ONTOLOGY REPORT - ANNOTATIONS
Term: phospholipase A2 activity
Accession: GO:0004623
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Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
Synonyms: narrow_synonym: cytosolic phospholipase A2 activity; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine); secreted phospholipase A2 activity
related_synonym: lecithinase A activity; phosphatidase activity; phosphatidolipase activity; phosphatidylcholine 2-acylhydrolase activity
alt_id: GO:0102567; GO:0102568
xref: EC:3.1.1.4; MetaCyc:PHOSPHOLIPASE-A2-RXN; MetaCyc:RXN-15067; RHEA:15801; reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)"; reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]"; reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A"; reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)"; reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)"; reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]"; reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A"; reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)"; reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]"; reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]"; reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]"; reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]"; reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]"; reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]"; reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]"; reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]"; reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A"; reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]"; reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]"; reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]"; reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]"; reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1"; reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]"; reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]"; reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"
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Abhd3
abhydrolase domain containing 3, phospholipase
enables
ISO IBA
(PMID:21926997) GO_REF:0000033
RGD GO_Central
PMID:21926997
GO_REF:0000033
NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428
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ENSRNOG00000067664
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
Ensembl chr 6:100,679,532...100,680,668
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Lcat
lecithin cholesterol acyltransferase
IDA
RGD
PMID:9219904
RGD:729077
NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
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Pla2g10
phospholipase A2, group X
enables
IDA IEA
GO_REF:0000002 GO_REF:0000117
InterPro UniProt RGD
PMID:15781456
GO_REF:0000002 GO_REF:0000117, RGD:1582547
NCBI chr10:2,104,927...2,117,998
Ensembl chr10:1,597,761...1,609,000
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Pla2g12a
phospholipase A2, group XIIA
enables
IBA ISO
GO_REF:0000033 (PMID:11278438)
GO_Central RGD
PMID:11278438
GO_REF:0000033
NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:218,436,513...218,452,740
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Pla2g12b
phospholipase A2, group XIIB
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr20:27,910,620...27,931,734
Ensembl chr20:27,370,266...27,388,743
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Pla2g1b
phospholipase A2 group IB
enables
IDA ISO
(PMID:15528384), (PMID:1918029) (PMID:10531313) (PMID:1918029)
RGD
PMID:1918029 PMID:10531313 PMID:15528384 PMID:14998370 PMID:1918029
RGD:1302902 , RGD:8553780
NCBI chr12:46,802,932...46,814,511
Ensembl chr12:41,142,200...41,153,226
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Pla2g2a
phospholipase A2 group IIA
enables
TAS ISO
(PMID:17069818)
RGD
PMID:17069818 PMID:12188923
RGD:628361
NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014
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Pla2g2c
phospholipase A2, group IIC
enables
IEA
GO_REF:0000117 GO_REF:0000003
UniProt
GO_REF:0000003 GO_REF:0000117
NCBI chr 5:156,241,142...156,262,368
Ensembl chr 5:150,959,182...150,981,377
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Pla2g2f
phospholipase A2, group IIF
enables
ISO
(PMID:16931517)
RGD
PMID:16931517
NCBI chr 5:156,270,077...156,276,464
Ensembl chr 5:150,986,788...150,993,175
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Pla2g4a
phospholipase A2 group 4A
enables
TAS ISO IEA
(PMID:10946309) GO_REF:0000117 (PMID:8702602)
RGD UniProt
PMID:8702602 PMID:10946309 PMID:12051686
GO_REF:0000117, RGD:633563
NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
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Pla2g4d
phospholipase A2 group IVD
enables
ISO
(PMID:15866882)
RGD
PMID:15866882
NCBI chr 3:127,674,743...127,695,991
Ensembl chr 3:107,220,978...107,242,224
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Pla2g4e
phospholipase A2, group IVE
enables
ISO
(PMID:15866882)
RGD
PMID:15866882
NCBI chr 3:127,586,318...127,652,369
Ensembl chr 3:107,132,541...107,198,233
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Pla2g4f
phospholipase A2, group IVF
enables
ISO
(PMID:15866882), (PMID:17293613)
RGD
PMID:15866882 PMID:17293613
NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:107,250,075...107,264,689
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Pla2g5
phospholipase A2, group V
enables
IEA ISO
GO_REF:0000117 (PMID:11830583)
UniProt RGD
PMID:11830583
GO_REF:0000117
NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658
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Pla2g6
phospholipase A2 group VI
enables
TAS
Reactome:R-RNO-1482836
Reactome
Reactome:R-RNO-1482836
NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114
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Plaat1
phospholipase A and acyltransferase 1
enables
ISO IBA
(PMID:21880860), (PMID:22825852), (PMID:27623847) GO_REF:0000033
RGD GO_Central
PMID:21880860 PMID:22825852 PMID:27623847
GO_REF:0000033
NCBI chr11:85,022,297...85,041,999
Ensembl chr11:71,517,493...71,527,020
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Plaat3
phospholipase A and acyltransferase 3
enables
IDA ISO IEA IBA
PMID:19047760 (PMID:19047760), (PMID:20100577), (PMID:22825852) GO_REF:0000107 GO_REF:0000033 (PMID:18614531), (PMID:19047760), (PMID:22134920)
RGD Ensembl GO_Central
PMID:18614531 PMID:19047760 PMID:20100577 PMID:22134920 PMID:22825852 PMID:19047760 More...
GO_REF:0000033 GO_REF:0000107, RGD:12790655
NCBI chr 1:214,211,755...214,245,551
Ensembl chr 1:204,782,729...204,817,667
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Plaat5
phospholipase A and acyltransferase 5
enables
ISO IBA IEA
(PMID:22825852) GO_REF:0000033 GO_REF:0000107
RGD GO_Central Ensembl
PMID:22825852
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:204,847,600...204,878,456
Ensembl chr 1:204,847,600...204,878,184
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Plb1
phospholipase B1
enables
IDA IBA IEA
GO_REF:0000033 GO_REF:0000003
GO_Central UniProt RGD
PMID:1716922
GO_REF:0000003 GO_REF:0000033, RGD:6903950
NCBI chr 6:29,807,127...29,945,607
Ensembl chr 6:24,089,214...24,210,117
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Pnpla2
patatin-like phospholipase domain containing 2
enables
ISS ISO
GO_REF:0000024 (PMID:15364929), (PMID:17032652)
UniProt RGD
PMID:15364929 PMID:17032652
GO_REF:0000024
NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
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Pnpla3
patatin-like phospholipase domain containing 3
enables
ISO
(PMID:15364929)
RGD
PMID:15364929
NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:115,293,538...115,314,077
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Pnpla4
patatin like phospholipase domain containing 4
enables
ISO
(PMID:15364929)
RGD
PMID:15364929
NCBI chr X:46,200,351...46,205,517
Ensembl chr X:42,305,373...42,318,552
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Prdx6
peroxiredoxin 6
enables
ISO
(PMID:26830860)
RGD
PMID:26830860
NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
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Proca1
protein interacting with cyclin A1
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr10:63,588,061...63,601,011
Ensembl chr10:63,090,018...63,102,940
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Oc90
otoconin 90
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:97,635,890...97,669,303
Ensembl chr 7:97,635,890...97,669,416
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Pla2g10
phospholipase A2, group X
enables
ISO ISS IEA IBA
(PMID:12021277), (PMID:12359733), (PMID:16146426), (PMID:16962371) GO_REF:0000024 GO_REF:0000107 GO_REF:0000033 (PMID:12359733)
RGD UniProt Ensembl GO_Central
PMID:12021277 PMID:12359733 PMID:16146426 PMID:16962371
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr10:2,104,927...2,117,998
Ensembl chr10:1,597,761...1,609,000
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Pla2g1b
phospholipase A2 group IB
enables
IDA ISO IEA IBA
(PMID:1420353), (PMID:17603006), (PMID:7060561) (PMID:17603006) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:1420353 PMID:7060561 PMID:17603006 PMID:9487151
GO_REF:0000033 GO_REF:0000107, RGD:2303763
NCBI chr12:46,802,932...46,814,511
Ensembl chr12:41,142,200...41,153,226
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Pla2g2a
phospholipase A2 group IIA
enables
IDA IBA ISO
GO_REF:0000033 (PMID:10358193), (PMID:25082876)
GO_Central RGD
PMID:10358193 PMID:25082876 PMID:9487151
GO_REF:0000033, RGD:2303763
NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014
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Pla2g2c
phospholipase A2, group IIC
enables
IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:8083202
GO_REF:0000033, RGD:69933
NCBI chr 5:156,241,142...156,262,368
Ensembl chr 5:150,959,182...150,981,377
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Pla2g2d
phospholipase A2, group IID
enables
ISO IBA
(PMID:10681567) (PMID:10531313), (PMID:23690440) GO_REF:0000033
RGD GO_Central
PMID:10531313 PMID:10681567 PMID:23690440
GO_REF:0000033
NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:151,018,870...151,022,525
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Pla2g2e
phospholipase A2, group IIE
enables
ISO
(PMID:28883454) (PMID:10531313)
RGD
PMID:10531313 PMID:28883454
NCBI chr 5:151,121,363...151,127,147
Ensembl chr 5:151,121,439...151,126,821
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Pla2g2f
phospholipase A2, group IIF
enables
ISO IBA
(PMID:11112443) GO_REF:0000033
RGD GO_Central
PMID:11112443
GO_REF:0000033
NCBI chr 5:156,270,077...156,276,464
Ensembl chr 5:150,986,788...150,993,175
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Pla2g3
phospholipase A2, group III
enables
ISO
(PMID:12522102), (PMID:18801741), (PMID:28947740) (PMID:23624557)
RGD
PMID:12522102 PMID:18801741 PMID:23624557 PMID:28947740
NCBI chr14:82,589,908...82,597,542
Ensembl chr14:78,368,105...78,373,913
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Pla2g4a
phospholipase A2 group 4A
enables
IDA ISO IBA IEA
(PMID:9403693) GO_REF:0000033 GO_REF:0000107 (PMID:14709560), (PMID:16617059), (PMID:17472963), (PMID:18451993), (PMID:7794891), (PMID:9425121)
RGD GO_Central Ensembl
PMID:7794891 PMID:9403693 PMID:9425121 PMID:14709560 PMID:16617059 PMID:17472963 PMID:18451993 PMID:8148815 More...
GO_REF:0000033 GO_REF:0000107, RGD:1642483
NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
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Pla2g4b
phospholipase A2 group IVB
enables
ISO IBA
(PMID:10358058), (PMID:16617059) GO_REF:0000033 (PMID:10085124)
RGD GO_Central
PMID:10085124 PMID:10358058 PMID:16617059
GO_REF:0000033
NCBI chr 3:127,458,022...127,467,637
Ensembl chr 3:107,005,489...107,013,853
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Pla2g4c
phospholipase A2 group IVC
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:74,236,211...74,274,656
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Pla2g4d
phospholipase A2 group IVD
enables
ISO IBA
(PMID:14709560) GO_REF:0000033
RGD GO_Central
PMID:14709560
GO_REF:0000033
NCBI chr 3:127,674,743...127,695,991
Ensembl chr 3:107,220,978...107,242,224
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Pla2g4e
phospholipase A2, group IVE
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:127,586,318...127,652,369
Ensembl chr 3:107,132,541...107,198,233
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Pla2g4f
phospholipase A2, group IVF
enables
IBA ISO
GO_REF:0000033 (PMID:17293613)
GO_Central RGD
PMID:17293613
GO_REF:0000033
NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:107,250,075...107,264,689
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Pla2g5
phospholipase A2, group V
enables
IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:7947992
GO_REF:0000033, RGD:61698
NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658
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Pla2g15
phospholipase A2, group XV
enables
IDA ISO IBA
(PMID:29724779) GO_REF:0000033 (PMID:11790796), (PMID:16837646), (PMID:17626977)
RGD GO_Central
PMID:11790796 PMID:16837646 PMID:17626977 PMID:29724779 PMID:15294901
GO_REF:0000033, RGD:1304489
NCBI chr19:50,960,568...50,977,948
Ensembl chr19:34,050,694...34,068,063
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Pla2g4a
phospholipase A2 group 4A
enables
ISO IEA
(PMID:12672805) GO_REF:0000107
RGD Ensembl
PMID:12672805
GO_REF:0000107
NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
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Pla2g4c
phospholipase A2 group IVC
enables
ISO
(PMID:10085124)
RGD
PMID:10085124
NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:74,236,211...74,274,656
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Pla2g5
phospholipase A2, group V
enables
ISO IEA
(PMID:23533611) GO_REF:0000107
RGD Ensembl
PMID:23533611
GO_REF:0000107
NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658
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Pla2g6
phospholipase A2 group VI
enables
IDA ISO IEA IBA
PMID:18937505 PMID:24648512 (PMID:15908428), (PMID:20886109), (PMID:23533611) GO_REF:0000002 GO_REF:0000107 GO_REF:0000033 (PMID:17895289), (PMID:18937505)
RGD InterPro Ensembl GO_Central
PMID:15908428 PMID:17895289 PMID:18937505 PMID:20886109 PMID:23533611 PMID:9111008 PMID:18937505 PMID:24648512 More...
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:729507 , RGD:25671384 , RGD:25671395
NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114
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Pla2g7
phospholipase A2 group VII
enables
ISO
(PMID:2040620), (PMID:8624782)
RGD
PMID:2040620 PMID:8624782
NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:17,362,225...17,404,476
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Plb1
phospholipase B1
enables
IDA
PMID:9442065 PMID:9442064
UniProt
PMID:9442065 PMID:9442064
RGD:633237 , RGD:30309923
NCBI chr 6:29,807,127...29,945,607
Ensembl chr 6:24,089,214...24,210,117
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Pnpla8
patatin-like phospholipase domain containing 8
enables
ISS ISO IBA
GO_REF:0000024 (PMID:10744668), (PMID:10833412), (PMID:15695510), (PMID:15908428), (PMID:18171998), (PMID:28442572) GO_REF:0000033 (PMID:28442572)
UniProt RGD GO_Central
PMID:10744668 PMID:10833412 PMID:15695510 PMID:15908428 PMID:18171998 PMID:28442572 More...
GO_REF:0000024 GO_REF:0000033
NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:61,329,810...61,391,734
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Prdx6
peroxiredoxin 6
enables
ISO
(PMID:10893423)
RGD
PMID:10893423
NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
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