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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione peroxidase activity
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Accession:GO:0004602 term browser browse the term
Definition:Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
Synonyms:narrow_synonym: non-selenium glutathione peroxidase activity
 related_synonym: GSH peroxidase activity;   glutathione:hydrogen-peroxide oxidoreductase activity;   reduced glutathione peroxidase activity;   selenium-glutathione peroxidase activity
 alt_id: GO:0016224
 xref: EC:1.11.1.9;   MetaCyc:GLUTATHIONE-PEROXIDASE-RXN;   RHEA:16833;   Reactome:R-HSA-71676 "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O";   reactome:R-HSA-2161791 "15S-HpETE is reduced to 15S-HETE by GPX1/2/4";   reactome:R-HSA-2161946 "5S-HpETE is reduced to 5S-HETE by GPX1/2/4";   reactome:R-HSA-2161959 "12R-HpETE is reduced to 12R-HETE by GPX1/2/4";   reactome:R-HSA-2161999 "12S-HpETE is reduced to 12S-HETE by GPX1/2/4";   reactome:R-HSA-3323013 "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O";   reactome:R-HSA-3341277 "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O";   reactome:R-HSA-3341397 "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O";   reactome:R-HSA-3343700 "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O";   reactome:R-HSA-6799695 "GPX5,6 reduce H2O2 to H2O"


show annotations for term's descendants           Sort by:
glutathione peroxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5ap arachidonate 5-lipoxygenase activating protein enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Clic2 chloride intracellular channel 2 enables ISO (PMID:15147738) RGD PMID:15147738 NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355 		JBrowse link
G Cp ceruloplasmin enables ISS
ISO		 GO_REF:0000024
(PMID:10481051), (PMID:10508415)		 UniProt
RGD		 PMID:10481051 PMID:10508415 GO_REF:0000024 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Gpx1 glutathione peroxidase 1 enables IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:12829378), (PMID:36608588)
GO_REF:0000033
MGI:2158814|MGI:2388705 (MGI:1277786|PMID:9712879), (MGI:1858834|PMID:10754271), (MGI:893248|PMID:9195979), (PMID:10490281), (PMID:10915565), (PMID:10915653), (PMID:11311045), (PMID:11518697), (PMID:11545230), (PMID:11893559), (PMID:12117267), (PMID:12521604), (PMID:12646716), (PMID:12751789), (PMID:15182862), (PMID:15827346), (PMID:9386101), (PMID:9788901)		 Ensembl
RGD
GO_Central		 PMID:9195979 PMID:9386101 PMID:9712879 PMID:9788901 PMID:10490281 More... GO_REF:0000033 GO_REF:0000107 MGI:1277786 MGI:1858834 MGI:893248, RGD:728717 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 enables IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:36608588), (PMID:8428933)
GO_REF:0000033
MGI:1888703 (PMID:11518697), (PMID:12751789)		 Ensembl
RGD
GO_Central		 PMID:8428933 PMID:11518697 PMID:12751789 PMID:36608588 PMID:9685647 GO_REF:0000033 GO_REF:0000107, RGD:1299548 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx3 glutathione peroxidase 3 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:1897960), (PMID:3693360)
GO_REF:0000033
(PMID:10617683)		 UniProt
RGD
GO_Central		 PMID:1897960 PMID:3693360 PMID:10617683 GO_REF:0000024 GO_REF:0000033 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gpx4 glutathione peroxidase 4 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:17630701), (PMID:36608588)
GO_REF:0000033
(PMID:11344099), (PMID:19890015)		 UniProt
RGD
GO_Central		 PMID:11344099 PMID:17630701 PMID:19890015 PMID:36608588 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gpx5 glutathione peroxidase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074 		JBrowse link
G Gpx6 glutathione peroxidase 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:43,408,472...43,416,091
Ensembl chr17:43,408,472...43,416,091 		JBrowse link
G Gpx7 glutathione peroxidase 7 enables IEA GO_REF:0000003
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004 		JBrowse link
G Gpx8 glutathione peroxidase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 enables ISO (PMID:16624487) RGD PMID:16624487 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 enables ISO
IBA		 (PMID:14742434)
GO_REF:0000033
(PMID:12720545)		 RGD
GO_Central		 PMID:12720545 PMID:14742434 GO_REF:0000033 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 enables ISO (PMID:16624487) RGD PMID:16624487 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 enables ISO (PMID:16624487) RGD PMID:16624487 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 enables IDA
ISO		 (PMID:9307035), (PMID:9434735) RGD PMID:9307035 PMID:9434735 PMID:9344408 RGD:2293850 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 IDA RGD PMID:9344408 RGD:2293850 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Ltc4s leukotriene C4 synthase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 enables ISO
IEA		 (PMID:20727966)
GO_REF:0000107		 RGD
Ensembl		 PMID:20727966 GO_REF:0000107 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 enables IDA
ISO
IBA		 (PMID:23409838), (PMID:9278457)
GO_REF:0000033		 RGD
GO_Central		 PMID:9278457 PMID:23409838 PMID:14637132 GO_REF:0000033, RGD:2302289 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 enables IDA
ISO
IBA		 (PMID:9278457)
GO_REF:0000033		 RGD
GO_Central		 PMID:9278457 PMID:14637132 GO_REF:0000033, RGD:2302289 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Mgst3l1 microsomal glutathione S-transferase 3 like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:19,525,509...19,526,128
Ensembl chr14:19,525,558...19,526,016 		JBrowse link
G Prdx6 peroxiredoxin 6 enables IDA
ISO		 (PMID:10893423) RGD PMID:10893423 PMID:8641418 RGD:729495 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Ptges prostaglandin E synthase enables ISO
ISS		 (PMID:12244105)
GO_REF:0000024		 RGD
UniProt		 PMID:12244105 GO_REF:0000024 NCBI chr 3:14,177,892...14,189,236 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20733
    antioxidant activity 94
      peroxidase activity 65
        glutathione peroxidase activity 25
Path 2
Term Annotations click to browse term
  molecular_function 20733
    catalytic activity 6109
      oxidoreductase activity 859
        oxidoreductase activity, acting on peroxide as acceptor 67
          peroxidase activity 65
            glutathione peroxidase activity 25
paths to the root