2g2e phospholipase A2, group IIE enables ISO (PMID:28883454)
(PMID:10531313)
RGD PMID:10531313 PMID:28883454 NCBI chr 5:151,121,363...151,127,147
Ensembl chr 5:151,121,439...151,126,821
JBrowse link
G Pla2g2f phospholipase A2, group IIF enables ISO
IBA
(PMID:11112443)
GO_REF:0000033
RGD
GO_Central
PMID:11112443 GO_REF:0000033 NCBI chr 5:156,270,077...156,276,464
Ensembl chr 5:150,986,788...150,993,175
JBrowse link
G Pla2g3 phospholipase A2, group III enables ISO (PMID:12522102), (PMID:18801741), (PMID:28947740)
(PMID:23624557)
RGD PMID:12522102 PMID:18801741 PMID:23624557 PMID:28947740 NCBI chr14:82,589,908...82,597,542
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g4a phospholipase A2 group 4A enables IDA
ISO
IBA
IEA
(PMID:9403693)
GO_REF:0000033
GO_REF:0000107
(PMID:14709560), (PMID:16617059), (PMID:17472963), (PMID:18451993), (PMID:7794891), (PMID:9425121)
RGD
GO_Central
Ensembl
PMID:7794891 PMID:9403693 PMID:9425121 PMID:14709560 PMID:16617059 More... GO_REF:0000033 GO_REF:0000107, RGD:1642483 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g4b phospholipase A2 group IVB enables ISO
IBA
(PMID:10358058), (PMID:16617059)
GO_REF:0000033
(PMID:10085124)
RGD
GO_Central
PMID:10085124 PMID:10358058 PMID:16617059 GO_REF:0000033 NCBI chr 3:127,458,022...127,467,637
Ensembl chr 3:107,005,489...107,013,853
JBrowse link
G Pla2g4c phospholipase A2 group IVC enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:74,236,211...74,274,656
JBrowse link
G Pla2g4d phospholipase A2 group IVD enables ISO
IBA
(PMID:14709560)
GO_REF:0000033
RGD
GO_Central
PMID:14709560 GO_REF:0000033 NCBI chr 3:127,674,743...127,695,991
Ensembl chr 3:107,220,978...107,242,224
JBrowse link
G Pla2g4e phospholipase A2, group IVE enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:127,586,318...127,652,369
Ensembl chr 3:107,132,541...107,198,233
JBrowse link
G Pla2g4f phospholipase A2, group IVF enables IBA
ISO
GO_REF:0000033
(PMID:17293613)
GO_Central
RGD
PMID:17293613 GO_REF:0000033 NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:107,250,075...107,264,689
JBrowse link
G Pla2g5 phospholipase A2, group V enables IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:7947992 GO_REF:0000033, RGD:61698 NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
calcium-independent phospholipase A2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g15 phospholipase A2, group XV enables IDA
ISO
IBA
(PMID:29724779)
GO_REF:0000033
(PMID:11790796), (PMID:16837646), (PMID:17626977)
RGD
GO_Central
PMID:11790796 PMID:16837646 PMID:17626977 PMID:29724779 PMID:15294901 GO_REF:0000033, RGD:1304489 NCBI chr19:50,960,568...50,977,948
Ensembl chr19:34,050,694...34,068,063
JBrowse link
G Pla2g4a phospholipase A2 group 4A enables ISO
IEA
(PMID:12672805)
GO_REF:0000107
RGD
Ensembl
PMID:12672805 GO_REF:0000107 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g4c phospholipase A2 group IVC enables ISO (PMID:10085124) RGD PMID:10085124 NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:74,236,211...74,274,656
JBrowse link
G Pla2g5 phospholipase A2, group V enables ISO
IEA
(PMID:23533611)
GO_REF:0000107
RGD
Ensembl
PMID:23533611 GO_REF:0000107 NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Pla2g6 phospholipase A2 group VI enables IDA
ISO
IEA
IBA
PMID:18937505
PMID:24648512
(PMID:15908428), (PMID:20886109), (PMID:23533611)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:17895289), (PMID:18937505)
RGD
InterPro
Ensembl
GO_Central
PMID:15908428 PMID:17895289 PMID:18937505 PMID:20886109 PMID:23533611 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:729507, RGD:25671384, RGD:25671395 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Pla2g7 phospholipase A2 group VII enables ISO (PMID:2040620), (PMID:8624782) RGD PMID:2040620 PMID:8624782 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Plb1 phospholipase B1 enables IDA PMID:9442065
PMID:9442064
UniProt PMID:9442065 PMID:9442064 RGD:633237, RGD:30309923 NCBI chr 6:29,807,127...29,945,607
Ensembl chr 6:24,089,214...24,210,117
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 enables ISS
ISO
IBA
GO_REF:0000024
(PMID:10744668), (PMID:10833412), (PMID:15695510), (PMID:15908428), (PMID:18171998), (PMID:28442572)
GO_REF:0000033
(PMID:28442572)
UniProt
RGD
GO_Central
PMID:10744668 PMID:10833412 PMID:15695510 PMID:15908428 PMID:18171998 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:61,329,810...61,391,734
JBrowse link
G Prdx6 peroxiredoxin 6 enables ISO (PMID:10893423) RGD PMID:10893423 NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 823
          lipase activity 124
            phospholipase activity 101
              phospholipase A2 activity 34
                calcium-dependent phospholipase A2 activity 16
                calcium-independent phospholipase A2 activity 9
paths to the root